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Küçük Resim

The protective effects of perindopril against acute kidney damage caused by septic shock 

Kostakoğlu, Uğur; Mercantepe, Tolga; Yılmaz, Hülya Kılıç; Tümkaya, Levent; Batçık, Şule; Pınarbaş, Esra; Uydu, Hüseyin Avni (Springer/Plenum Publishers, 2021)
Acute kidney injury (AKI) resulting from septic shock caused by sepsis is an important health problem encountered at rates of 55-73%. Increasing oxidative stress and inflammation following sepsis is a widely observed ...
Küçük Resim

The protective role of fosfomycin in lung injury due to oxidative stress and inflammation caused by sepsis 

Yıldız, İlknur Esen; Topçu, Atilla; Bahçeci, İlkay; Arpa, Medeni; Tümkaya, Levent; Mercantepe, Tolga; Batçık, Şule; Yıldız, Yasin (Pergamon-Elsevier Science Ltd., 2021)
Aim: Early and prompt treatment of sepsis by effective antibiotics against susceptible organisms may be lifesaving. However, increased antibiotic resistance and side effects of chemotherapeutic agents limiting their ...
Küçük Resim

Effects of gadolinium-based MRI contrast agents on liver tissue 

Mercantepe, Tolga; Tümkaya, Levent; Çeliker, Fatma Beyazal; Suzan, Zehra Topal; Çınar, Seda; Akyıldız, Kerimali; Mercantepe, Filiz; Yılmaz, Adnan (Wiley, 2018)
BackgroundPurposeMRI with contrast is often used clinically. However, recent studies have reported a high accumulation of gadolinium-based contrast agents (GBCAs) in kidney, liver, and spleen tissues in several mouse models. ...
Küçük Resim

An investigation of the effects of metformin on ovarian ischemia-reperfusion injury in rats 

Topçu, Atilla; Balık, Gülşah; Atak, Mehtap; Mercantepe, Tolga; Uydu, Hüseyin Avni; Tümkaya, Levent (Elsevier, 2019)
Damage to the ovaries or tissue torsion can significantly reduce the ovarian reserve and thus cause severe gynecological and hormonal deficiencies. the discovery of new agents is always needed in the treatment of this ...
Küçük Resim

The radioprotective effect of N-acetylcysteine against x-radiation-induced renal injury in rats 

Mercantepe, Tolga; Topçu, Atilla; Rakıcı, Sema; Tümkaya, Levent; Yılmaz, Adnan; Mercantepe, Filiz (Springer Heidelberg, 2019)
The purpose of this study was therefore to investigate the effects of radiotherapy on the kidney and the potential use of agents such as N-acetylcysteine (NAC) in developing a future therapeutic protocol for radiation-induced ...
Küçük Resim

An investigation of the effects of N-acetylcysteine on radiotherapy-induced testicular injury in rats 

Topçu, Atilla; Mercantepe, Filiz; Rakıcı, Sema; Tümkaya, Levent; Uydu, Hüseyin Avni; Mercantepe, Tolga (Springer, 2019)
According to data issued by the International Agency for Research on Cancer in 2012, the estimated number of new cases of all types of cancer worldwide was estimated to exceed 10 million, and 6 million of whom receive ...
Küçük Resim

The protective effects of angiotensin-converting enzyme inhibitor against cecal ligation and puncture-induced sepsis via oxidative stress and inflammation 

Kostakoğlu, Uğur; Topçu, Atilla; Atak, Mehtap; Tümkaya, Levent; Mercantepe, Tolga; Uydu, Hüseyin Avni (Pergamon-Elsevier Science Ltd, 2020)
Aims: Sepsis is a severe public health problem affecting millions of individuals, with global mortality rates caused by lower respiratory tract infections are approximately 2.38 million people a year die from respiratory ...
Küçük Resim

Protective effects of nebivolol on ovarian ischemia-reperfusion injury in rat 

Çolak, Sabri; Gürlek, Beril; Topçu, Atilla; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan (Wiley, 2020)
Aim Ovarian torsion is a common gynecological emergency of reproductive ages, occurring at rates of 2.7-7.4%. This study aimed to evaluate the antioxidant effects of Nebivolol (NEB) and histopathological changes in ...
Küçük Resim

The protective effects of adalimumab on intestinal injury induced with infrarenal aortic occlusion 

Pergel, Ahmet; Tümkaya, Levent; Demiral, Gökhan; Çolakoğlu, Muhammet Kadri; Kalcan, Süleyman; Özdemir, Ali; Mercantepe, Tolga; Erdivanlı, Başar; Yılmaz, Adnan (Turkish Assoc Trauma Emergency Surgery, 2020)
BACKGROUND: the present study aims to observe the effects of ischemia-reperfusion (IR) on small intestines at a molecular level and to prospectively assess the potential preventive role of adalimumab (ADA) and antioxidants. ...
Küçük Resim

The effects of dexmedetomidine on early acute kidney injury in severely burned rats 

Özdemir, Ayşe; Topçu, Atilla; Mercantepe, Tolga; Arpa, Medeni; Karakaş, Sibel Mataracı; Özdemir, Ali Sezin; Tümkaya, Levent; Mercantepe, Filiz (Verduci Publisher, 2023)
OBJECTIVE: Burns are a global medical and economic problem. In addition to high costs, the lengthy therapeutic process and the emotional trauma experienced by patients and their families indirectly worsen the socioeconomic ...
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Mercantepe, Tolga (12)
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