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Noninvasive, serum-based evaluation of liver fibrosis in metabolic (dysfunction)-associated fatty liver disease

Erişim

info:eu-repo/semantics/closedAccess

Tarih

2024

Yazar

Kaya, Eda
Yılmaz, Yusuf

Üst veri

Tüm öğe kaydını göster

Künye

Kaya, E., & Yilmaz, Y. (2024). Noninvasive, serum-based evaluation of liver fibrosis in metabolic (dysfunction)-associated fatty liver disease. In Metabolic Steatotic Liver Disease (pp. 137–150). Elsevier. https://doi.org/10.1016/b978-0-323-99649-5.00012-1

Özet

Advanced hepatic fibrosis is the most relevant prognostic factor in patients with metabolic (dysfunction)–associated fatty liver disease (MAFLD), being a significant predictor of both liver-related and all-cause mortality. While liver biopsy remains the reference standard for the diagnosis of advanced fibrosis, several known shortcomings (e.g., invasive nature, interobserver variability, and procedural complications) ultimately limit its routine use in clinical practice. To overcome these issues, considerable attention has been recently devoted to identifying serum-based diagnostic panels, which may accurately detect liver fibrosis in a noninvasive fashion. In this chapter, we review the current status of serum-based modalities for the diagnosis and staging of liver fibrosis in patients with MAFLD and nonalcoholic fatty liver disease (NAFLD). Both serum-based noninvasive diagnostic panels, including Fibrosis-4 Index, NAFLD Score, and Aspartate Transaminase-to-Platelet Ratio, and panels comprising markers of collagen turnover and extracellular matrix remodeling parameters, including enhanced liver fibrosis test (ELF), FibroMeter, and FibroTest, will be examined. In general, simple serum-based models are initially used for excluding the presence of advanced fibrosis. In presence of indeterminate results, the use of diagnostic panels (e.g., ELF) or imaging modalities should be recommended as a second-level screening tool. However, diagnostic sensitivity remains suboptimal, and this should encourage future research aimed at optimizing overall accuracy.

Kaynak

Metabolic Steatotic Liver Disease: Current Knowledge, Therapeutic Treatments, and Future Directions

Bağlantı

https://doi.org/10.1016/b978-0-323-99649-5.00012-1
https://hdl.handle.net/11436/9370

Koleksiyonlar

  • Scopus İndeksli Yayınlar Koleksiyonu [5931]
  • TF, Dahili Tıp Bilimleri Bölümü Koleksiyonu [1559]

İlgili Öğeler

Başlık, yazar, küratör ve konuya göre gösterilen ilgili öğeler.

  • Epidemiology, natural history, and diagnosis of metabolic dysfunction-associated fatty liver disease: a comparative review with nonalcoholic fatty liver disease 

    Kaya, Eda; Yılmaz, Yusuf (Sage Publications, 2022)
    Metabolic (dysfunction)-associated fatty liver disease (MAFLD) is the most common chronic liver disease worldwide – with an estimated global prevalence of 37%. Different from nonalcoholic fatty liver disease (NAFLD), which ...
  • Asia-Pacific association for study of liver guidelines on management of ascites in liver disease 

    Singh, Virendra; De, Arka; Mehtani, Rohit; Angeli, Paolo; Maiwall, Rakhi; Satapathy, Sanjaya; Singal, Ashwini K.; Saraya, Anoop; Sharma, B. C.; Eapen, C. E.; Rao, P. N.; Shukla, Akash; Shalimar; Choudhary, Narendra S.; Alcantara-Payawal, Diana; Arora, Vinod; Aithal, Guru; Kulkarni, Anand; Roy, Akash; Shrestha, Ananta; al Mahtab, Mamun; Niriella, Madunil A.; Siam, Tan Soek; Zhang, Chun-Qing; Huei, Lee Guan; Yu, Ming-Lung; Roberts, Stuart K.; Peng, Cheng-Yuan; Chen, Tao; George, Jacob; Wong, Vincent; Yılmaz, Yusuf; Treeprasertsuk, Sombat; Kurniawan, Juferdy; Kim, Seung Up; Younossi, Zobair M.; Sarin, Shiv Kumar (Springer, 2023)
    The development of ascites is a landmark event in the natural history of cirrhosis.
  • Changes in the etiology of chronic liver disease by referral to a FibroScan center: Increasing prevalence of the nonalcoholic fatty liver disease 

    Eriş, Tansu; Hassan, Moomen; Hikal, Yousra; Sawah, Enas; Daneshgar, Fatemeh; Teker, Ayşe Gülşen; Özel, Furkan; Lüleci, Nimet Emel; Kaya, Eda; Yılmaz, Yusuf (Kare Publishing, 2023)
    Background and Aim: Chronic liver disease (CLD) is a leading cause of morbidity and mortality worldwide with a wide etiological spectrum. Fi-broScan (R) is used for follow-up of fibrosis and steatosis. This single -cen-ter ...



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