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Synthesis and study of antitumor activity of some new 2-(4-methoxybenzyl)-1h-benzimidazole derivatives bearing triazole, oxadiazole and ethanol moiety
(Editura Acad Romane, 2016)
A series of novel 1,2-disubstituted benzimidazole derivatives containing hydrazinecarbothioamide (7a-c), 1,2,4-triazole (8a-c) and 1,3,4-oxadiazole (5) moiety were synthesized starting from 2-(4-methoxybenzyl)-1H-benzimidazole. ...
Determination of biological activities and pka at drug active substance in some bisbenzimidazoles derivatives
(Raman Publ, 2016)
Bisbenzimidazole derivatives have known different structures as drug active substance were evaluated for their biological activities such as antiviral and anti-tumor activities. in addition, acid dissociation constants ...
Experimental and theoretical studies of 4-[(4-methyl-5-phenyl-4h1,2,4-tiıazol-3-yl)sulfanyl]benzene-1,2-dicarbonitrile
(Soc Chemists Technologists Madeconia, 2016)
In this study, 4-[(4-methy1-5-pheny1-4H-1,2,4-triazol-3-yl)sulfanyl]benzene-1,2-dicarbonitrile was synthesized and its molecular structure was characterized by means of FT-IR. and X-ray diffraction methods. the crystal is ...
Ferrocenyl-substituted dinuclear Cu(II) complex: Synthesis, spectroscopy, electrochemistry, DFT calculations and catecholase activity
(Elsevier Science Bv, 2016)
A new ferrocenyl-substituted heterocyclic hydrazide ligand and its Cu(II) complex were prepared. the DFT calculations were performed to determine the electronic and molecular structures of the title compounds. the electronic ...
Metallo-phthalocyanines containing triazole substituents: Synthesis, spectroscopic and photophysicochemical properties
(Taylor & Francis Ltd., 2022)
Magnesium(II) (4), lead(II) (5) and zinc(II) (6) phthalocyanines were prepared. The structures of 4-6 were confirmed by the spectroscopic characterization such as FT-IR, H-1-NMR, MALDI-TOF mass, UV-vis and fluorescence ...
Novel coumarin derivatives containing a triazole moiety: A study on synthesis, cytotoxicity, membrane dysfunction, apoptosis, cell cycle, and antiangiogenic effects
(Bentham Science Publications, 2022)
Background: Coumarin is a functional compound with a pronounced wide range of biological activities and has recently been shown to have anticancer effects on various human cancer cells. Cisplatin is widely used in treating ...
Synthesis and biological evaluation of benzimidazolone bridged triheterocyclic compounds
(Wiley, 2021)
A new series of benzimidazolone bridged triheterocyclic compounds bearing thiosemicarbazide, thiadiazole, triazole, moieties was synthesized and then screened for their in vitro urease, alpha-glucosidase, and acetylcholinesterase ...
Synthesis and anticancer activities of some new coumarin derivatives including the triazole ring and their in silico molecular docking studies
(Wiley-V C H Verlag Gmbh, 2020)
The synthesis, docking study, and investigation of the anticancer activities of some coumarin derivatives containing the triazole ring are reported in this study. the newly synthesized compounds were screened for their in ...
Novel peripheral and non-peripheral oxobenzo[d]thiazol substituted cobalt phthalocyanines: Synthesis, electrochemistry, spectroelectrochemistry, electrocatalytic hydrogen production in alkaline medium
(Elsevier, 2022)
In this study novel oxobenzo[d]thiazol substituted cobalt phthalocyanine complexes were synthesized and characterized by FT-IR, NMR, UV-vis spectroscopy, and mass spectrometry. The redox properties of peripheral and ...
Design and synthesis of benzimidazole derivatives as apoptosis-inducing agents by targeting Bcl-2 protein
(Springer, 2022)
Bcl-2, an anti-apoptotic protein, is a well-known and appealing cancer therapy target. Novel series of benzimidazole derivatives were synthesized and tested for their activity as Bcl-2 inhibitors on T98G glioblastoma, PC3 ...