Yazar "RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü" için listeleme
-
Association of paraoxonase 1 (PON1) gene polymorphisms and concentration with essential hypertension
Coşan, Didem Turgut; Çolak, Emine; Saydam, Faruk; Yazıcı, Hüseyin uğur; Değirmenci, İrfan; Birdane, Alparslan; Çolak, Ertuğrul; Güneş, Hasan Veysi (Taylor & Francis Inc, 2016)Human serum paraoxonase 1 (PON1) is carried by high-density lipoprotein in blood circulation and is shown to be effective in preventing oxidized phospholipids carried by low-density lipoprotein particles, thus it acts as ... -
Association of paraoxonase-1 L55M and Q192R polymorphisms with PCOS risk and potential risk factors for atherosclerosis
Nalkıran, Hatice Sevim; Şahin, Serap Baydur; Ayaz, Teslime; Nalkıran, İhsan; Güzel, Ali İrfan; Eldeş, Tuğba; Yıldız, Yasin (Future Medicine Ltd, 2019)Aim: To examine the PON1-L55M and-Q192R polymorphisms for polycystic ovary syndrome (PCOS) risk in relation with atherosclerosis risk markers. Methods: Blood samples were collected from 203 women (PCOS [n = 151], control ... -
The association of Sort1 expression with LDL subfraction and inflammation in patients with coronary artery disease
Atak, Mehtap; Sevim Nalkıran, Hatice; Bostan, Mehmet; Uydu, Huseyin Avni (Taylor & Francis Ltd., 2023)Background: Controversial effect of sortilin on lipoprotein metabolism in the development of atherosclerosis reveals the need for more extensive research Objectives: The aim of this study was to investigate the association ... -
Autoantibodies against carbonic anhydrase I and II in patients with acute myeloid leukemia
Menteşe, Ahmet; Erkut, Nergiz; Demir, Selim; Yaman, Serap Özer; Sümer, Ayşegül; Doğramacı, Şeniz; Alver, Ahmet; Sönmez, Mehmet (2017)Amaç: Kanser, dünyadaki başlıca ölüm nedenlerinden birisi olup, küresel bir toplum sağlığı sorunudur. Organizmanın kendi antijenlerine karşı gelişen otoantikorlar pek çok kanser hastasının serumunda tespit edilmiştir. Son ... -
Avokado/soya fasülyesinin sabunlaşmayan ekstresi verilen köpeklerin dizlerinde osteokondral defekt iyileşmesi: Bir karşılaştırmalı morfometrik analiz
Altınel, Levent; Şahin, Önder; Köse, Kamil Çağrı; Baş, Orhan; Özen, Oğuz Aslan; Sarıtaş, Z. Kadir; Pamuk, Kamuran (2011)Amaç: Bu çalışmada avocado/soya fasülyesinin sabunlaşmayan ekstresinin (ASE) köpek osteokondral defekt modelinde iyileşmeye etkisi belirlendi. Gereç ve yöntemler: On dört köpek çalışmaya alındı ve rastgele olarak iki gruba ... -
Beta-lactamase genes in carbapenem resistance Acinetobacter baumannii isolates from a Turkish university hospital
Coşkun, Umut Safiye Say; Çalışkan, Emel; Çiçek, Ayşegül Çopur; Turumtay, Halbay; Sandallı, Cemal (J Infection Developing Countries, 2019)Introduction: the spread of Acinetobacter baumannii, resistant to most of the available antimicrobial agents, is a serious health problem. the high rate of carbapenem resistance among Acinetobacter baumannii isolates is ... -
Biochemical and histopathological investigation of liver tissues on high fat diet fed rats
Samancı, Tuğba Çelik; Gökçimen, Alpaslan; Kuloğlu, Tuncay; Boyacıoğlu, Murat; Kuyucu, Yurdun; Polat, Sait (Galenos Yayıncılık, 2022)Objective: Hepatic steatosis is a common cause of liver disease and has become more prevalent recently. This study was conducted to investigate the biochemical and histopathological changes in the liver tissue high fat ... -
Biochemical and pathological changes in the male rat kidney and bladder following exposure to continuous 900-MHz electromagnetic field on postnatal days 22-59
Türedi, Sibel; Kerimoğlu, Gökçen; Mercantepe, Tolga; Odacı, Ersan (Taylor & Francis Ltd, 2017)Purpose: To investigate the effect on male rat kidney and bladder tissues of exposure to 900-megahertz (MHz) electromagnetic field (EMF) applied on postnatal days 22-59, inclusive. Materials and methods: Twenty-four male ... -
Can dexmedetomidine be effective in the protection of radiotherapy-induced brain damage in the rat?
Çınar, Seda; Tümkaya, Levent; Mercantepe, Tolga; Saral, Sinan; Rakıcı, Sema; Yılmaz, Adnan; Topçu, Atilla; Şen, Ahmet; Karakaş, Sibel (Springer, 2021)Approximately 7 million people are reported to be undergoing radiotherapy (RT) at any one time in the world. However, it is still not possible to prevent damage to secondary organs that are off-target. This study, therefore, ... -
Can prenatal exposure to a 900 MHz electromagnetic field affect the morphology of the spleen and thymus, and alter biomarkers of oxidative damage in 21-day-old male rats?
Hancı, Hatice; Türedi, Sibel; Topal, Zehra Suzan; Mercantepe, Tolga; Bozkurt, İlyas; Kaya, Haydar; Ersöz, Şafak; Ünal, Bünyamin; Odacı, Ersan (Taylor & Francis Ltd, 2015)We investigated the effects of a 900 Megahertz (MHz) electromagnetic field (EMF), applied during the prenatal period, on the spleen and thymus of 21-day-old male rat pups. Pregnant Sprague-Dawley rats were divided into ... -
Carbonic anhydrase I and II autoantibodies in Behcet's disease
Mentese, Ahmet; Alver, Ahmet; Demir, Selim; Sümer, Ayşegül; Özer Yaman, Serap; Karkucak, Murat; Aydın Çapkın, Arzu; Us Altay, Diler; Turan, İbrahim (Publisaude-Edicoes Medicas Lda, 2017)Background: Behcet's disease ( BD) is a vasculitis, seen more frequently around the Mediterranean and the Far East, and evinces with oral and genital ulcerations, skin lesions and uveitis. Carbonic anhydrase ( CA) is a ... -
Carriage of class 1 and 2 integrons in acinetobacter baumannii and pseudomonas aeruginosa isolated from clinical specimens and a novel gene cassette array: bla(OXA-11)-cmlA7
Mengeloğlu, Fırat Zafer; Çiçek, Ayşegül Çopur; Koçoğlu, Esra; Sandallı, Cemal; Budak, Emine Esra; Özgümüş, Osman Birol (Ankara Microbiology Soc, 2014)The dissemination of antibiotic resistance genes between bacteria leads to serious problems in the treatment of infectious diseases. It has been shown that resistance genes can also be carried by the integrons. There are ... -
Changes in testicular morphology and oxidative stress biomarkers in 60-day-old Sprague Dawley rats following exposure to continuous 900-MHz electromagnetic field for 1 h a day throughout adolescence
Hancı, Hatice; Kerimoğlu, Gökçen; Mercantepe, Tolga; Odacı, Ersan (Pergamon-Elsevier Science Ltd, 2018)The purpose of this study was to investigate the 60-day-old male rat testis following exposure to continuous 900-megahertz (MHz) electromagnetic field (EMF) throughout the adolescent period using histopathological and ... -
Characterization of class 1 and class 2 integron gene cassettes in escherichia coil strains isolated from urine cultures: A multicenter study
Çopur Çiçek, Ayşegül; Sandallı, Cemal; Budak, Emine Esra; Yağmur, Gülhan; Çizmeci, Zeynep; Ak, Sibel; Balcı, Pervin Özlem; Say Coşkun, Safiye Umut; Ay Altıntop, Yasemin; Fırat, Mehmet; Sarı, Fatma; Çalışkan, Ahmet; Yıldız, Nazan; Sancaktar, Metin; Özgümüş, Osman Birol (Ankara Microbiology Soc, 2016)Escherichia coli is the most common pathogen isolated from both nosocomial and community acquired urinary tract infections. Although there are many studies from different centers concerning the antibiotic susceptibility ... -
Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing beta-lactamases in Pseudomonas aeruginosa in Turkey
Iraz, Meryem; Düzgün, Azer Özad; Çiçek, Ayşegül Çopur; Bonnin, Remy A.; Ceylan, Ayşenur; Saral, Ayşegül; Nordmann, Patrice; Sandalli, Cemal (Elsevier Science Inc, 2014)Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), ... -
Cholesterol forms and traditional lipid profile for projection of atherogenic dyslipidemia: lipoprotein subfractions and erythrocyte membrane cholesterol
Uydu, Hüseyin Avni; Bostan, Mehmet; Atak, Mehtap; Yılmaz, Adnan; Demir, Adem; Akcan, Buket; Sümer, Fatih; Baltaş, Nimet; Karadağ, Zakir; Uğurlu, Yavuz; Örem, Asım (Springer, 2014)Atherogenic dyslipidemia characterized by abnormal changes in plasma lipid profile such as low high-density lipoprotein (HDL) and increased triglyceride (TG) levels is strongly associated with atherosclerotic diseases. We ... -
Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation
Üçüncü, Yılmaz; Çelik, Nuray; Öztürk, Cengiz; Türkoğlu, Murat; Çetin, Nihal; Koçkara, Nizamettin; Şener, Ebru; Dündar, Cihat; Arslan, Aynur; Doğan, Hasan; Kurt, Nezahat; Süleyman, Halis (Pergamon-Elsevier Science Ltd, 2015)Aims: This study investigates the effect of a new combination of glucosamine hydrochloride, chondroitin sulfate, methylsulfonylmethane, Harpagophytum procumbens root extract (standardized to 3% harpagoside) and bromelain ... -
Chromosomal findings and sequence analysis of target exons of calcium-sensing receptor (CaSR) gene in patients with Sagliker syndrome
Tunç, Erdal; Demirhan, Osman; Sağlıker, Yahya; Yıldız, İsmail; Paylar, Nuray; Güzel, Ali İrfan (2017)Background/aim: Sagliker syndrome (SS) develops as a continuation of chronic kidney disease and secondary hyperparathyroidism conditions. It was thought that there are some genetic predisposition factors leading to SS. The ... -
Chronic prenatal exposure to the 900 megahertz electromagnetic field induces pyramidal cell loss in the hippocampus of newborn rats
Bas, O.; Odacı, E.; Mollaoğlu, H.; Üçok, K.; Kaplan, S. (Sage, 2009)Widespread use of mobile phones which are a major source of electromagnetic fields might affect living organisms. However, there has been no investigation concerning prenatal exposure to electromagnetic fields or their ... -
Chronic restraint stress impairs spatial memory while decreasing hippocampal BDNF levels in rats
Saral, Sinan; Sümer, Ayşegül; Kaya, Ali Koray; Öztürk, Aykut; Topçu, Atilla (İnönü Üniversitesi Tıp Fakültesi, 2022)Aim: This study investigated the potential role of chronic restraint stress (CRS) on spatial memory, recognition memory, brain-derived neurotrophic factor (BDNF) and acetylcholine (ACh) levels in young adult rats. Material ...