Yazar "RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü" için listeleme
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Abdominal aorta and its branches: Morphometry - Variations in autopsy cases
Songür, Ahmet; Toktaş, Muhsin; Alkoç, Ozan; Acar, Tolgahan; Uzun, İbrahim; Baş, Orhan; Özen, Oğuz Aslan (Tıp Araştırmaları Derneği, 2010)Aim: Knowing the morphology of abdominal aorta (AA) and its branches are important as regards to diagnosis and surgical treatment. The aims of this study were to a) make morphometric measurements of AA and its branches, ... -
Acute renal involvement in organophosphate poisoning: histological and immunochemical investigations
Kaya, Yasemin; Baş, Orhan; Hancı, Hatice; Çankaya, Soner; Nalbant,İsmail; Odacı, Ersan; Uydu, Hüseyin Avni; Aslan, Ali (Taylor & Francis Ltd, 2018)Purpose: Today, the long-term effects of partial exposure of cholinesterase on the kidney continue to be a research topic. in this study, we aimed to histopathologically investigate the possible effect of acute toxicity ... -
Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus
Saral, Sinan; Topçu, Atilla; Alkanat, Mehmet; Mercantepe, Tolga; Şahin, Zafer; Akyıldız, Kerimali; Karataş, Kader Semra; Yıldız, Lamiye; Tümkaya, Levent; Yazıcı, Zihni Açar (Elsevier, 2023)Cisplatin is a drug used effectively in the treatment of malignant tumors. However, cisplatin has many side ef-fects, including cognitive impairment. Agomelatine, a synthetic melatonin analogue, is an important antide-pressant. ... -
Agomelatine reverses scopolamine-ınduced learning and memory impairment in adult rats
Saral, Sinan; Kaya, Ali Koray; Topçu, Atilla; Öztürk, Aykut; Sümer, Ayşegül; Pınarbaş, Esra (Sakarya Üniversitesi, 2021)Amaç: Agomelatin, melatonin reseptör (MT1 ve MT2) agonisti ve serotonin reseptör (5-HT2C) antagonisti olan antidepresan bir ilaçtır. Artan kanıtlar, agomelatinin nöroprotektif ve nöromodülatör etkiye sahip olduğunu ... -
Akut mezenterik iskemi tanılı hastanın operasyon sonrası nazogastrik sondasından çıkan Ascaris lumbricoides: Olgu sunumu
Ascaris lumbricoides insanlarda sık rastlanan barsak helmintidir. Bu, özellikle sıcak ve kırsal bölgelerde, sosyoekonomik düzeyi düşük toplumları etkileyen bir parazittir. Ascaris lumbricoides, parazitin hareketliliği ... -
Analysis of cytokine gene polymorphism allelic variation in the Turkish population with inflammatory bowel disease
Gök, Ilhami; Uçar, Fahri; Özgür, Orhan; Efe, Hasan (Allied Acad, 2014)Inflammatory bowel diseases (IBD), Crohn's Disease (CD) and Ulcerative Colitis (UC) are complex diseases showing genetic heterogeneity that arise with the interaction of the genetic and environmental agents. the prevalence ... -
Anatomic variations of sphenoid sinus pneumatization in a sample of Turkish Population: MRI study
Sevinç, Özdemir; İs, Merih; Barut,Çağatay; Erdoğan, Alirıza (Soc Chilena Anatomia, 2014)There are a number of variations regarding morphometric anatomy and degree of pneumatization of the sphenoid sinus. in our study, we planned to examine and show the differences of pneumatization of the sphenoid sinus ... -
Antibiotic sensitivity of Stenotrophomonas maltophilia in a 5-year period and investigation of clonal outbreak with PFGE
Çalışkan, Ahmet; Çiçek, Ayşegül Çopur; Ejder, Nebahat Aydoğan; Karagöz, Alper; Kirişçi, Özlem; Kılıç, Selçuk (J Infection Developing Countries, 2019)Introduction: Stenotrophomonas maltophilia, which is able to form a biofilm, has mostly been related to catheters when it is the agent in hospital infections; these infections generally present as bacteremia and pneumonia, ... -
Anticancer effects of a novel herbal combination as a potential therapeutic candidate against lung cancer
Saydam, Faruk; Nalkıran, Hatice Sevim (Elsevier Science, 2021)Introduction: Cancer continues to be a prevalent health problem with increasing mortality rates. The interest in complementary medicine for cancer treatment has increased in recent years. In this study, we aimed to investigate ... -
Antimicrobial resistance patterns and integron carriage of escherichia coli isolates causing community-acquired infections in Turkey
Çiçek, Ayşegül Çopur; Özgümüş, Osman Birol; Saral, Ayşegül; Sandallı, Cemal (Korean Soc Laboratory Medicine, 2014)We aimed to observe antimiCrobial resistance patterns and integron carriage of Escherichia coli isolates causing community-acquired infections. Two hundred sixty-eight E. coli strains were obtained from outpatients with ... -
Antimicrobial susceptibility and molecular characterization of multidrug-resistant acinetobacter baumannii isolated in an university hospital
Direkel, Şahin; Çiçek, Ayşegül Çopur; Karagöz, Alper; Aydoğan Ejder, Nebahat; Oktay, Efdal; Delialioğlu, Nuran; Özgümüş, Osman Birol; Durmaz, Rıza (Ankara Microbiology Soc, 2016)Acinetobacter baumannii, an aerobic, non-motile, gram-negative bacterium is an important nosocomial pathogen which shows resistance to the most antibiotics. Carbapenems are the most commonly used antibiotics for the treatment ... -
Antioxidative status and lipid peroxidation in kidney tissue of rats fed with vitamin B6-deficient diet
Keleş, Mustafa; Al, Behçet; Gümüştekin, Kenan; Demircan, Berna; Özbey, İsa; Akyüz, Mehmet; Yılmaz, Adnan; Demir, Elif; Uyanık, Abdullah; Zipyak, Tevfik; Taysi, Seyithan (Taylor & Francis, 2010)Introduction: The aim of this study was to evaluate lipid peroxidation (LP) and free radical scavenging enzyme activities in kidney tissue of vitamin B6-deficient rats. Material and Methods: The rats were divided into ... -
Apelin-13 activates the hippocampal BDNF/TrkB signaling pathway and suppresses neuroinflammation in male rats with cisplatin-induced cognitive dysfunction
Saral, Sinan; Topçu, Atilla; Alkanat, Mehmet; Mercantepe, Tolga; Akyıldız, Kerimali; Yıldız, Lamiye; Tümkaya, Levent; Yazıcı, Zihni Açar; Yılmaz, Adnan (Elsevier, 2021)It has been established that cisplatin causes neuronal damage and cognitive impairment. However, the mechanism is not sufficiently clear. Apelin-13 is an endogenous peptide with strong neuroprotective effects through the ... -
Apelin-13 increased food intake with serum ghrelin and leptin levels in male rats
Saral, Sinan; Alkanat, Mehmet; Sümer, Ayşegül; Canpolat, Sinan (Comenius Univ, 2018)In this study, we aimed to explain the role of apelin-13 on body weight, food and water intake with serum leptin, ghrelin, neuropeptid Y (NPY) and peptid YY (PYY) levels in male rat. Thirty-two Sprague-Dawley male rats ... -
Are there fetal stem cells in the maternal brain?
Demirhan, Osman; Çekin, Necmi; Taştemir, Deniz; Tunç, Erdal; Güzel, Ali İrfan; Meral, Demet; Demirbek, Bülent (Wolters Kluwer Medknow Publications, 2013)Fetal cells can enter maternal blood during pregnancy but whether they can also cross the blood-brain barrier to enter the maternal brain remains poorly understood. Previous results suggest that fetal cells are summoned ... -
Assessment of association rule mining using ınterest measures on the gene data
Akbaş, Kübra Elif; Kıvrak, Mehmet; Arslan, Ahmet Kadir; Yakınbaş, Tuğçe; Korkmaz, Hasan; Önalan, Ebru (Medical records-international medical journal, 2022)Aim: Data mining is the discovery process of beneficial information, not revealed from large-scale data beforehand. One of the fields in which data mining is widely used is health. With data mining, the diagnosis and ... -
Assessment of element concentration distribution in different rat organs by wavelength dispersive x-ray fluorescence: Effects of Aluminum chloride
Akbaba, Uğur; Arslan, M. Enes; Çelik, Kübra; Türkez, Hasan; Akbaba, G. Buğra (Parlar Scientific Publications (P S P), 2018)Aluminum (Al) is present on earth surface has different chemical forms. It is a toxic metal and it may cause different disorders such as osteomalacia, microcytic anemia, Alzheimer and Parkinson's disease. Thus, it is very ... -
The assessment of neuronal plasticity following sciatic nerve injuries in rats using electron microscopy and stereological methods
Delibaş, Burcu; Vianney, John-Mary; Kaplan, Süleyman (Elsevier, 2024)The transmission of signals to the cell body from injured axons induces significant alterations in primary sensory neurons located in the ganglion tissue, the site of the perikaryon of the affected nerve fibers. Disruption ... -
Association and haplotype analysis of the PON1, ITGB3 and CYP3A4 genes, strong candidates for familial coronary artery disease susceptibility
Saydam, Faruk; Değirmenci, İrfan; Birdane, Alparslan; Özbayer, Cansu; Ulus, Taner; Özdemir, Mahmut; Ata, Necmi; Güneş, Hasan Veysi (2023)Objective: Genetic predisposition is very common among the patients with coronary artery disease (CAD), a complex and multifactorial disease. Our objective was to determine the possible association between the most ... -
Association between rs11362 polymorphism in the beta-defensin 1 (DEFB1) gene and dental caries: A meta-analysis
Hatipoğlu, Ömer; Saydam, Faruk (Elsevier, 2020)Objectives: Beta-defensin 1, encoded by the DEFB1 gene, is an important molecule that confers protection from dental caries. Numerous studies have been conducted on the rs11362 polymorphism in the DEFB1 gene. We evaluated ...