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Apelin-13 activates the hippocampal BDNF/TrkB signaling pathway and suppresses neuroinflammation in male rats with cisplatin-induced cognitive dysfunction
(Elsevier, 2021)
It has been established that cisplatin causes neuronal damage and cognitive impairment. However, the mechanism is not sufficiently clear. Apelin-13 is an endogenous peptide with strong neuroprotective effects through the ...
The effects of apelin-13 against cisplatin-induced nephrotoxicity in rats
(Taylo & Francis Ltd., 2021)
Acute kidney injury (AKI) is observed in nearly 60% of patients undergoing cisplatin (CP) therapy. The aim of this study was to reveal the potential effects of apelin-13 (AP-13) in the prevention of CP-induced renal toxicity, ...
Can dexmedetomidine be effective in the protection of radiotherapy-induced brain damage in the rat?
(Springer, 2021)
Approximately 7 million people are reported to be undergoing radiotherapy (RT) at any one time in the world. However, it is still not possible to prevent damage to secondary organs that are off-target. This study, therefore, ...
The effect of white tea on serum TNF-alpha/NF-kappa B and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2019)
Objective: Nephrotoxicity is the most important side effect of the antineoplastic drug cisplatin, thereby restricting its use. the aim of this study was to investigate the protective effects of white tea infusions(WT) ...
Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus
(Elsevier, 2023)
Cisplatin is a drug used effectively in the treatment of malignant tumors. However, cisplatin has many side ef-fects, including cognitive impairment. Agomelatine, a synthetic melatonin analogue, is an important antide-pressant. ...
Agomelatine on cisplatin-induced nephrotoxicity via oxidative stress and apoptosis
(Springer, 2023)
Drug-induced nephrotoxicity is the greatest deterrent to the use of cisplatin, which is a frequently used chemotherapeutic with
proven efectiveness in cancer therapy. Agomelatine, which is used in the treatment of sleep ...
Preventive effects of melatonin on periodontal tissue destruction due to psychological stress in rats with experimentally induced periodontitis
(Wiley, 2024)
Objective and Background: Psychological stress is a potential modifiable environmental risk factor causally related to the exacerbation of periodontitis and other chronic inflammatory diseases. This animal study aimed to ...
The impact of apelin-13 on cisplatin-induced endocrine pancreas damage in rats: an in vivo study
(Springer, 2024)
Apelin-13 is a peptide hormone that regulates pancreatic endocrine functions, and its benefits on the endocrine pancreas are of interest. This study aims to investigate the potential protective effects of apelin-13 in ...