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Toplam kayıt 19, listelenen: 1-10
Vanillic acid abrogates cisplatin-induced ovotoxicity through activating Nrf2 pathway
(Elsevier, 2023)
Although cisplatin (CDDP) is an effective anticancer agent, the ovotoxicity that can occur in female patients limits its use. Oxidative stress (OS) and inflammation are known to contribute to CDDP-induced ovotoxicity. ...
Arbutin abrogates testicular ischemia/reperfusion injury in rats through repression of inflammation and ER stress
(Elsevier, 2023)
The aim of this study was to investigate the effects of arbutin (ARB) administration on oxidative stress, inflammation, endoplasmic reticulum (ER) stress and apoptosis in an experimental testicular torsion/detorsion ...
The effects of dexmedetomidine on early acute kidney injury in severely burned rats
(Verduci Publisher, 2023)
OBJECTIVE: Burns are a global
medical and economic problem. In addition to
high costs, the lengthy therapeutic process and
the emotional trauma experienced by patients
and their families indirectly worsen the socioeconomic ...
Radioprotective effects of dexmedetomidine on X-ray-induced testicular damage
(Verduci Publisher, 2023)
OBJECTIVE: Approximately 70%
of cancer patients require radiotherapy. However, despite its effectiveness in the treatment of
cancer, radiotherapy can also affect and damage
surrounding healthy tissues in addition to ...
Neuroprotective effects of Vaccinium myrtillus on damage-related brain injury
(2023)
Traumatic brain injury may trigger the secondary brain injury, which has the potential to be reversible and thus
preventable. Anthocyanins are phylotherapeutic plants, which are reported to exhibit anti-inflammatory ...
Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats
(Taylor & Francis Ltd., 2023)
The aim of this study was to determine the possible therapeutic effect of chlorogenic acid (CGA) on cisplatin (CDDP)-induced ovarian damage in rats. Rats were first exposed to CDDP (5 mg/kg) and then treated CGA (1.5 and ...
Dexmedetomidine alleviates vacuolization and necrosis in tubular epithelial cells induced by aortic cross-clamping
(Verduci Publisher, 2023)
OBJECTIVE: Acute kidney inju-ry (AKI) is one of the main causes of mortality in patients undergoing emergency surgery due to an abdominal aortic aneurysm. This study aimed to determine the potential nephroprotec-tive ...
Ethyl pyruvate attenuates cisplatin-induced ovarian injury in rats via activating Nrf2 pathway
(Taylor & Francis Ltd., 2023)
Although cisplatin (CDDP) is an antineoplastic drug widely used for the treatment of various tumors, its toxicity on the reproductive system is a concern for patients. Ethyl pyruvate (EP) possesses potent antioxidant and ...
The therapeutic effect of silibinin against 5-fluorouracil-induced ovarian toxicity in rats
(Wiley, 2023)
5-Fluorouracil (5-FU) is a fluoropyrimidine group antineoplastic drug with antimetabolite properties and ovotoxicity is one of the most important side effects. Silibinin (SLB) is a natural compound that is used worldwide ...
Agomelatine on cisplatin-induced nephrotoxicity via oxidative stress and apoptosis
(Springer, 2023)
Drug-induced nephrotoxicity is the greatest deterrent to the use of cisplatin, which is a frequently used chemotherapeutic with
proven efectiveness in cancer therapy. Agomelatine, which is used in the treatment of sleep ...