dc.contributor.author | Yaşar, A. | |
dc.contributor.author | Akapinar, K. | |
dc.contributor.author | Burnaz, N.A. | |
dc.contributor.author | Küçük, M. | |
dc.contributor.author | Karaoğlu, S.A. | |
dc.contributor.author | Doğan, N. | |
dc.contributor.author | Yayh, N. | |
dc.date.accessioned | 2020-12-19T20:12:34Z | |
dc.date.available | 2020-12-19T20:12:34Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 1612-1872 | |
dc.identifier.uri | https://doi.org/10.1002/cbdv.200890078 | |
dc.identifier.uri | https://hdl.handle.net/11436/3900 | |
dc.description | PubMed: 18493968 | en_US |
dc.description.abstract | 4?-Azaflavone (=2-(pyridin-4-yl)-4H-1-benzopyran-4-one; 4) and 3-[(pyridin-4-yl)methyl]-4?-azaflavone (5) were synthesized by a simple environmentally friendly microwave-assisted one-pot method through the cyclization of 3-hydroxy-1-(2-hydroxyphenyl)-3-(pyridin-4-yl)propan-1-one (1), (E)-2?-hydroxy-4-azachalcone (2; chalcone=1,3-diphenylprop-2-en-1-one), and 2?-hydroxy-2-[(hydroxy)(pyridin-4-yl)methyl]-4?-azachalcone (3) under solventless conditions using silica-supported NaHSO4, followed by treatment with base. In addition, N-alkyl-substituted 4?-azaflavonium bromides 6 and 7 were prepared from compounds 4 and 5, respectively. The antimicrobial and antioxidant activities of compounds 1-7 were tested. The N-alkyl-substituted 4?-azaflavonium bromides 6 and 7 showed high antimicrobial activity against the Gram-positive bacteria and the fungus tested, with MIC values close to those of reference antimicrobials ampicilline and fluconazole. The alkylated compounds 6 and 7 also showed a good antioxidant character in the two antioxidant methods, DPPH (=1,1-diphenyl-2-picrylhydrazyl) radical-scavenging and ferric reducing/ antioxidant power (FRAP) tests. © 2008 Verlag Helvetica Chimica Acta AG, Zürich. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | 0-Belirlenecek | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.title | Microwave-assisted synthesis of 4?-azaflavones and their n-alkyl derivatives with biological activities | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ | en_US |
dc.identifier.doi | 10.1002/cbdv.200890078 | |
dc.identifier.volume | 5 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 830 | en_US |
dc.identifier.endpage | 838 | en_US |
dc.relation.journal | Chemistry and Biodiversity | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |