Browsing by Author "Tümkaya, Levent"
Now showing items 1-20 of 165
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Adalimumab ameliorates abdominal aorta cross clamping which induced liver injury in rats
Cüre, Erkan; Cüre, Medine Cumhur; Tümkaya, Levent; Kalkan, Yıldıray; Aydın, İbrahim; Kırbaş, Aynur; Yılmaz, Arif; Yüce, Süleyman; Yücel, Ahmet Fikret (Hindawi Ltd, 2014)The aim of this study was to investigate the possible protective effects of adalimumab (ADA) on cell damage in rat liver tissue during ischemia/reperfusion (I/R) injury of infrarenal abdominal aorta. Thirty male Wistar-albino ... -
Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus
Saral, Sinan; Topçu, Atilla; Alkanat, Mehmet; Mercantepe, Tolga; Şahin, Zafer; Akyıldız, Kerimali; Karataş, Kader Semra; Yıldız, Lamiye; Tümkaya, Levent; Yazıcı, Zihni Açar (Elsevier, 2023)Cisplatin is a drug used effectively in the treatment of malignant tumors. However, cisplatin has many side ef-fects, including cognitive impairment. Agomelatine, a synthetic melatonin analogue, is an important antide-pressant. ... -
Agomelatine on cisplatin-induced nephrotoxicity via oxidative stress and apoptosis
Dil, Eyüp; Topçu, Atilla; Mercantepe, Tolga; Tümkaya, Levent; Akyıldız, Kerimali; Saral, Sinan; Yılmaz, Adnan (Springer, 2023)Drug-induced nephrotoxicity is the greatest deterrent to the use of cisplatin, which is a frequently used chemotherapeutic with proven efectiveness in cancer therapy. Agomelatine, which is used in the treatment of sleep ... -
Apelin-13 activates the hippocampal BDNF/TrkB signaling pathway and suppresses neuroinflammation in male rats with cisplatin-induced cognitive dysfunction
Saral, Sinan; Topçu, Atilla; Alkanat, Mehmet; Mercantepe, Tolga; Akyıldız, Kerimali; Yıldız, Lamiye; Tümkaya, Levent; Yazıcı, Zihni Açar; Yılmaz, Adnan (Elsevier, 2021)It has been established that cisplatin causes neuronal damage and cognitive impairment. However, the mechanism is not sufficiently clear. Apelin-13 is an endogenous peptide with strong neuroprotective effects through the ... -
Biochemical and histopathological effects on the rat testis after exposure to electromagnetic field during fetal period
Şehitoğlu, İbrahim; Tümkaya, Levent; Kalkan, Yıldıray; Bedir, Recep; Cüre, Medine Cumhur; Zorba, Orhan Ünal; Cüre, Erkan; Yüce, Süleyman (Iniestares, S.A., 2015)OBJECTIVES: Electromagnetic radiation (ER) emitted from cell phones may exert a detrimental influence on human health and may affect the man reproductive system. We aimed to study the biological and morphological effects ... -
Can dexmedetomidine be effective in the protection of radiotherapy-induced brain damage in the rat?
Çınar, Seda; Tümkaya, Levent; Mercantepe, Tolga; Saral, Sinan; Rakıcı, Sema; Yılmaz, Adnan; Topçu, Atilla; Şen, Ahmet; Karakaş, Sibel (Springer, 2021)Approximately 7 million people are reported to be undergoing radiotherapy (RT) at any one time in the world. However, it is still not possible to prevent damage to secondary organs that are off-target. This study, therefore, ... -
The cardioprotective effects of perindopril in a model of polymicrobial sepsis: The role of radical oxygen species and the inflammation pathway
Topçu, Atilla; Kostakoğlu, Uğur; Mercantepe, Tolga; Yılmaz, Hülya K.; Tümkaya, Levent; Uydu, Hüseyin Avni (Wiley, 2022)Mortality rates associated with myocardial dysfunction due to sepsis and septic shock are generally high across the world. The present study focused on the antioxidant and anti-inflammatory effects of perindopril (PER) for ... -
Chitosan-coated scorpion venom ameliorates acute lung injury caused by klebsiella pneumoniae
Oskay, Burak; Şahin, Kazım; Çalışkan, Figen; Mercantepe, Tolga; Aktura, Sena Şahin; Tümkaya, Levent; Topçu, Atilla; Yılmaz, Adnan; Karakaş, Sibel Mataracı; Yazıcı, Zihni Açar (Springer, 2024)Nosocomial infections caused by antibiotic-resistant bacteria result in significant economic costs and human health issues, including acute lung injury. The purpose of this study was to investigate the scorpion venom in ... -
Circadian clock on ionizing radiation-induced testicular injury
Çiftel, Serpil; Mercantepe, Filiz; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema Yılmaz; Çiftel, Enver (AVES, 2024)Objective: This research focuses on the interaction between the circadian clock and the damage caused to testicular tissue by x-ray ionizing radiation. By examining the links between circadian rhythms and radiation -induced ... -
Clinical and histologic evaluation of partial achilles tendon ınjury repair with amniotic membrane in rats
Background: Adhesions after tendinopathy in individuals who perform physical work and those physically active in middle age are a challenging problem for orthopedic surgeons. We evaluated the effects of human-derivated ... -
Comparison of DNA isolation methods from mammalian sperm cells and development of a new protocol
Nalkıran, Hatice Sevim; Nalkıran, İhsan; Rakıcı, Sema Yılmaz; Tümkaya, Levent; Güzel, Ali İrfan (Effect Publishing Agency ( EPA ), 2021)Sperm DNA tightly packed with protamines makes the DNA isolation procedure from sperm cells long and laborious. Cell lysis is also a challenging step because of the disulfide bonds-rich membranes of the sperm cells. In ... -
Comparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage
Şafak, Gökhan; Çeliker, Metin; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema; Çınar, Seda; Yılmaz, Adnan; Terzi, Suat; Demir, Emine; Erdivanlı, Özlem Çelebi; Coşkun, Zerrin Özergin; Karakaş, Sibel; Birinci, Mehmet; Dursun, Engin (Springer, 2022)Radiotherapy can be employed as a therapeutic modality alone in the early stages of cancer and is used together with other treatments such as surgery and chemotherapy in more advanced stages. However, exposure to ionizing ... -
Comparison of linear versus macrocyclic gadolinium chelates in rat skeletal muscle
Balık, Mehmet Sabri; Çeliker, Fatma Beyazal; Tümkaya, Levent; Mercantepe, Tolga; Topçu, Atilla; Şahin, Rıfat; Balık, Gülşah (2022)OBJECTIVE: We investigated the effects on skeletal muscle of gadolinium based linear and macrocyclic radiocontrast agents applied at experimental intervals using histopathological methods. METHODS: Thirty-two male ... -
Cystic schwannoma of the right brachial plexus causing thoracic outlet syndrome
Sönmez, Osman Fikret; Tümkaya, Levent; Kanat, Ayhan; Demir, Zafer; Baş, Orhan (Ondokuz Mayıs University, 2012)A rare case of a schwannoma of the right brachial plexus presenting with a cystic lesion is presented here. A 36-year-old man was admitted to our department with numbness, pain and progressive, lingering paralysis in the ... -
Dexamethasone and concentrated growth factors on peripheral nerve injury: A clinic-relevant animal study
Kalyoncu, Alperen; Balaban, Emre; Mercantepe, Tolga; Tümkaya, Levent (Elsevier, 2024)Background: Mandibular nerve injury is a common clinical condition that affects clinicians’ management and patients’ quality of life. In the literature, there are various effective treatments available. The primary purpose ... -
Dexmedetomidine alleviates vacuolization and necrosis in tubular epithelial cells induced by aortic cross-clamping
Ergene, Şaban; Hemşinli, Doğuş; Karakişi, Sedat Ozan; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan (Verduci Publisher, 2023)OBJECTIVE: Acute kidney inju-ry (AKI) is one of the main causes of mortality in patients undergoing emergency surgery due to an abdominal aortic aneurysm. This study aimed to determine the potential nephroprotec-tive ... -
Dexmedetomidine attenuates pneumocyte apoptosis and inflammation induced by aortic ischemia-reperfusion injury
Hemşinli, Doğuş; Tümkaya, Levent; Ergene, Şaban; Karakişi, Sedat Ozan; Mercantepe, Tolga; Yılmaz, Adnan (Taylor & Francis Ltd., 2022)Objective Despite significant improvements in interventional vascular aneurysm repair procedures and intensive care patient management, there has been no significant decrease in mortality due to ruptured abdominal aortic ... -
Does radiofrequency radiation from mobile phones affect the formation of parotid gland malignancy? An experimental study
Özergin Coşkun, Zerrin; Tümkaya, Levent; Yılmaz, Adnan; Dursun, Engin; Mercantepe, Tolga; Kalkan, Yıldıray; Ersöz, Şafak (Sage Publications, 2024)Objectives: The use of mobile phone is increasing around the world. Although it is beneficial in terms of communication, the electromagnetic radiations emitted by mobile phones may cause undesirable biological effects on ... -
Effect of 900-MHz electromagnetic field on the cerebellum: a histopathological investigation
Objectives: The currently widely used technological devices give rise to electromagnetic fields (EMFs) at various frequencies. Recent studies have reported that EMFs damage the central nervous system. The cerebellum is of ...
