Browsing by Author "Çiçek, Ayşegül Çopur"
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Antimicrobial resistance patterns and integron carriage of escherichia coli isolates causing community-acquired infections in Turkey
Çiçek, Ayşegül Çopur; Özgümüş, Osman Birol; Saral, Ayşegül; Sandallı, Cemal (Korean Soc Laboratory Medicine, 2014)We aimed to observe antimiCrobial resistance patterns and integron carriage of Escherichia coli isolates causing community-acquired infections. Two hundred sixty-eight E. coli strains were obtained from outpatients with ... -
Antimicrobial susceptibility and molecular characterization of multidrug-resistant acinetobacter baumannii isolated in an university hospital
Direkel, Şahin; Çiçek, Ayşegül Çopur; Karagöz, Alper; Aydoğan Ejder, Nebahat; Oktay, Efdal; Delialioğlu, Nuran; Özgümüş, Osman Birol; Durmaz, Rıza (Ankara Microbiology Soc, 2016)Acinetobacter baumannii, an aerobic, non-motile, gram-negative bacterium is an important nosocomial pathogen which shows resistance to the most antibiotics. Carbapenems are the most commonly used antibiotics for the treatment ... -
Blastoschizomyces capitatus’un neden olduğu üç fungemi olgusu
Koç, A. Nedret; Çiçek, Ayşegül Çopur; Kaynar, Leylagül; Sav, Hafize; Kasap, F. Filiz Tekinşen; Atalay, Mustafa Altay (2013)Blastoschizomyces capitatus özellikle bağışıklık sistemi baskılanmış kişilerde ciddi ve fatal seyreden sistemik enfeksiyonlara neden olabilmektedir. B.capitatus suşlarının hastane enfeksiyonuna neden olduğu ve salgınlar ... -
Carriage of class 1 and 2 integrons in acinetobacter baumannii and pseudomonas aeruginosa isolated from clinical specimens and a novel gene cassette array: bla(OXA-11)-cmlA7
Mengeloğlu, Fırat Zafer; Çiçek, Ayşegül Çopur; Koçoğlu, Esra; Sandallı, Cemal; Budak, Emine Esra; Özgümüş, Osman Birol (Ankara Microbiology Soc, 2014)The dissemination of antibiotic resistance genes between bacteria leads to serious problems in the treatment of infectious diseases. It has been shown that resistance genes can also be carried by the integrons. There are ... -
Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing beta-lactamases in Pseudomonas aeruginosa in Turkey
Iraz, Meryem; Düzgün, Azer Özad; Çiçek, Ayşegül Çopur; Bonnin, Remy A.; Ceylan, Ayşenur; Saral, Ayşegül; Nordmann, Patrice; Sandalli, Cemal (Elsevier Science Inc, 2014)Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), ... -
Clinical potential of resistin as a novel prognostic biomarker for cellulitis
Ertürk, Ayşe; Cüre, Medine Cumhur; Cüre, Erkan; Kurt, Aysel; Çiçek, Ayşegül Çopur; Yüce, Süleyman (Spandidos Publ Ltd, 2015)Cellulitis is an acute, subacute or chronic inflammation of the dermis and subdermal tissues, which is typically caused by bacteria, although other causes are possible. the present study aimed to evaluate the association ... -
Cloning, expression, and characterization of a novel CTP synthase gene from Anoxybacillus gonensis G2
Sandallı, Cemal; Saral, Ayşegül; Ülker, Serdar; Karaoğlu, Hakan; Beldüz, Ali Osman; Çiçek, Ayşegül Çopur (2014)The cytidine-5'-triphosphate (CTP) synthase (EC 6.4.3.2) gene (pyrG) was cloned and sequenced from the thermophilic bacterium Anoxybacillus gonensis G2 (Ago). The gene is 1590 bp in length and encodes a protein of 530 amino ... -
Comparison of standard triple therapy, sequential therapy and moxifloxacin-based triple therapy for Helicobacter pylori infection: Patients' compliance and bacterial eradication rates
Rakıcı, Halil; Akdoğan, Remzi Adnan; Bedir, Recep; Çiçek, Ayşegül Çopur; Yılmaz, Arif (Wiley, 2014)ObjectiveTo compare the patients' compliance with and the efficacy of existing treatments for Helicobacter pylori eradication, including moxifloxacin-based triple therapy, sequential treatment and the standard treatment. ... -
Comparison of verona integron-borne metallo-beta-lactamase (VIM) variants reveals differences in stability and inhibition profiles
Makena, Anne; Düzgün, Azer Özad; Brem, Jurgen; McDonough, Michael A.; Rydzik, Anna M.; Abboud, Martine I.; Saral, Ayşegül; Çiçek, Ayşegül Çopur; Sandallı, Cemal; Schofield, Christopher J. (Amer Soc Microbiology, 2016)Metallo-beta-lactamases (MBLs) are of increasing clinical significance; the development of clinically useful MBL inhibitors is challenged by the rapid evolution of variant MBLs. the Verona integron-borne metallo-beta-lactamase ... -
Crimean-Congo hemorrhagic fever and pregnancy: Two cases
Kırım-Kongo kanamalı ateşi ve gebelik: İki olguKırım-Kongo kanamalı ateşi (KKKA) Hyalomma türü kenelerle, enfekte insanlar ya da evcil hayvanların vücut sıvıları veya dokularıyla doğrudan temas sonucu insanlara bulaşan, ... -
Çeşitli Klinik Örneklerden İzole Edilen Escherichia coli ve Klebsiella Cinsi Bakterilerin Fosfomisin Duyarlılığının Araştırılması
Amaç: Escherichia coli (E. coli) ve Klebsiella cinsi bakteriler geniş spektrumlu beta laktamazları (GSBL) ihtiva etmesi nedeniyle mortalitesi yüksek hastane enfeksiyonlarının en önemli etkenlerindendir. Bu çalışmada E. ... -
Determination of a novel integron-located variant (bla(OXA-320)) of class D beta-lactamase in Proteus mirabilis
Çiçek, Ayşegül Çopur; Düzgün, Azer Özad; Saral, Ayşegül; Sandallı, Cemal (Wiley, 2014)Proteus mirabilis (P. mirabilis) is one of Gram-negative pathogens encountered in clinical specimens. A clinical isolate (TRP41) of P. mirabilis was isolated from a Turkish patient in Turkey. the isolate was identified ... -
Determination of the staphylococcal cassette chromosome in methicillin-resistant Staphylococcus aureus strains isolated from various clinical samples
Çiçek, Ayşegül Çopur; Dinç Patlak, Rukiye; Sandallı, Cemal; Mengeloglu, Zafer; Kostakoğlu, Uğur; Yıldız, İlknur Esen (Science & Innovation, Ltd, 2016)Aim - the present study aimed to detect mecA and staphylococcal cassette chromosome mec (SCCmec) types in methicillin-resistant Staphylococcus aureus (MRSA) isolates obtained from various clinical samples in two university ... -
Distribution of beta-lactamase genes among carbapenem-resistant klebsiella pneumoniae strains isolated from patients in Turkey
Iraz, Meryem; Düzgün, Azer Özad; Sandallı, Cemal; Doymaz, Mehmet Ziya; Akkoyunlu, Yasemin; Saral, Ayşegül; Peleg, Anton Y.; Özgümüş, Osman Birol; Beriş, Fatih Şaban; Karaoğlu, Hakan; Çiçek, Ayşegül Çopur (Korean Soc Laboratory Medicine, 2015)Background: the emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management. We investigated the beta-lactamases in a group of carbapenem-resistant K. pneumoniae clinical isolates ... -
Does prolidase indicate worsening of Hepatitis B infection?
Duygu, Fazilet; Aksoy, Nurten; Çiçek, Ayşegül Çopur; Bütün, İlknur; Ünlü, Şebnem (John Wiley & Sons Inc, 2013)Background Hepatitis B infection is a health problem that affects more than 400 million people all over the world. We aimed to evaluate the usability of prolidase enzyme that plays an important role in collagen synthesis. ... -
Kinetic characterization of GES-22 beta-lactamase harboring the M169L clinical mutation
Saral, Ayşegül; Leonard, David A.; Düzgün, Azer Özad; Çiçek, Ayşegül Çopur; June, Cynthia M.; Sandallı, Cemal (Japan Antibiotics Research Assoc, 2016)The class A p-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a ... -
Klinik örneklerden izole edilen acinetobacter baumannii ve pseudomonas aeruginosa suşlarının sınıf 1 ve 2 integron taşıyıcılığı ve yeni bir gen kaseti birlikteliği: blaOXA-11-cmlA7
Mengeloğlu, Fırat Zafer; Çiçek, Ayşegül Çopur; Koçoğlu, Mücahide Esra; Sandallı, Cemal; Budak, Emine Esra; Özgümüş, Osman Birol (2014)Antibiyotik direnç genlerinin bakteriler arasındaki yayılımı, enfeksiyon hastalıklarının tedavisinde ciddi sorunlar oluşturmaktadır. Son zamanlarda bu genlerin integronlarda da taşındığı gösterilmiştir. Ülkemizde, Acinetobacter ... -
Molecular characterisation and control of Acinetobacter baumannii isolates resistant to multi-drugs emerging in inter-intensive care units
Ertürk, Ayşe; Çiçek, Ayşegül Çopur; Gümüş, Aziz; Cüre, Erkan; Şen, Ahmet; Kurt, Aysel; Karagöz, Alper; Aydoğan, Nebahat; Sandallı, Cemal; Durmaz, Rıza (BmcBMC, 2014)Background: A nosocomial outbreak of Acinetobacter baumannii (AB) infections occurred among intensive care units (ICU) (surgery, medical, cardiovascular surgery, coronary unit) of Recep Tayyip Erdogan University Medical ... -
Molecular epidemiological analysis of integron gene cassettes and tetA/tetB/tetD gene associations in Escherichia coli strains producing extended-spectrum beta-lactamase (ESBL) in urine cultures
Çiçek, Ayşegül Çopur; Şemen, Vicdan; Ejder, Nebahat Aydoğan; Gündoğdu, Deniz Zehra Ulusan; Kalcan, Sema Koçyiğit; Köse, Fatma Tufan; Özgümüş, Osman Birol (Wroclaw Medical University, 2021)Background. Epidemiological studies of tetracycline (TE) resistance genes and integron gene cassettes, particularly in urine samples, are limited in Turkey. Objectives. To investigate antibiotic susceptibility profiles, ... -
A multicenter evaluation of blood culture practices, contamination rates, and the distribution of causative bacteria
Altındiş, Mustafa; Koroğlu, Mehmet; Demiray, Tayfur; Dal, Tuba; Özdemir, Mehmet; Şengil, Ahmet Zeki; Atasoy, Ali Rıza; Doğan, Metin; Çiçek, Ayşegül Çopur; Ece, Gülfem; Kaya, Selçuk; Iraz, Meryem; Gültepe, Bilge Sümbül; Temiz, Hakan; Demirkan, İdris; Aksaray, Sebahat; Çetinkol, Yeliz; Şahin, İdris; Güdücüoğlu, Hüseyin; Kılıç, Abdullah; Koçoğlu, Esra; Gülhan, Barış; Karabay, Oğuz (Ahvaz Jundishapur Univ Med Sci, 2016)Background: the prognostic value of blood culture testing in the diagnosis of bacteremia is limited by contamination. Objectives: in this multicenter study, the aim was to evaluate the contamination rates of blood cultures ...
