Yazar "Demirbaş, Neslihan" için listeleme
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Structure-based hybridization, microwave prompted synthesis and biological evaluation of novel 4-(2-fluoro-4-nitrophenyl)morpholine derivatives
Cebeci, Yıldız Uygun; Demirbaş, Neslihan; Özdemir, Serap Başoğlu; Bayrak, Hacer; Demirbaş, Ahmet; Aksakal, Fatma; Karaoğlu, Şengül Alpay (Bentham Science Publ Ltd, 2018)1,3,4-oxadiazole-2-thiole 6 was obtained from 4-(2-fluoro-4-nitrophenyl)morpholine (2) by the reduction of its nitro group and the sequential treatment of the resulting amine with ethyl bro-moacetate, hydrazine hydrate, ... -
Syntheses and biological activities of new hybrid molecules containing different heterocyclic moieties
Ceylan, Şule; Bektaş, Hakan; Bayrak, Hacer; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay; Ülker, Serdar (Wiley, 2013)4-Aryl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-(thi)oles 5-7, obtained starting from nicotinic acid hydrazide were converted to the corresponding Mannich bases 12-24 by the reaction with several heterocyclic amines in the ... -
Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives
Bektaş, Hakan; Karaali, Nesrin; Şahin, Deniz; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (MDPI, 2010)Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbo ... -
Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives
Bayrak, Hacer; Demirbaş, Ahmet; Bektaş, Hakan; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (TUBİTAK, 2010)The synthesis of ethyl [3-(cyanomethyl)-5-alkyl-4H-1,2,4-triazol-4-yl] carbamates (2a-d) was performed starting from ethyl 2-[ethoxy(4-(aryl)methylene] hydrazinecarboxylates (1a, 1b). The treatment of 2a with thiosemicarbazide ... -
Synthesis and antimicrobial activities of some new biheterocyclic compounds containing 1, 2, 4-triazol-3-one and 1, 3, 4-thiadiazole moieties
Bektaş, Hakan; Demirbaş, Ahmet; Demirbaş, Neslihan; Bayrak, Hacer; Karaoğlu, Şengül Alpay (TÜBİTAK, 2010)2-(4-Amino-3-(4-chlorophenyl)-5-oxo-4, 5-dihydro-1 H-1, 2, 4-triazol-1-yl)-N'-[(2, 6 dihalogenophenyl)-methylene]acetohydrazides (3a, b) was obtained via the formation of 2-(4-amino-3-(4-chlorophenyl)-5-oxo-4, 5-dihydro-1 ... -
Synthesis and antimicrobial activity evaluation of new norfloxacine-azole hybrids
Demirci, Serpil; Demirbaş, Neslihan; Menteşe, Meltem; Özdemir, Serap Başoğlu; Karaoğlu, Şengül Alpay (Walter de Gruyter Gmbh, 2018)Norfloxacin-azole hybrids 3 and 6a,b were synthesized starting from norfloxacin. the treatment of these compounds with amines as a one-pot three-component reaction produced the corresponding amino derivatives 4a,b, 7a-g ... -
Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds
Özdemir, Serap Başoğlu; Cebeci, Yıldız Uygun; Bayrak, Hacer; Mermer, Arif; Ceylan, Şule; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (Walter de Gruyter Gmbh, 2017)The hydrazide 5, that was obtained from -1-(4-fluorophenyl) piperazine (1), was converted to the cor-responding carbothioamides 6a-c by the reaction with alkyl(aryl) isothiocyanates. the synthesis of conazole analogs 10a-f ... -
Synthesis and biological activity studies of new hybrid molecules containing tryptamine moiety
Bektaş, Hakan; Demirbaş, Ahmet; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (Springer, 2012)The synthesis of N?-(4-substitutedphenylsulfonyl)-2-{4-[2-(1H-indol- yl)ethyl]-3-(4-chlorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl} acetohydrazides (3a-c), 2-{4-[2-(1H-indol-3-yl)ethyl]-3-(4-chlorobenzyl)-5-oxo- ... -
Synthesis of novel Azol-beta-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies
Mermer, Arif; Bayrak, Hacer; Şirin, Yakup; Emirik, Mustafa; Demirbaş, Neslihan (Elsevier Science Bv, 2019)This study reports the synthesis, biological investigation and molecular docking of novel beta-lactam derivatives bearing 1,3,4-thiadiazole and 1,3,4-oxadiazole ring system. the synthesized compounds were evaluated for in ... -
Synthesis of some heterofunctionalized penicillanic acid derivatives and investigation of their biological activities
Demirci, Serpil; Demirbaş, Ahmet; Ülker, Serdar; Alpay-Karaoğlu, Şengül; Demirbaş, Neslihan (Wiley-V C H Verlag Gmbh, 2014)6-Substituted amino-penicillanic acid esters were synthesized starting with 6-apa. the compounds containing a 1,3-thiazole- or 1,3-thiazolidinone nucleus linked to the penicillanic acid skeleton via a hydrazino linkage ... -
Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation of their antimicrobial activities
Bayrak, Hacer; Demirbağ, Ahmet; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (Elsevier, 2009)5-Pyridin-4-yl-1,3,4-oxadiazole-2-thiol (2) was obtained from the reaction of isonicotinic acid hydrazide with carbon disulfide in basic media and converted into 4-amino-5-pyridin-4-yl-4H-1,2,4-triazole-3-thiol (5) by the ... -
Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities
Bayrak, Hacer; Demirbaş, Ahmet; Karaoğlu, Şengül Alpay; Demirbaş, Neslihan (Elsevier, 2009)4-Phenyl-5-pyridin-4-yl-4H-1,2,4-triazole-3-thiol (3) was obtained in basic media via the formation of 2-isonicotinoyl-N-phenylhydrazinecarbothioamide (2), and converted to some alkylated derivatives (4a,b) and Mannich ... -
Synthesis of some new 1,3,4-thiadiazol-2-ylmethyl-1,2,4-triazole derivatives and investigation of their antimicrobial activities
Demirbaş, Ahmet; Şahin, Deniz; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (Elsevier, 2009)4-Amino-2-[(5-arylamino-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-5-(4-methylphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-ones (3a-c) were obtained in acidic media via the formation of 2-[(4-amino-3-aryl-5-oxo-4,5-dihydro-1H-1 ... -
Synthesis of some new biheterocyclic triazole derivatives and evaluation of their antimicrobial activity
Bektaş, Hakan; Demirbaş, Ahmet; Demirbaş, Neslihan; Karaoğlu, Şengül Alpay (TÜBİTAK, 2010)2-{3-(4-Substitutedbenzyl)-4-[2-(1H-indol-3-yl)ethyl]-5-oxo-4, 5-dihydro-1H-1,2,4-triazol-1-yl}-N' -(arylmethylene) acetohydrazides (5a-g), 4-amino-2-{3-(4-substitutedbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1- yl}-N' ... -
Synthesis of Some New Ciprofloxacin Hybrids as Potential Antimicrobial Agents
Menteşe, Meltem; Beriş, Fatih Şaban; Demirbaş, Neslihan (Wiley, 2017)A new series of ciprofloxacin hybrid compounds as new type of antimicrobial agents were synthesized and evaluated for antibacterial activity against Gram-positive and Gram-negative bacteria. -
Synthesis of some new hybride molecules containing several azole moieties and investigation of their biological activities
Ceylan, Şule; Bayrak, Hacer; Demirbaş, Ahmet; Ülker, Serdar; Alpay-Karaoğlu, Şengül; Demirbaş, Neslihan (Maik Nauka/Interperiodica/Springer, 2014)1,2,4-Triazole-3-one prepared from tryptamine was converted to the corresponding carbothioamides by several steps. Their treatment with ethyl bromoacetate or 4-chlorophenacyl bromide produced the corresponding 5-oxo-1,3- ...