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dc.contributor.authorÖzdemir, Ali
dc.contributor.authorBandırmalı, Osman
dc.date.accessioned2024-05-09T06:54:21Z
dc.date.available2024-05-09T06:54:21Z
dc.date.issued2024en_US
dc.identifier.citationÖzdemir, A. & Bandırmalı, O. (2024). Is there a predictive value of systemic inflammatory parameters and prognostic nutritional index in the detection of lymphatic metastases in papillary thyroid cancers?. Journal of Experimental and Clinical Medicine (Turkey), 41(1), 14-19. http://doi.org/10.52142/omujecm.41.1.3en_US
dc.identifier.issn1309-4483
dc.identifier.urihttp://doi.org/10.52142/omujecm.41.1.3
dc.identifier.urihttps://hdl.handle.net/11436/8996
dc.description.abstractThis study aimed to assess the predictive value of systemic inflammatory parameters and the prognostic nutritional index (PNI) in identifying lymphatic metastases in papillary thyroid cancers (PTC). PTCs, characterized by their in dolent nature and favorable prognosis, frequently disseminate to cervical lymphnodes, impacting recurrence and prognosis. However, the preoperative identification rate of cervical lymphnode metastases ranges from 20% to 75%, necessitating supplemental examinations for precise detection and surgical planning. A retrospective analysis of 441 thyroidectomy cases, encompassing 272 PTC patients, was conducted. Patients were categorized into two cohorts: 221 lacked lymphnode metastases, while 51 exhibited lymphatic metastases. Parameters including age, gender, systemic inflammatory markers derived from hemogram tests, serum albumin levels, and postoperative histopathology findings were scrutinized to evaluate the predictive potential of systemic inflammatory parameters and PNI in discerning between the two cohorts. The findings revealed that neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) values bore statistically significant predictive capacity (p<0.05) in preoperatively detecting cervical lymphnode metastases in PTC. Receiver operating characteristic (ROC) curves delineated the efficacy of NLR, PLR, and SII in prognostication. NLR exhibited an area under the curve (AUC) value of 0.932 (95% CI, 0.902-0.962; p<0.001), while PLR yielded an AUC value of 0.638 (95% CI, 0.555-0.721; p=0.002). SII analysis yielded an AUC value of 0.798 (95% CI, 0.736-0.861; p<0.001). Conversely, the prognostic nutritional index (PNI) demonstrated meager predictive utility, registering an AUC value of 0.192 (95% CI, 0.124-0.260; p<0.001), positioning below the reference line on the ROC curve. In conclusion, this study under scores NLR's utility in identifying cervical lymphnode metastases in PTC. While PLR and SII evince some association with lymphnode metastasis detection, their predictive efficacy remains constrained. Additionally, despite statistical significance, PNI exhibited in efficacy in forecasting lymphnode metastases.en_US
dc.language.isoengen_US
dc.publisherOndokuz Mayis Universitesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammatory markersen_US
dc.subjectLymph node metastasisen_US
dc.subjectPapillary thyroid carcinomasen_US
dc.subjectPrognostic nutritional indexen_US
dc.titleIs there a predictive value of systemic inflammatory parameters and prognostic nutritional index in the detection of lymphatic metastases in papillary thyroid cancers?en_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorÖzdemir, Ali
dc.contributor.institutionauthorBandırmalı, Osman
dc.identifier.doi10.52142/omujecm.41.1.3en_US
dc.identifier.volume41en_US
dc.identifier.issue1en_US
dc.identifier.startpage14en_US
dc.identifier.endpage19en_US
dc.relation.journalJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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