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Radioprotective effect of endogenous melatonin secretion associated with the circadian rhythm in irradiated rats 

Rakici, Sema Yilmaz; Tumkaya, Levent; Edirvanli, Ozlem Celebi; Yazici, Ufuk; Dursun, Engin; Arpa, Medeni; Mercantepe, Tolga (Taylor & Francis Ltd, 2019)
Purpose: We investigated the radioprotective effect of endogenous melatonin release at different times associated with the circadian rhythm on head and neck radiotherapy. Materials and methods: Two groups of animals were ...

Protective effects of nebivolol on ovarian ischemia-reperfusion injury in rat 

Colak, Sabri; Gurlek, Beril; Topcu, Atilla; Tumkaya, Levent; Mercantepe, Tolga; Yilmaz, Adnan (Wiley, 2020)
Aim Ovarian torsion is a common gynecological emergency of reproductive ages, occurring at rates of 2.7-7.4%. This study aimed to evaluate the antioxidant effects of Nebivolol (NEB) and histopathological changes in ...

Protective Effect of Whortleberry Extract on Salivary Gland Damage Induced by Neck Irradiation in Rats 

Ozgur, Abdulkadir; Terzi, Suat; Ozdemir, Dogukan; Tumkaya, Levent; Rakici, Sema; Mercantepe, Tolga; Dursun, Engin (Sage Publications Inc, 2019)
Radiotherapy is a method of treatment used on malignant head and neck tumors; however, it may lead to adverse effects by influencing other tissues because its effects are not specific to tumor tissues. These adverse effects ...

Prenatal Dönemde 900Mhz Elektromanyetik Alanın Sıçan Omurilik Dokusu Üzerine Etkilerinin Histopatolojik Olarak İncelenmesi 

Mercantepe, Tolga; Tümkaya, Levent; Gökçe, Fatih Mehmet; Uzunok, Barış; Suzan, Zehra Topal; Çınar, Seda; Esmer, Erva (2018)
Amaç: Günümüzde yaşantımıza giren ve giderek artan belli bir frekansta elektromanyetik dalga yayılımına neden olan teknolojik cihazlar insanları elektromanyetik alana maruz bırakmaktadır. Bu cihazlar tarafından yayılan ...

The effects of whortleberry on ischemia reperfusion-induced myocardial injury in rats 

Karakişi, Sedat Ozan; Hemşinli, Doğuş; Ergene, Şaban; Mercantepe, Tolga; Tümkaya, Levent; Yılmaz, Adnan (2020)
Background: The aim of this study was to investigate the potential protective effect of whortleberry by examining the effects on heart tissue at the molecular level of ischemia-reperfusion injury caused by surgical repair ...

Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats 

Köksal, Vaner; Mercantepe, Tolga; Tümkaya, Levent; Oktem, Ibrahim Suat (2020)
AIM: To investigate the role of bipolar electrocautery in the occurrence of epidural fibrosis following lumbar spine laminectomy in a rat model. MATERIAL and METHODS: Fourteen male Sprague–Dawley rats (age: 4–6 months, ...

Effects of Gadodiamide and Gadoteric Acid on Rat Kidneys: A Comparative Study 

Celiker, Fatma Beyazal; Tumkaya, Levent; Mercantepe, Tolga; Beyazal, Mehmet; Turan, Arzu; Beyazal Polat, Hatice; Yilmaz, Adnan (Wiley, 2019)
Background Gadolinium-based contrast agents are complex chelates to provide contrast in NRI. However, recent studies have highlighted the deposition of free Gd+3 ion in various tissues. Purpose To evaluate the histopathological ...

Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury 

Mercantepe, Filiz; Mercantepe, Tolga; Topcu, Atilla; Yilmaz, Adnan; Tumkaya, Levent (Springer, 2018)
Despite the enormous advances made in the field of oncology, no solution to the side effect of nephrotoxicity caused by cisplatin used as an antineoplastic agent for approximately 40 years has yet been discovered. This ...

Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity 

Mercantepe, Tolga; Kalkan, Yildiray; Tumkaya, Levent; Sehitoglu, Ibrahim; Mercantepe, Filiz; Yildirmis, Sermet (Wroclaw Medical Univ, 2018)
Background. Methotrexate (MTX), a folate antagonist, is commonly used in the treatment of many different types of cancer and inflammatory diseases, including pancreatic cancer, although its side effects on the pancreas ...

Effects of 900 MHz electromagnetic field on prenatal locomotor development in rats 

Balik, Mehmet Sabri; Tumkaya, Levent; Sehitoglu, Ibrahim; Kalkan, Yildiray; Yilmaz, Adnan; Balik, Gulsah; Mercantepe, Tolga (E-Century Publishing Corp, 2019)
Introduction: the present study investigated the effects of 900 MHz electromagnetic field (EMF) on locomotor system development in pregnant rats. Materials and methods: Following impregnation, the rats were divided into a ...
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