Kurum Yazarı "Yalçın Özkat, Gözde" Fakülteler İçin Listeleme
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Computational studies with flavonoids and terpenoids as BRPF1 inhibitors: in silico biological activity prediction, molecular docking, molecular dynamics simulations, MM/PBSA calculations
Yalçın Özkat, Gözde (Taylor & Francis Ltd., 2022)The BRPF1 protein is encoded by the BRPF1 gene. In addition, the BRPF1 gene is known to be upregulated in leukaemia. Recent studies have shown that it is also overexpressed in hepatocellular carcinoma (HCC) as well. ... -
Design, synthesis and biological evaluation of novel bischalcone derivatives as potential anticancer agents
Burmaoğlu, Serdar; Göbek, Arzu; Aydın, Büşra Öztürk; Yurtoğlu, Emine; Aydın, Büşra Nur; Yalçın Özkat, Gözde; Hepokur, Ceylan; Şimşek Özek, Nihal; Ayşin, Ferhunde; Altuntaş, Ramazan; Algül, Öztekin (Elsevier, 2021)Building on our previous work that discovered chalcone as a promising pharmacophore for anticancer activity, we have various other chalcone derivatives and have synthesized a series of novel bischalcone to explore their ... -
Design, synthesis, and computational studies of benzimidazole derivatives as new antitubercular agents
Yalçın Özkat, Gözde; Ersan, Ronak H.; Ülger, Mahmut; Ülger, Seda T.; Burmaoğlu, Serdar; Yıldız, İlkay; Algül, Öztekin (Taylor & Francis Ltd., 2022)The increase in the drug-resistant strains of Mycobacterium tuberculosis has led researchers to new drug targets. The development of new compounds that have effective inhibitory properties with the selective vital structure ... -
Determination of novel SARS-CoV-2 inhibitors by combination of machine learning and molecular modeling methods
Güner, Ersin; Özkan, Özgür; Yalçın Özkat, Gözde; Ölgen, Süreyya (Bentham Science, 2023)Introduction: Within the scope of the project, this study aimed to find novel inhibitors by combining computational methods. In order to design inhibitors, it was aimed to produce molecules similar to the RdRp inhibitor ... -
Development of new cyclophilin d receptor inhibitors for the treatment of multiple sclerosis
Yalçın Özkat, Gözde; Huylu, Birsen (Ankara University, 2022)Objective: In this study, it was aimed to carry out computational studies for the development of new molecules for the inhibition of the cyclophilin D (CypD) receptor, which causes the disability of mitochondrial function ... -
Discovery of 5-(or 6)-benzoxazoles and oxazolo[4,5-b]pyridines as novel candidate antitumor agents targeting hTopo II alpha
Karataş, Esin; Foto, Egemen; Ertan Bolelli, Tuğba; Yalçın Özkat, Gözde; Yılmaz, Serap; Ataei, Şanaz; Zilifdar, Fatma; Yıldız, İlkay (Elsevier, 2021)Discovery of novel anticancer drugs which have low toxicity and high activity is very significant area in anticancer drug research and development. One of the important targets for cancer treatment research is topoisomerase ... -
Drug repositioning approach for the treatment of ankylosing spondylitıs
Yalçın Özkat, Gözde (Ankara University, 2022)Objective: In this study, it was aimed to determine an FDA-approved molecule that inhibits the IL-17 receptor, which is an important target for the prevention of inflammation in Ankylosing Spondylitis (AS), using the ... -
In silico studies to develop new GSK3 beta inhibitors effective in the 's disease
Yalçın Özkat, Gözde; Yıldız, İlkay (Bentham Science Publications, 2022)Background: Alzheimer's disease affects a large part of the world's population by prolonging the human life span and becoming an economic burden in the health system. Therefore, its treatment becomes more and more important ... -
In silico studies to develop new GSK3β inhibitors effective in the alzheimer's disease
Yalçın Özkat, Gözde; Yıldız, İlkay (Bentham Science Publishers, 2022)Background: Alzheimer's disease affects a large part of the world’s population by prolonging the human life span and becoming an economic burden in the health system. Therefore, its treatment be-comes more and more important ... -
Molecular modeling strategies of cancer multidrug resistance
Yalçın Özkat, Gözde (Elsevier, 2021)Cancer remains a leading cause of morbidity and mortality worldwide. Hence, the increase in cancer cases observed in the elderly population, as well as in children and adolescents, makes human malignancies a prime target ... -
MS hastalığının tedavisine yönelik yeni Sfingosin-1-Fosfat reseptör modülatörlerinin geliştirilmesi
Huylu, Birsen; Yalçın Özkat, Gözde (Konya Teknik Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, 2022)Hesaplamalı ilaç tasarımı; ilaç geliştirme prosesini hızlandırmakla birlikte maliyeti de düşürerek tıp mühendisliğinin önde gelen alanlarından birine dönüşmüştür. MS hastalığı ölümle sonuçlanmasının yanı sıra, hastalarda ... -
Synthesis and molecular docking studies of some novel antimicrobial benzamides
Acar, Cemre; Yalçın Özkat, Gözde; Ertan-Bolelli, Tuğba; Onurdağ, Fatma Kaynak; Ökten, Suzan; Şener, Funda; Yıldız, İlkay (Academic Press Inc Elsevier Science, 2020)Common use of classical antibiotics has caused to the growing emergence of many resistant strains of pathogenic bacteria. Therefore, we aimed to synthesize a number of N-(2-hydroxy-(4 or 5)-nitrophenyl)benzamide derivatives ... -
Synthesis, biological activities, antioxidant properties, and molecular docking studies of novel bis-schiff base podands as responsive chemosensors for anions
Yapar, Gönül; Demir, Neslihan; Kiraz, Aşkın; Yalçın Özkat, Gözde; Yıldız, Mustafa (Elsevier, 2022)In this study, bis-carbonyl podand (triethylene glycol bis(2-carbonylphenyl)ether) ( 1 ) was synthesized from the reaction of triethylene glycol dichloride with salicylaldehyde. Then, Schiff base podans ( 2 and 3 ) were ... -
Synthesis, molecular docking and some metabolic enzyme inhibition properties of biphenyl-substituted chalcone derivatives
Burmaoğlu, Serdar; Kazancıoğlu, Elif Akın; Kazancıoğlu, Mustafa Z.; Sağlamtaş, Rüya; Yalçın Özkat, Gözde; Gülçin, İlhami; Algül, Öztekin (Elsevier, 2022)The new synthesized biphenyl-substituted chalcone derivatives were evaluated against the human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. ...