dc.contributor.author | Yolal, Meltem | |
dc.contributor.author | Başoğlu, Serap | |
dc.contributor.author | Bektaş, Hakan | |
dc.contributor.author | Demirci, Serpil | |
dc.contributor.author | Karaoğlu, Şengül Alpay | |
dc.contributor.author | Demirbaş, Ahmet | |
dc.date.accessioned | 2020-12-19T20:16:27Z | |
dc.date.available | 2020-12-19T20:16:27Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Yolal, M., Başoğlu, S., Bektaş, H., Demirci, S., Karaoğlu, Ş.A. & Demirbaş, A. (2012). Synthesis of eperezolid-like molecules and evaluation of their antimicrobial activities. Russian Journal of Bioorganic Chemistry, 38(5), 539-549. https://doi.org/10.1134/S106816201205010X | en_US |
dc.identifier.issn | 1068-1620 | |
dc.identifier.uri | https://doi.org/10.1134/S106816201205010X | |
dc.identifier.uri | https://hdl.handle.net/11436/4199 | |
dc.description.abstract | 3-Fluoro-4-(4-phenylpiperazin-l-yl)aniline (II) prepared from 3,4-difluoro nitrobenzene was converted to the corresponding Schiff bases (III) and (IV) by treatment with 4-methoxybenzaldehyde and indol-3-carbaldehyde, respectively. Treatment of amine (II) with 4-fluorophenyl isothiocyanate afforded the corresponding thiourea derivative (V). Compound (V) was converted to thiazolidinone and thiazoline derivatives (VI) and (VII) by cyclocondensation with ethylbromoacetate or 4-chlorophenacylbromide, respectively. The synthesis of carbothioamide derivative (X) was performed starting from compound (II) by three steps. Treatment of compound (X) with sodium hydroxide, sulfuric acid, or chlorophenacyl bromide generated the corresponding 1,2,4-triazole (XI), 1,3,4-thiadiazole (XII), and 1,3-thiazolidinone (XIII) derivatives, respectively. The structural assignments of new compounds were based on their elemental analysis and spectral (IR, 1H-NMR, 13C-NMR, and LC-MS) data. In the antimicrobial activity study all the compounds revealed high anti-Mycobacterium smegmatis activity. © Pleiades Publishing, Ltd., 2012. | en_US |
dc.description.sponsorship | Karadeniz Teknik Üniversitesi: 2007.111.002.6 | en_US |
dc.description.sponsorship | The work was supported by Karadeniz Technical University, BAP, Turkey (Ref. No. 2007.111.002.6). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer Link | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | 1,2,4-triazole | en_US |
dc.subject | 1,3,4-thiadiazole | en_US |
dc.subject | 1,3-thiazolidinone | en_US |
dc.subject | Antimicrobial activity | en_US |
dc.subject | Piperazin | en_US |
dc.title | Synthesis of eperezolid-like molecules and evaluation of their antimicrobial activities | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Biyoloji Bölümü | en_US |
dc.contributor.institutionauthor | Karaoğlu, Şengül Alpay | |
dc.identifier.doi | 10.1134/S106816201205010X | |
dc.identifier.volume | 38 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 539 | en_US |
dc.identifier.endpage | 549 | en_US |
dc.relation.journal | Russian Journal of Bioorganic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |