Recep Tayyip Erdoğan Üniversitesi Kurumsal Akademik Arşivi
DSpace@RTEÜ, Recep Tayyip Erdoğan Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
The ovoprotective effect of quercetin against methotrexate-induced injury by targeting Nrf2 signalling in female rats
(2026) Demir, Selim; Alemdar, Nihal Türkmen; Livaoglu, Ayten; Yılmaz, Zeynep Sağnak; Demir, Elif Ayazoğlu; Menteşe, Ahmet; Aliyazıcıoğlu, Yüksel
Although methotrexate (MTX) is a widely used anti-cancer drug in chemotherapy, its clinical use is limited due to its toxicity to many organs, including the ovaries. Quercetin (QUE), a natural flavonol, has known antioxidant and anti-inflammatory effects, but QUE's effects on endoplasmic reticulum stress (ERS) and nuclear factor erythroid 2-related factor 2 (Nrf2) pathways in MTX-induced ovotoxicity remain unclear. Therefore, this study was designed to investigate the therapeutic effect of QUE in MTX-exposed rats, including the ERS and Nrf2 signalling pathways. Five groups of six rats were formed as follows: control, MTX (20 mg/kg), MTX+low dose QUE (5 mg/kg), MTX+high dose QUE (10 mg/kg) and only high dose QUE (per se). Colourimetric methods were used to determine the levels of reproductive hormones in serum samples, and markers of oxidative stress (OS), inflammation, ERS, Nrf2 pathway and apoptosis in ovarian tissue. MTX administration resulted in dramatic histopathological findings in ovarian tissue and increased OS, inflammation, ERS and apoptosis associated with Nrf2 inhibition. Conversely, QUE treatment reversed the pathological biochemical and histological changes induced by MTX by modulating the Nrf2 pathway. Taken together, the results of this study provide the first evidences that QUE can ameliorate biochemical and histopathological findings in MTX-induced ovotoxicity. This needs to be supported by more comprehensive mechanistic studies before moving to clinical application.
Energy utilization in aquatic ecosystems: an interdisciplinary approach to sustainable development
(2025) Yılmaz, Boran; Acar, Şükran
An increased focus on the dangers posed by climate change has heightened global interest in the research and development of renewable energy technologies. In other words, the oceans present a vast potential for energy, and investments in this area are rising as renewable energy technologies advance. Studies on ocean thermal energy conversion, offshore wind energy, wave energy, tidal energy, and commercial expansion have resulted in valuable technologies. The potential of these resources contributes to mitigating the risks associated with global climate change; however, it is crucial to safeguard the ocean environment during the development of these technologies. Indeed, if projects are welldefined and appropriately located, and if environmental guidelines are adhered to, the renewable energy resources from the ocean can be harnessed without causing significant harm to the marine ecosystem. This paper aims to explore the existing technologies for renewable energy in the ocean and their current status worldwide.
Determination of the antioxidant activity and antibacterial effect of the α-lipoic acid-NHS molecule in fisheries products
(Ege Üniversitesi, 2025) Kalkan, Samet
Alpha-lipoic acid plays significant roles in metabolic pathways and provides substantial antioxidant defense. In this study, the N-hydroxysuccinimide ester derivative (alpha-lipoic acid-NHS) was examined for antioxidant performance and inhibitory effects on Gram-negative and Gram-positive bacterial strains isolated from aquatic environments. Antioxidant performance was evaluated using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging and CUPRAC (cupric ion reducing) assays. Additionally, The compound's ability to mitigate oxidative stress was evaluated by quantifying reactive oxygen species (ROS) levels with the 8-OHdG ELISA method at different alpha-lipoic acid-NHS concentrations. Antibacterial activity was tested against four reference pathogens (Staphylococcus aureus, Aeromonas hydrophila, Salmonella enterica, Escherichia coli) and four environmental isolates (Bacillus cereus, B. toyonensis, Oceanisphaera sediminis, Pseudomonas putida) using the microdilution method. The results showed that alpha-lipoic acid-NHS exhibited negligible antioxidant activity in both DPPH and CUPRAC assays. In terms of antibacterial effects, however, complete inhibition of growth was observed in some bacterial strains at higher concentrations (5-10 mM). While ROS levels decreased modestly with increasing alpha-lipoic acid-NHS, this effect did not correlate with chemical antioxidant test results, suggesting the reduction was not due to direct antioxidant action. In conclusion, alpha-lipoic acid-NHS does not function as an effective direct radical scavenger but may exert indirect antioxidant effects and moderate antibacterial activity. It may have potential as a supportive compound in antioxidant systems and antibacterial therapies rather than as a standalone therapeutic agent.
Latent role of the islamic responsa (fatwa) in the saudi legal system during the precodification period
(2025) Yakar, Emine Enise; Dindaroğlu, Zehra Betül
The General Presidency of Scholarly Research Ifta) (the Dar al-Ifta)) was established as part of the Saudi government's policies of bureaucratization and institutionalization in 1953. In the absence of a constitutionally binding source of legislation, the Saudi government could consult the Dar al-Ifta) to issue a fatua with the intention of either standardizing a legal ruling or enacting a law. For instance, the fatawa regarding abduction/usurpation and drugs/alcohol were transformed into a legal regulation that considerably facilitated judges' (gadis) application of the prescribed penalties. Before starting the codification process, many social regulations and norms (e.g., the segregation of sexes, women's dress codes, and the legality of forensic autopsies) could also be traced back to the latc7ua issued by the Dar al-Ifta). This article intends to elucidate the complementary role of fatawa in Saudi society as well as the judicial and legislative system by referring to the fatawa transformed by royal decrees into legal regulations before the codification period. This paper provides a detailed analysis of the role of the practice of lila' within the Saudi politico-legal area for the precodification period.
