Kurum Yazarı "Ülker, Serdar" Fakülteler İçin Listeleme
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Structure-based hybridization, conventional and microwave irradiated synthesis, biological evaluation and molecular docking studies of new compounds derived from thiomorpholin
Demirci, Serpil; Aksakal, Fatma; Çolak, Nesrin; Ülker, Serdar; Demirbaş, Ahmet; Demirbaş, Neslihan (Bentham Science Publ Ltd, 2017)Background: the amine 2 obtained via two steps starting from thiomorpholine was converted into the corresponding 1,3-thiazole (4), arylmethileneamino (5a- d) and hydrazide (7) derivatives using conventional and also microwave ... -
Syntheses and biological activities of new hybrid molecules containing different heterocyclic moieties
Ceylan, Şule; Bektaş, Hakan; Bayrak, Hacer; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay; Ülker, Serdar (Wiley, 2013)4-Aryl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-(thi)oles 5-7, obtained starting from nicotinic acid hydrazide were converted to the corresponding Mannich bases 12-24 by the reaction with several heterocyclic amines in the ... -
Synthesis and evaluation of alpha-glucosidase and pancreatic lipase inhibition by quinazolinone-coumarin hybrids
Menteşe, Emre; Karaali, Nesrin; Akyüz, Gülay; Yılmaz, Fatih; Ülker, Serdar; Kahveci, Bahittin (Springer, 2016)A new series of 2-substituted quinazolin-4(3H)-one derivatives including coumarin nucleus has been synthesized and screened for their lipase and a-glucosidase inhibition properties. Among the synthesized compounds, ... -
Synthesis and pharmacological activities of some new 2-[1-Heptyl-3-(4-methoxybenzyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl] acetohydrazide derivatives
Bekircan, Olcay; Menteşe, Emre; Ülker, Serdar (Walter de Gruyter Gmbh, 2014)In the present investigation, the key intermediate acetohydrazide derivative 5 was synthesized starting from 3-(4-methoxybenzyl)-4-amino-4,5-dihydro-1,2,4-triazol-5-one (1) by a four-step reaction. Thiosemicarbazides 6a-f ... -
Synthesis and study of alpha-glucosidase inhibitory, antimicrobial and antioxidant activities of some benzimidazole derivatives containing triazole, thiadiazole, oxadiazole, and morpholine rings
Menteşe, Emre; Ülker, Serdar; Kahveci, Bahittin (Springer, 2015)A new series of 2-(4-bromobenzyl)- and 2-(4-fluorobenzyl)-1H-benzimidazole derivatives containing 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole, and morpholine rings has been synthesized. the structures of the newly ... -
Synthesis of some heterofunctionalized penicillanic acid derivatives and investigation of their biological activities
Demirci, Serpil; Demirbaş, Ahmet; Ülker, Serdar; Alpay-Karaoğlu, Şengül; Demirbaş, Neslihan (Wiley-V C H Verlag Gmbh, 2014)6-Substituted amino-penicillanic acid esters were synthesized starting with 6-apa. the compounds containing a 1,3-thiazole- or 1,3-thiazolidinone nucleus linked to the penicillanic acid skeleton via a hydrazino linkage ... -
Synthesis of some new 1,2,4-triazole derivatives starting from 3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol with anti-lipase and anti-urease activities
Bekircan, Olcay; Menteşe, Emre; Ülker, Serdar; Küçük, Çağatay (Wiley-V C H Verlag Gmbh, 2014)In the present study, starting compound 4 was prepared by deamination of compound 2 in the presence of hypophosphorous acid and sodium nitrite. Treatment of compound 4 with ethyl bromoacetate produced ethyl[3-(4-chloroph ... -
Synthesis of some new hybride molecules containing several azole moieties and investigation of their biological activities
Ceylan, Şule; Bayrak, Hacer; Demirbaş, Ahmet; Ülker, Serdar; Alpay-Karaoğlu, Şengül; Demirbaş, Neslihan (Maik Nauka/Interperiodica/Springer, 2014)1,2,4-Triazole-3-one prepared from tryptamine was converted to the corresponding carbothioamides by several steps. Their treatment with ethyl bromoacetate or 4-chlorophenacyl bromide produced the corresponding 5-oxo-1,3- ... -
Synthesis of some novel heterocylic compounds derived from 2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetohydrazide and investigation of their lipase and alpha-glucosidase inhibition
Bekircan, Olcay; Ülker, Serdar; Menteşe, Emre (Taylor & Francis Ltd, 2015)In the present study, 2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetohydrazide (1) was used as starting compound for the synthesis of 2-{[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl ... -
Synthesis, molecular docking and biological evaluation of some benzimidazole derivatives as potent pancreatic lipase inhibitors
Menteşe, Emre; Yılmaz, Fatih; Emirik, Mustafa; Ülker, Serdar; Kahveci, Bahittin (Academic Press Inc Elsevier Science, 2018)In this study, a new series of benzimidazole and bisbenzimidazole derivatives were prepared via the reaction of iminoester hydrochlorides and o-phenylenediamines and then screened for their lipase inhibition properties. ...