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Chemoradiotherapy for elderly patients with rectal cancer: A single‑institution study

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Erişim

info:eu-repo/semantics/openAccess

Tarih

2022

Yazar

Uslu, Gonca H.
Rakıcı, Sema Yılmaz

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Künye

Uslu, G. H., & Rakici, S. Y. (2022). Chemoradiotherapy for elderly patients with rectal cancer: A single-institution study. Journal of cancer research and therapeutics, 18(Supplement), S397–S404. https://doi.org/10.4103/jcrt.jcrt_1967_22

Özet

Introduction: The incidence of cancer, particularly rectal cancer (RC), in older adults is gradually increasing. The aim of the present study was to evaluate radiotherapy (RT) and chemoradiotherapy (CRT) results, clinicopathological features, and survival factors in older patients with RC. Methods: We evaluated patients aged ≥65 years with RC treated at a radiation oncology clinic. The demographic, clinical, and histopathological data of the patients were obtained by reviewing their medical records. The toxicity criteria of the Radiation Therapy Oncology Group were applied. Results: Among 401 patients with RC, 183 (45.6%) were older adults (65–92 years). Furthermore, 122 (66.7%) patients had clinically stage 3 and above RC, and 183 and 91 patients received RT and neoadjuvant CRT, respectively. Surgical treatment was performed for 116 (63.4%) patients, 41 (34.4%) and 76 (65.6%) of whom underwent postoperative CRT and preoperative RT, respectively. Grade 3 or higher toxicity was observed in 22 (18.9%) patients during CRT. RT was performed in 64 patients(35%) at a 1–15‑day interval. The mean follow‑up duration was 34.7 (range, 1.4–149.0) months. The 2‑ and 5‑year overall survival (OS) rates were 71.4 and 37.4%, respectively, and the 2‑ and 5‑year disease‑free survival (DFS) rates were 65.7 and 35.3%, respectively. OS was 49.4 and 34.9 months for patients aged 65–74 and ≥75 years, respectively. Survival was shorter in patients with the advanced geriatric disease (p = 0.013). In the multivariate analysis, factors affecting overall and DFS were age, distance from the tumor to the anal canal, and metastasis (p < 0.05). Conclusion: The results of this study suggested that the selection of treatment modalities for older patients with RC should be based on performance status and not age. RT and CRT were safe treatment modalities for older patients with RC, particularly for those who could not undergo surgery

Kaynak

Journal of Cancer Research and Therapeutics

Sayı

18

Bağlantı

https://doi.org/10.4103/jcrt.jcrt_1967_22
https://hdl.handle.net/11436/7930

Koleksiyonlar

  • PubMed İndeksli Yayınlar Koleksiyonu [2443]
  • TF, Dahili Tıp Bilimleri Bölümü Koleksiyonu [1571]



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