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Toplam kayıt 32, listelenen: 1-10
Protective role of whortleberry extract against cisplatin induced ototoxicity in rats
(Recep Tayyip Erdoğan Üniversitesi / Tıp Fakültesi / Kulak Burun Boğaz Anabilim Dalı, 2016)
Giriş/amaç:Cisplatin, baş boyun kanserlerinde sıklıkla kullanılan bir kemoteropötik olmasına rağmen gelişebilen ototoksik etkisi halen ciddi bir sorundur. Bu ototoksisiteden korunmak ve/veya önlemek amacıyla literatürde ...
Ratlarda Cisplatinin Oluşturduğu Karaciğer Hasarında Beyaz Çayın Etkisi
(Recep Tayyip Erdoğan Üniversitesi, Sağlık Bilimleri Enstitüsü, Tıbbi Biyokimya Anabilim Dalı, 2019)
Abstract: The aim of this study was to investigate the reduction or elimination of cisplatin-induced liver damage in chronic white tea-fed rats. For this purpose, 24 female Sprague Dawley rats from 3 groups of 8 were used. ...
Infliximab modulates cisplatin-induced hepatotoxicity in rats
(Galenos Publ, 2016)
Background: Cisplatin (Cis) is one of the most com-monly used antineoplastic drugs. It is used as chemo-therapy for many solid organ malignancies such as brain, neck, male and female urogenital, vesical and pulmonary ...
The protective effect of melatonin and agomelatin against cisplatin-induced nephrotoxicity and oxidative stress in the rat kidney
(Colegio Farmaceuticos Provincia de Buenos Aires, 2013)
Cisplatin is used to treat various types of cancers. Its use is limited, however, due to nephrotoxicity, which may result from free radical damage. Evidence exists that melatonin reduces oxidative stress-induced damage. ...
Protective effect of mirtazapine against cisplatin-induced oxidative stress and DNA damage in guinea pig ear
(Scientific Publishers India, 2014)
Cisplatin ototoxicity is a major dose-limiting factor in the treatment of several neoplastic diseases. Oxidative stress might play an important role of pathogenesis of cisplatin ototoxicity. the aim of this study was to ...
The protective effect of infliximab on cisplatin-induced intestinal tissue toxicity
(Verduci Publisher, 2014)
OBJECTIVE: Cisplatin (CP) is a popular chemotherapeutic agent. However, high doses of CP may lead to severe side effects to the gastrointestinal system. the aim of this study was to investigate the protective effects of ...
The role of antioxidant activity in the prevention and treatment of infertility caused by cisplatin in rats
(Karger, 2015)
Background/Aims:To investigate the importance of antioxidant activity in infertility caused by cisplatin in rats. Methods: Rats in cisplatin control (CG), Vitamin E+cisplatin (ECG), Vitamin C + cisplatin (CCG), Hippophae ...
Anticancer effects of a novel herbal combination as a potential therapeutic candidate against lung cancer
(Elsevier Science, 2021)
Introduction: Cancer continues to be a prevalent health problem with increasing mortality rates. The interest in complementary medicine for cancer treatment has increased in recent years. In this study, we aimed to investigate ...
Apelin-13 activates the hippocampal BDNF/TrkB signaling pathway and suppresses neuroinflammation in male rats with cisplatin-induced cognitive dysfunction
(Elsevier, 2021)
It has been established that cisplatin causes neuronal damage and cognitive impairment. However, the mechanism is not sufficiently clear. Apelin-13 is an endogenous peptide with strong neuroprotective effects through the ...
The effects of apelin-13 against cisplatin-induced nephrotoxicity in rats
(Taylo & Francis Ltd., 2021)
Acute kidney injury (AKI) is observed in nearly 60% of patients undergoing cisplatin (CP) therapy. The aim of this study was to reveal the potential effects of apelin-13 (AP-13) in the prevention of CP-induced renal toxicity, ...