Yazar "Tümkaya, Levent" için listeleme
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The effects of TNF-alpha inhibitors on carbon tetrachloride-induced nephrotoxicity
Özdemir, Ali; Tümkaya, Levent; Kalcan, Süleyman; Uyan, Mikail; Karakaya, Ahmet; Demiral, Gökhan; Samancı, Tuğba Çelik; Mercantepe, Tolga; Cüre, Medine Cumhur; Cüre, Erkan (Taylo & Francis Ltd., 2021)Objectives: Carbon tetrachloride (CCl4), employed in various industrial fields, can cause acute damage in renal tissues. This study investigated the therapeutic effect of the TNF-alpha inhibitor Infliximab on TGF-beta and ... -
The effects of topiramate on methotrexate- induced pancreatic injury
Mercantepe, Filiz; Tümkaya, Levent (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültes, 2023)Amaç: Bu çalışmada metotreksat ilişkili pankreas hasarında topiramatın pankreasın Langerhans adacık hücreleri üzerine olan etkisinin araştırılması amaçlandı. Gereçler ve Yöntem: Çalışma 04 Temmuz- 24 Temmuz 2022 tarihinde ... -
The effects of white tea (Camellia Sinensis) and infliximab against cisplatin-induced testicular damage via oxidative stress and apoptosis
Çakıroğlu, Şenay; Mercantepe, Tolga; Tümkaya, Levent; Uydu, Hüseyin Avni; Topçu, Atilla; Atak, Mehtap (2023)Cisplatin (Cis) is an important chemotherapeutic agent used in cancer treatment. Males exposed to Cis were reported to exhibit testicular toxicity. Cis-induced testicular toxicity is mediated by oxidative stress, inflammation, ... -
The effects of whortleberry on ischemia reperfusion-induced myocardial injury in rats
Karakişi, Sedat Ozan; Hemşinli, Doğuş; Ergene, Şaban; Mercantepe, Tolga; Tümkaya, Levent; Yılmaz, Adnan (2020)Background: The aim of this study was to investigate the potential protective effect of whortleberry by examining the effects on heart tissue at the molecular level of ischemia-reperfusion injury caused by surgical repair ... -
Evaluation of the effects of dexmedetomidine on liver damage secondary to renal ischemia-reperfusion
Kartal, Seyfi; Şen, Ahmet; Tümkaya, Levent; Abdullah, Özdemir; Tolga, Mercantepe; Adnan, Yılmaz (Anaesthesia Pain & Intensive Care, 2020)Background: the aim of this study was to evaluate the hepatic protective effects of dexmedetomidine in a rat model of renal ischemia-reperfusion (I/R) injury. Methodology: We selected 18 albino rats and randomly divided ... -
Evaluation of the protective effects of amifostine and melatonin against cisplatin induced testis injury via oxidative stress and apoptosis in rats
Eren, Hüseyin; Mercantepe, Tolga; Tümkaya, Levent; Mercantepe, Filiz; Dil, Eyüp; Horsanali, Mustafa Ozan; Yılmaz, Adnan (Academic Press Inc Elsevier Science, 2020)..... -
Gene expression and histopathological evaluation of thiamine pyrophosphate on optic neuropathy induced with ethambutol in rats
Çinici, Emile; Çetin, Nihal; Süleyman, Bahadır; Altuner, Durdu; Yaralı, Oğuzhan; Balta, Hilal; Çalık, İlknur; Tümkaya, Levent; Süleyman, Halis (Ijo Press, 2016)AIM: To compare the effects of thiamine pyrophosphate (TPP) and thiamine (TM) in oxidative optic neuropathy in rats induced by ethambutol. METHODS: the animals were divided into four groups: a control group (CG), an ... -
Grading of epidural fibrosis in a new rabbit experimental model for epidural adhesive scar tissue formation
This experimental study was planned to evaluate the success of rabbit hemilaminotomy procedure and proposing of a new grading system in the evaluation of epidural fibrosis. Fourteen New Zealand white rabbits were used in ... -
Hepatic effects of ketamine administration for 2 weeks in rats
Kalkan, Yıldıray; Tomak, Yakup; Altuner, Durdu; Tümkaya, Levent; Bostan, Habib; Yılmaz, Adnan; Ünal, D.; Kara, A.; Turan, A. (Sage Publishing, 2014)The aim of the present study was to investigate the long-term and high-dose application of ketamine on the liver by employing histologic and biochemical methods. A total of 30 male rats were randomly assigned to control ... -
The hepatoprotective potential of resveratrol in an experimental model of ruptured abdominal aortic aneurysm via oxidative stress and apoptosis
Bilen, Arzu; Mercantepe, Filiz; Tümkaya, Levent; Yılmaz, Adnan; Batçık, Şule (Wiley, 2021)The mortality rate in ruptured abdominal aortic aneurysms can today be reduced through cardiovascular surgery. However, ischemia and reperfusion-induced tissue damage develop due to aortic cross-clamping applied during ... -
The hepatoprotective potential of resveratrol in an experimental model of ruptured abdominal aortic aneurysm via oxidative stress and apoptosis
Bilen, Arzu; Mercantepe, Filiz; Tümkaya, Levent; Yılmaz, Adnan; Batçık, Şule (Wiley, 2021)The mortality rate in ruptured abdominal aortic aneurysms can today be reduced through cardiovascular surgery. However, ischemia and reperfusion-induced tissue damage develop due to aortic cross-clamping applied during ... -
High dose zoledronic acid increases ischemia-reperfusion damage of the liver
Aydın, İbrahim; Şehitoğlu, İbrahim; Özer, Emel; Kalkan, Yıldıray; Tümkaya, Levent; Cüre, Medine Cumhur; Cüre, Erkan (Verduci Publisher, 2021)OBJECTIVE: Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, has been reported to exhibit a protective effect against cancers and prevent bone fractures. It also induces apoptosis by increasing proinflammatory ... -
Histopathological evaluation of the effects of dexmedetomidine against pituitary damage ınduced by X-ray irradiation
Mercantepe, Filiz; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema (Taylor & Francis Ltd., 2022)Background: The present study, aimed to investigate the potential negative effects of x-ray radiation and the effects of the α2-adrenergic receptor agonist dexmedetomidine on the pituitary gland. Methods: Twenty-four ... -
The impact of apelin-13 on cisplatin-induced endocrine pancreas damage in rats: an in vivo study
Çiftel, Serpil; Tümkaya, Levent; Saral, Sinan; Mercantepe, Tolga; Akyıldız, Kerimali; Yılmaz, Adnan; Mercantepe, Tolga (Springer, 2024)Apelin-13 is a peptide hormone that regulates pancreatic endocrine functions, and its benefits on the endocrine pancreas are of interest. This study aims to investigate the potential protective effects of apelin-13 in ... -
Infliximab modulates cisplatin-induced hepatotoxicity in rats
Cüre, Medine Cumhur; Cüre, Erkan; Kalkan, Yıldıray; Kırbaş, Aynur; Tümkaya, Levent; Yılmaz, Arif; Türkyılmaz, Ayşegül Küçükali; Sehitoğlu, İbrahim; Yüce, Süleyman (Galenos Publ, 2016)Background: Cisplatin (Cis) is one of the most com-monly used antineoplastic drugs. It is used as chemo-therapy for many solid organ malignancies such as brain, neck, male and female urogenital, vesical and pulmonary ... -
Influence of infliximab pretreatment on ischemia/reperfusion injury in rat intestine
Akdoğan, Remzi Adnan; Kalkan, Yıldıray; Tümkaya, Levent; Alacam, Hasan; Erdivanlı, Başar; Aydın, İbrahim (Via Medica, 2014)The Pringle maneuver is used in hepatic surgery to prevent blood loss but is associated with ischemia-reperfusion injury. To investigate the effect of infliximab on inflammation and apoptosis in rat intestinal mucosa during ... -
Influences of periodontitis on hippocampal inflammation, oxidative stress, and apoptosis in rats
Köse, Oğuz; Altın, Ahmet; Bayrakdar, Sevda Kurt; Bostan, Semih Alperen; Mercantepe, Tolga; Akyıldız, Kerimali; Tümkaya, Levent; Yılmaz, Adnan; Köse, Sefanur; Yemenoğlu, Hatice; Şener, Leyla Türker; Göker, Kuluslu (Wiley, 2021)Background and aim The hippocampus, which has a central role in cognitive and behavioral activities, is one of the most sensitive parts of the brain to systemic inflammatory diseases. This animal study aims to comprehensively ... -
Inhibition of methotrexate induced toxicity in the adult rat spleen by adalimumab
Bahçeci, İlkay; Tümkaya, Levent; Mercantepe, Tolga; Aslan, Nuray; Duran, Ömer Faruk; Söztanacı, Umut Serkan; Yazıcı, Zihni Açar (Taylor & Francis Ltd., 2022)Methotrexate (MTX) has been in use for the treatment of rheumatoid arthritis (RA), psoriasis, and cancer since 1948. Its toxic side effects on tissues and organs have been well documented but splenotoxicity has not been ... -
An investigation of the effects of metformin on ovarian ischemia-reperfusion injury in rats
Topçu, Atilla; Balık, Gülşah; Atak, Mehtap; Mercantepe, Tolga; Uydu, Hüseyin Avni; Tümkaya, Levent (Elsevier, 2019)Damage to the ovaries or tissue torsion can significantly reduce the ovarian reserve and thus cause severe gynecological and hormonal deficiencies. the discovery of new agents is always needed in the treatment of this ... -
An investigation of the effects of N-acetylcysteine on radiotherapy-induced testicular injury in rats
Topçu, Atilla; Mercantepe, Filiz; Rakıcı, Sema; Tümkaya, Levent; Uydu, Hüseyin Avni; Mercantepe, Tolga (Springer, 2019)According to data issued by the International Agency for Research on Cancer in 2012, the estimated number of new cases of all types of cancer worldwide was estimated to exceed 10 million, and 6 million of whom receive ...
