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dc.contributor.authorYaşar, A.
dc.contributor.authorAkapinar, K.
dc.contributor.authorBurnaz, N.A.
dc.contributor.authorKüçük, M.
dc.contributor.authorKaraoğlu, S.A.
dc.contributor.authorDoğan, N.
dc.contributor.authorYayh, N.
dc.date.accessioned2020-12-19T20:12:34Z
dc.date.available2020-12-19T20:12:34Z
dc.date.issued2008
dc.identifier.issn1612-1872
dc.identifier.urihttps://doi.org/10.1002/cbdv.200890078
dc.identifier.urihttps://hdl.handle.net/11436/3900
dc.descriptionPubMed: 18493968en_US
dc.description.abstract4?-Azaflavone (=2-(pyridin-4-yl)-4H-1-benzopyran-4-one; 4) and 3-[(pyridin-4-yl)methyl]-4?-azaflavone (5) were synthesized by a simple environmentally friendly microwave-assisted one-pot method through the cyclization of 3-hydroxy-1-(2-hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one (1), (E)-2?-hydroxy-4-azachalcone (2; chalcone=1,3-diphenylprop-2-en-1-one), and 2?-hydroxy-2-[(hydroxy)(pyridin-4-yl)methyl]-4?-azachalcone (3) under solventless conditions using silica-supported NaHSO4, followed by treatment with base. In addition, N-alkyl-substituted 4?-azaflavonium bromides 6 and 7 were prepared from compounds 4 and 5, respectively. The antimicrobial and antioxidant activities of compounds 1-7 were tested. The N-alkyl-substituted 4?-azaflavonium bromides 6 and 7 showed high antimicrobial activity against the Gram-positive bacteria and the fungus tested, with MIC values close to those of reference antimicrobials ampicilline and fluconazole. The alkylated compounds 6 and 7 also showed a good antioxidant character in the two antioxidant methods, DPPH (=1,1-diphenyl-2-picrylhydrazyl) radical-scavenging and ferric reducing/ antioxidant power (FRAP) tests. © 2008 Verlag Helvetica Chimica Acta AG, Zürich.en_US
dc.language.isoengen_US
dc.publisher0-Belirleneceken_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleMicrowave-assisted synthesis of 4?-azaflavones and their n-alkyl derivatives with biological activitiesen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜen_US
dc.identifier.doi10.1002/cbdv.200890078
dc.identifier.volume5en_US
dc.identifier.issue5en_US
dc.identifier.startpage830en_US
dc.identifier.endpage838en_US
dc.relation.journalChemistry and Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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