Yazar "Yalçın Özkat, Gözde" için PubMed İndeksli Yayınlar Koleksiyonu listeleme
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Computational studies with flavonoids and terpenoids as BRPF1 inhibitors: in silico biological activity prediction, molecular docking, molecular dynamics simulations, MM/PBSA calculations
Yalçın Özkat, Gözde (Taylor & Francis Ltd., 2022)The BRPF1 protein is encoded by the BRPF1 gene. In addition, the BRPF1 gene is known to be upregulated in leukaemia. Recent studies have shown that it is also overexpressed in hepatocellular carcinoma (HCC) as well. ... -
Design, synthesis and biological evaluation of novel bischalcone derivatives as potential anticancer agents
Burmaoğlu, Serdar; Göbek, Arzu; Aydın, Büşra Öztürk; Yurtoğlu, Emine; Aydın, Büşra Nur; Yalçın Özkat, Gözde; Hepokur, Ceylan; Şimşek Özek, Nihal; Ayşin, Ferhunde; Altuntaş, Ramazan; Algül, Öztekin (Elsevier, 2021)Building on our previous work that discovered chalcone as a promising pharmacophore for anticancer activity, we have various other chalcone derivatives and have synthesized a series of novel bischalcone to explore their ... -
Design, synthesis, and computational studies of benzimidazole derivatives as new antitubercular agents
Yalçın Özkat, Gözde; Ersan, Ronak H.; Ülger, Mahmut; Ülger, Seda T.; Burmaoğlu, Serdar; Yıldız, İlkay; Algül, Öztekin (Taylor & Francis Ltd., 2022)The increase in the drug-resistant strains of Mycobacterium tuberculosis has led researchers to new drug targets. The development of new compounds that have effective inhibitory properties with the selective vital structure ... -
Determination of novel SARS-CoV-2 inhibitors by combination of machine learning and molecular modeling methods
Güner, Ersin; Özkan, Özgür; Yalçın Özkat, Gözde; Ölgen, Süreyya (Bentham Science, 2023)Introduction: Within the scope of the project, this study aimed to find novel inhibitors by combining computational methods. In order to design inhibitors, it was aimed to produce molecules similar to the RdRp inhibitor ... -
Discovery of 5-(or 6)-benzoxazoles and oxazolo[4,5-b]pyridines as novel candidate antitumor agents targeting hTopo II alpha
Karataş, Esin; Foto, Egemen; Ertan Bolelli, Tuğba; Yalçın Özkat, Gözde; Yılmaz, Serap; Ataei, Şanaz; Zilifdar, Fatma; Yıldız, İlkay (Elsevier, 2021)Discovery of novel anticancer drugs which have low toxicity and high activity is very significant area in anticancer drug research and development. One of the important targets for cancer treatment research is topoisomerase ... -
Molecular modeling strategies of cancer multidrug resistance
Yalçın Özkat, Gözde (Elsevier, 2021)Cancer remains a leading cause of morbidity and mortality worldwide. Hence, the increase in cancer cases observed in the elderly population, as well as in children and adolescents, makes human malignancies a prime target ... -
Synthesis and molecular docking studies of some novel antimicrobial benzamides
Acar, Cemre; Yalçın Özkat, Gözde; Ertan-Bolelli, Tuğba; Onurdağ, Fatma Kaynak; Ökten, Suzan; Şener, Funda; Yıldız, İlkay (Academic Press Inc Elsevier Science, 2020)Common use of classical antibiotics has caused to the growing emergence of many resistant strains of pathogenic bacteria. Therefore, we aimed to synthesize a number of N-(2-hydroxy-(4 or 5)-nitrophenyl)benzamide derivatives ...