Yazar "RTEÜ, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü" için PubMed İndeksli Yayınlar Koleksiyonu listeleme
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Alpha-pinene neutralizes cisplatin-induced reproductive toxicity in male rats through activation of Nrf2 pathway
Demir, Selim; Menteşe, Ahmet; Türkmen Usta, Zeynep; Türkmen Alemdar, Nihal; Ayazoğlu Demir, Elif; Aliyazıcıoğlu, Yüksel (Springer, 2023)Purpose Testicular toxicity is one of the most important side efects of cisplatin (CP) therapy. Alpha-pinene (AP) is a naturally occurring monoterpene with antioxidant character in plants. Here, we aimed to evaluate the ... -
Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Livaoğlu, Ayten; Türkmen Alemdar, Nihal; Demir, Selim (Taylor & Francis Ltd., 2021)The aim of the present study was to evaluate the protective effect of gallic acid (GA) against cisplatin (CDDP)-induced ovarian toxicity, for the first time. The ovarian damage was generated with CDDP (5 mg/kg) intraperitoneally ... -
The ameliorative effect of Primula vulgaris on cisplatin-induced nephrotoxicity in rats and quantification of its phenolic components using LC-ESI-MS/MS
Turan, İbrahim; Canbolat, Deniz; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Türkmen Alemdar, Nihal; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Cisplatin (CDDP) is an important chemotherapeutic agent, accumulation of which in kidney tissue causes nephrotoxicity and renal failure. The aim of this study was to evaluate, for the first time in the literature, the ... -
Arbutin abrogates testicular ischemia/reperfusion injury in rats through repression of inflammation and ER stress
Demir, Elif Ayazoğlu; Demir, Selim; Kazaz, İlke Onur; Küçük, Hatice; Alemdar, Nihal Türkmen; Büyük, Ali; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)The aim of this study was to investigate the effects of arbutin (ARB) administration on oxidative stress, inflammation, endoplasmic reticulum (ER) stress and apoptosis in an experimental testicular torsion/detorsion ... -
Bread consumption-induced heavy metal exposures and health risk assessment of pregnant women: Turkey
Köse, Burcu Genç; Pekmezci, Hilal; Başaran, Burhan (Springer, 2023)Affordable, nutritious, and easily available bread has a significant place in the nutrition of pregnant women. This study aims to determine bread consumption-induced heavy metal exposure in pregnant women with different ... -
Chlorogenic acid ameliorates torsion/detorsion-induced testicular injury via decreasing endoplasmic reticulum stress
Kazaz, İlke Onur; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Türkmen Alemdar, Nihal; Doğan, Sedanur Yılmaz; Bostan, Serdar; Menteşe, Ahmet (Elsevier, 2022)Backround Testicular torsion (TT) is an urological emergency situation especially in adolescents and young men. The main pathophysiology of testicular torsion/detorsion (T/D) is ischemia-reperfusion (I/R) injury. I/R ... -
Chlorogenic acid attenuates cisplatin-induced ovarian injury in rats
Demir, Elif Ayazoğlu; Menteşe, Ahmet; Livaoğlu, Ayten; Alemdar, Nihal Türkmen; Aliyazıcıoğlu, Yüksel; Demir, Selim (Taylor & Francis Ltd., 2023)The aim of this study was to determine the possible therapeutic effect of chlorogenic acid (CGA) on cisplatin (CDDP)-induced ovarian damage in rats. Rats were first exposed to CDDP (5 mg/kg) and then treated CGA (1.5 and ... -
Comparison of preoperative and postoperative sexual dysfunction in male patients with lumbar disc herniation
Uzun Şahin, Ceyda; Aydın, Merve; Kalkışım, Selçuk; Şahin, Handan; Civil Arslan, Filiz (Turkish Neurosurgical Society, 2022)AIM: To compare preoperative and postoperative sexual dysfunction in male patients diagnosed with lumbar disc herniation (LDH). MATERIAL and METHODS: This study was conducted in a single group with a pretest???posttest ... -
COVID-19 vaccine acceptance, trust in vaccine, anxiety levels, and related factors in Turkish society
Aydın, Merve; Kulakaç, Nurşen; Uzun Şahin, Ceyda (Cambridge University Press, 2023)Background: Vaccine acceptance and trust in vaccines pose a complex process affected by many factors. The present study was conducted to determine coronavirus disease 2019 (COVID-19) vaccine acceptance, trust in vaccines, ... -
Effect of chrysin on endoplasmic reticulum stress in a rat model of testicular torsion
Kazaz, İlke Onur; Demir, Selim; Kerimoğlu, Gökçen; Çolak, Fatih; Alemdar, Nihal Türkmen; Akman, Ahmet Uğur; Çeküç, Ozan Can; Menteşe, Ahmet (Taylor & Francis Ltd., 2021)Background The purpose of this study was to evaluate the possible therapeutic effect of chrysin (CHS) on testicular torsion/detorsion (T/D) injury in vivo through the mechanisms of oxidative stress and endoplasmic reticulum ... -
Ethyl pyruvate attenuates cisplatin-induced ovarian injury in rats via activating Nrf2 pathway
Demir, Selim; Menteşe, Ahmet; Küçük, Hatice; Yuluğ, Esin; Alemdar, Nihal Türkmen; Demir, Elif Ayazoğlu; Aliyazıcıoğlu, Yüksel (Taylor & Francis Ltd., 2023)Although cisplatin (CDDP) is an antineoplastic drug widely used for the treatment of various tumors, its toxicity on the reproductive system is a concern for patients. Ethyl pyruvate (EP) possesses potent antioxidant and ... -
Evaluation of the therapeutic effects of arbutin on cisplatin-induced ovarian toxicity in rats through endoplasmic reticulum stress and Nrf2 pathway
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Yılmaz, Zeynep Sağnak; Türkmen Alemdar, Nihal; Demir, Selim; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Arbutin (ARB) is a glycosylated hydroquinone with potent antioxidant effects. Although cisplatin (CP) is widely used in chemotherapy, its toxicity in healthy tissues, including ovotoxicity, is an insurmountable problem. ... -
Experiences and psychosocial difficulties of frontline health care workers struggling with Covid-19 in Turkey: A qualitative study
Uzun Şahin, Ceyda; Aydın, Merve; Usta, Abdullah; Sakin, Mustafa (İstanbul University, 2022)AIM: This study was performed to explore the experiences and the psychosocial difficulties faced by nurses and physicians involved in the treatment and care for COVID-19 adult patients in the intensive care unit. METHOD: ... -
Experimental models to study immune dysfunction in the pathogenesis of Parkinson’s disease
Saponjic, Jasna; Mejías, Rebeca; Nikolovski, Neda; Dragic, Milorad; Çanak, Asuman; Papoutsopoulou, Stamatia; Gürsoy-Özdemir, Yasemin; Fladmark, Kari E.; Ntavaroukas, Panagiotis; Bayar Muluk, Nuray; Zeljkovic Jovanovic, Milica; Fontán-Lozano, Ángela; Comi, Cristoforo; Marino, Franca (MDPI, 2024)Parkinson’s disease (PD) is a chronic, age-related, progressive multisystem disease associated with neuroinflammation and immune dysfunction. This review discusses the methodological approaches used to study the changes ... -
Exploring anxiety levels in healthcare workers during COVID-19 pandemic: Turkey sample
Şahin, Ceyda Uzun; Kulakaç, Nursen (Springer, 2021)As in the whole world, the Novel Coronavirus (COVID-19) pandemic poses many threats to healthcare workers in our country too, which leads to anxiety in healthcare workers. This study was conducted to explore the anxiety ... -
Exposure to electromagnetic field, cell phone use behaviors, SAR values, and changes in health following exposure in adolescent university students
Keleş, Ayşe İkinci; Şahin, Ceyda Uzun (Assoc Arquivos Neuro-Psiquiatria, 2021)Background: The use of technological devices is growing rapidly, and the use of cell phones increases in parallel. Dependence on technological devices is a particular factor in this increased exposure. Many studies have ... -
Gallic acid attenuates torsion/detorsion-induced testicular injury in rats through suppressing of HMGB1/NF- κB axis and endoplasmic reticulum stress
Demir, Selim; Kazaz, İlke Onur; Kerimoğlu, Gökçen; Alemdar, Nihal Türkmen; Çolak, Fatih; Arıcı, Tuğba; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel (Elsevier, 2024)It was aimed to evaluate whether gallic acid (GA) have a beneficial effect in the testicular ischemia/reperfusion injury (IRI) model in rats for the first time. Testicular malondialdehyde, 8-hydroxy-2 '-deoxyguanosine, ... -
Gentisic acid ameliorates cisplatin-induced reprotoxicity through suppressing endoplasmic reticulum stress and upregulating Nrf2 pathway
Menteşe, Ahmet; Demir, Selim; Aydın Mungan, Sevdegül; Alemdar, Nihal Türkmen; Ayazoğlu Demir, Elif; Aliyazıcıoğlu, Yüksel (Elsevier, 2023)Reproductive toxicity is a serious side effect of cisplatin (CP) chemotherapy. Gentisic acid (GTA) is a phenolic acid with strong antioxidant properties. Here, we aimed to determine therapeutic effect of GTA against ... -
Karbapeneme dirençli acinetobacter baumannii klinik izolatlarının moleküler epidemiyoloji açısından araştırılmasında üç farklı yöntemin karşılaştırılması
Bu çalışmada, karbapenem dirençli oksasilinaz tipi karbapenemaz genlerini taşıyan Acinetobacter baumannii izolatlarının “uluslararası yüksek riskli klonlar” (IC I, II ve III) ile ilişkisinin farklı moleküler epidemiyolojik ... -
p-Coumaric acid alleviates cisplatin-induced ovarian toxicity in rats
Ayazoğlu Demir, Elif; Menteşe, Ahmet; Küçük, Hatice; Türkmen Alemdar, Nihal; Demir, Selim (Wiley, 2021)Objective The therapeutic value of cisplatin (CDDP) as an anticancer drug is limited by its ovo-otoxicity. The effect of natural phenolic acids in the prevention of many diseases related to oxidative stress has been reported. ...