Browsing by Author "Tümkaya, Levent"
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Adalimumab ameliorates abdominal aorta cross clamping which induced liver injury in rats
Cüre, Erkan; Cüre, Medine Cumhur; Tümkaya, Levent; Kalkan, Yıldıray; Aydın, İbrahim; Kırbaş, Aynur; Yılmaz, Arif; Yüce, Süleyman; Yücel, Ahmet Fikret (Hindawi Ltd, 2014)The aim of this study was to investigate the possible protective effects of adalimumab (ADA) on cell damage in rat liver tissue during ischemia/reperfusion (I/R) injury of infrarenal abdominal aorta. Thirty male Wistar-albino ... -
Biochemical and histopathological effects on the rat testis after exposure to electromagnetic field during fetal period
Şehitoğlu, İbrahim; Tümkaya, Levent; Kalkan, Yıldıray; Bedir, Recep; Cüre, Medine Cumhur; Zorba, Orhan Ünal; Cüre, Erkan; Yüce, Süleyman (Iniestares, S.A., 2015)OBJECTIVES: Electromagnetic radiation (ER) emitted from cell phones may exert a detrimental influence on human health and may affect the man reproductive system. We aimed to study the biological and morphological effects ... -
Effect of 900-MHz electromagnetic field on the cerebellum: a histopathological investigation
Objectives: The currently widely used technological devices give rise to electromagnetic fields (EMFs) at various frequencies. Recent studies have reported that EMFs damage the central nervous system. The cerebellum is of ... -
The effect of combined hyperbaric oxygen and iloprost treatment on the prevention of spinal cord ischaemia-reperfusion injury: an experimental study (vol 44, e332, 2013) - [Correction]
İlhan, Gökhan; Aksun, Murat; Özpak, Berkan; Güneş, Tevfik; Bozok, Şahin; Durakoğlugil, Murtaza Emre; Tümkaya, Levent; Gürbüz, Ali (Oxford Univ Press Inc, 2014).... -
The effect of exposure of rats during prenatal period to radiation spreading from mobile phones on renal development
Bedir, Recep; Tümkaya, Levent; Şehitoğlu, İbrahim; Kalkan, Yıldıray; Yılmaz, Adnan; Şahin, Osman Zikrullah (Informa Healthcare, 2015)Background: the aim of this study was to investigate the effects of exposure to a 900-MHz electromagnetic field (EMF) produced by mobile phones on the renal development of prenatal rats. Histopathological changes and ... -
The effect of imatinib administered in the prenatal period on testis development in rats
Suzan, Zehra Topal; Tümkaya, Levent; Mercantepe, Tolga; Atak, Muhammed; Uydu, Hüseyin Avni (Sage Publications Ltd, 2021)Background: the purpose of this study was to examine the effects of exposure to imatinib in the prenatal period on testis development in rats. Methods: Although all the study groups received intraperitoneal imatinib on ... -
Effect of infliximab against cisplatin-induced nephrotoxicity
Cüre, Erkan; Kırbaş, Aynur; Tümkaya, Levent; Cüre, Medine Cumhur; Şahin, Osman Zikrullah; Kalkan, Yıldıray; Yüce, Süleyman; Altuner, Durdu (Saudi Med J, 2014)Objectives: To investigate whether infliximab (Ib), an inhibitor of tumor necrosis factor alpha (TNF-alpha), prevents cisplatin (Cis)-induced nephrotoxicity. Methods: the study was performed in the Department of Internal ... -
Effect of infliximab on acute hepatic ischemia/reperfusion injury in rats
Yücel, Ahmet Fikret; Pergel, Ahmet; Aydın, İbrahim; Alaçam, Hasan; Karabıçak, İlhan; Kesicioğlu, Tuğrul; Tümkaya, Levent; Kalkan, Yıldıray; Arslan, Zakir; Şehitoğlu, İbrahim; Şahin, Dursun Ali (E-Century Publishing Corp, 2015)This study aimed to investigate the hepatoprotective and antioxidant effects of infliximab (IFX) against liver ischemia/reperfusion (I/R) injury in rats. A total of 30 male Wistar albino rats were divided into three groups: ... -
Effect of infliximab on renal injury due to methotrexate in rat
Kırbaş, Aynur; Cüre, Medine Cumhur; Kalkan, Yıldıray; Cüre, Erkan; Tümkaya, Levent; Şahin, Osman Zikrullah; Yüce, Süleyman; Kızılkaya, Bayram; Pergel, Ahmet (Iranian Soc Nephrolgy, 2015)Introduction. Methotrexate, an antagonist of folic acid used in the treatment of many cancers and inflammatory diseases, is associated with side effects that limit its usage. Infliximab has been reported to have a protective ... -
The effect of prenatal exposure to 1800 MHz electromagnetic field on calcineurin and bone development in rats
Erkut, Adem; Tümkaya, Levent; Balık, Mehmet Sabri; Kalkan, Yıldıray; Güvercin, Yılmaz; Yılmaz, Adnan; Yüce, Süleyman; Cüre, Erkan; Şehitoğlu, İbrahim (Acta Cirurgica Brasileira, 2016)PURPOSE: To investigated the effects of exposure to an 1800 MHz electromagnetic field (EMF) on bone development during the prenatal period in rats. METHODS: Pregnant rats in the experimental group were exposed to radiation ... -
Effect of sugammadex on rocuronium induced changes in pancreatic mast cells
Kalkan, Yıldıray; Tümkaya, Levent; Bostan, Habib; Tomak, Yakup; Altuner, Durdu; Yılmaz, Adnan; Erdivanlı, Başar; Bedir, Recep; Yalçın, Alper; Turan, Alparslan (Sage Publications Inc, 2015)Mast cells play a vital role in hypersensitivity reactions. Rocuronium is known to cause mast cell mobilization, hypersensitivity, and pancreatitis. the aim of this study was to investigate the effects of sugammadex on ... -
Effects of chronic exposure to electromagnetic waves on the auditory system
Özgür, Abdulkadir; Tümkaya, Levent; Terzi, Suat; Kalkan, Yıldıray; Erdivanlı, Özlem Çelebi; Dursun, Engin (Taylor & Francis Ltd, 2015)Conclusion: the results support that chronic electromagnetic field exposure may cause damage by leading to neuronal degeneration of the auditory system. Objectives: Numerous researches have been done about the risks of ... -
The effects of infliximab on laminin, NF kappa B, and Anti-TNF expression through Its effect on ischemic liver tissue
Akdoğan, Remzi Adnan; Kalkan, Yıldıray; Tümkaya, Levent; Rakıcı, Halil; Akdoğan, Elif (Hindawi Ltd, 2016)The aim of this study was to investigate the possible protective effects of infliximab on expression of laminin, anti-TNF, and NF kappa B in the rat hepatic cells after ischemia/reperfusion (I/R). A total of 30 male Wistar ... -
The effects of whortleberry on ischemia reperfusion-induced myocardial injury in rats
Karakişi, Sedat Ozan; Hemşinli, Doğuş; Ergene, Şaban; Mercantepe, Tolga; Tümkaya, Levent; Yılmaz, Adnan (2020)Background: The aim of this study was to investigate the potential protective effect of whortleberry by examining the effects on heart tissue at the molecular level of ischemia-reperfusion injury caused by surgical repair ... -
Gene expression and histopathological evaluation of thiamine pyrophosphate on optic neuropathy induced with ethambutol in rats
Çinici, Emile; Çetin, Nihal; Süleyman, Bahadır; Altuner, Durdu; Yaralı, Oğuzhan; Balta, Hilal; Çalık, İlknur; Tümkaya, Levent; Süleyman, Halis (Ijo Press, 2016)AIM: To compare the effects of thiamine pyrophosphate (TPP) and thiamine (TM) in oxidative optic neuropathy in rats induced by ethambutol. METHODS: the animals were divided into four groups: a control group (CG), an ... -
Infliximab modulates cisplatin-induced hepatotoxicity in rats
Cüre, Medine Cumhur; Cüre, Erkan; Kalkan, Yıldıray; Kırbaş, Aynur; Tümkaya, Levent; Yılmaz, Arif; Türkyılmaz, Ayşegül Küçükali; Sehitoğlu, İbrahim; Yüce, Süleyman (Galenos Publ, 2016)Background: Cisplatin (Cis) is one of the most com-monly used antineoplastic drugs. It is used as chemo-therapy for many solid organ malignancies such as brain, neck, male and female urogenital, vesical and pulmonary ... -
Influence of infliximab pretreatment on ischemia/reperfusion injury in rat intestine
Akdoğan, Remzi Adnan; Kalkan, Yıldıray; Tümkaya, Levent; Alacam, Hasan; Erdivanlı, Başar; Aydın, İbrahim (Via Medica, 2014)The Pringle maneuver is used in hepatic surgery to prevent blood loss but is associated with ischemia-reperfusion injury. To investigate the effect of infliximab on inflammation and apoptosis in rat intestinal mucosa during ... -
Is resveratrol a potential substitute for leuprolide acetate in experimental endometriosis?
Tekin, Yeşim Bayoğlu; Güven, Süleyman; Kırbaş, Aynur; Kalkan, Yıldıray; Tümkaya, Levent; Güven, Emine Seda Güvendağ (Elsevier Science Bv, 2015)Objective: Resveratrol, a phytoalexin polyphenol, has anti-angiogenic, antioxidant, anti-inflammatory properties. We aimed to compare the anti-inflammatory and anti-angiogenic effects of resveratrol and leuprolide acetate ... -
Less Use of the Bipolar Cautery can Prevent Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats
AIM: To investigate the role of bipolar electrocautery in the occurrence of epidural fibrosis following lumbar spine laminectomy in a rat model. MATERIAL and METHODS: Fourteen male Sprague–Dawley rats (age: 4–6 months, ...
