Dendritic, water-soluble, and nonaggregated axially substituted silicon phthalocyanine as potential endometrial anticancer agent

Abstract

In this work, dendritic, water-soluble, and nonaggregated axially substituted silicon phthalocyanines (EA-TD-Si and EA-TD-SiQ) were synthesized and characterized. Then, the supercoiled pBR322 plasmid DNA damage properties of EA-TD-Si and EA-TD-SiQ were examined using agarose gel electrophoresis without light irradiation. In addition, the cytotoxicity and phototoxicity of EA-TD-Si and EA-TD-SiQ on human endometrium adenocarcinoma (HEC-1B) cells were investigated using an MTT assay. The results indicated that EA-TD-SiQ had high photodamage properties via singlet oxygen depending on the light dose, while EA-TD-Si did not show any DNA damage without light. In addition, EA-TD-SiQ had higher phototoxic effects than EA-TD-Si on HEC-1B cells according to the MTT assay. These results revealed the potential of EA-TD-SiQ to be used as a PDT agent in endometrial cancer.