Ara
Toplam kayıt 12, listelenen: 1-10
Development of MoS2 and Au nanoparticle including disposable CEA-based immuno-cytosensor platforms
(Springer, 2022)
In this study, an electrochemical biosensor for determination of Carcinoembryonic antigen (CEA) biomarker using human breast ductal adenocarcinoma (MCF-7) and human ovarian adenocarcinoma (SK-OV-3) cancer cells was presented. ...
In silico studies to develop new GSK3 beta inhibitors effective in the 's disease
(Bentham Science Publications, 2022)
Background: Alzheimer's disease affects a large part of the world's population by prolonging the human life span and becoming an economic burden in the health system. Therefore, its treatment becomes more and more important ...
Computational studies with flavonoids and terpenoids as BRPF1 inhibitors: in silico biological activity prediction, molecular docking, molecular dynamics simulations, MM/PBSA calculations
(Taylor & Francis Ltd., 2022)
The BRPF1 protein is encoded by the BRPF1 gene. In addition, the BRPF1 gene is known to be upregulated in leukaemia. Recent studies have shown that it is also overexpressed in hepatocellular carcinoma (HCC) as well. ...
Syntheses, crystal structures, hirshfeld surface analyses and electrochemical etoposide/camptotechin sensor applications of acetaldehyde oxime derivatives
(Elsevier, 2022)
(E)-2-(4-Hydroxyphenyl)-2-oxoacetaldehyde oxime monohydrate (I) and (E)-2-(4 Nitropheny1)-2oxoacetaldehyde oximes (II) were synthesized from 4'-hydroxyacetophenone and 4'-nitroacetophenone, respectively. Their structures ...
Electrochemical properties of coumarin 500 encapsulated in a liquid crystal guided electrospun fiber core and their supercapacitor application
(Amer Chemical Soc., 2022)
Here, we first report a study on coumarin 500 and liquid crystal including polyacrylonitrile nanofibers in terms of synthesis, characterizations, and supercapacitor performances. SEM, POM, FTIR, and DSC measurements showed ...
Synthesis, molecular docking and some metabolic enzyme inhibition properties of biphenyl-substituted chalcone derivatives
(Elsevier, 2022)
The new synthesized biphenyl-substituted chalcone derivatives were evaluated against the human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. ...
Design, synthesis, and computational studies of benzimidazole derivatives as new antitubercular agents
(Taylor & Francis Ltd., 2022)
The increase in the drug-resistant strains of Mycobacterium tuberculosis has led researchers to new drug targets. The development of new compounds that have effective inhibitory properties with the selective vital structure ...
Synthesis, biological activities, antioxidant properties, and molecular docking studies of novel bis-schiff base podands as responsive chemosensors for anions
(Elsevier, 2022)
In this study, bis-carbonyl podand (triethylene glycol bis(2-carbonylphenyl)ether) ( 1 ) was synthesized from the reaction of triethylene glycol dichloride with salicylaldehyde. Then, Schiff base podans ( 2 and 3 ) were ...
In silico studies to develop new GSK3β inhibitors effective in the alzheimer's disease
(Bentham Science Publishers, 2022)
Background: Alzheimer's disease affects a large part of the world’s population by prolonging the human life span and becoming an economic burden in the health system. Therefore, its treatment be-comes more and more important ...
MS hastalığının tedavisine yönelik yeni Sfingosin-1-Fosfat reseptör modülatörlerinin geliştirilmesi
(Konya Teknik Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, 2022)
Hesaplamalı ilaç tasarımı; ilaç geliştirme prosesini hızlandırmakla birlikte maliyeti de düşürerek tıp
mühendisliğinin önde gelen alanlarından birine dönüşmüştür. MS hastalığı ölümle sonuçlanmasının yanı
sıra, hastalarda ...