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The protective effects of adalimumab on intestinal injury induced with infrarenal aortic occlusion

Access

info:eu-repo/semantics/closedAccess

Date

2020

Author

Pergel, Ahmet
Tumkaya, Levent
Demiral, Gokhan
Colakoglu, Muhammet Kadri
Kalcan, Suleyman
Ozdemir, Ali
Yilmaz, Adnan

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Abstract

BACKGROUND: the present study aims to observe the effects of ischemia-reperfusion (IR) on small intestines at a molecular level and to prospectively assess the potential preventive role of adalimumab (ADA) and antioxidants. METHODS: A total of 24 male Sprague-Dawley rats were randomly divided into three groups-a control group, an IR group and an IR+ADA group. RESULTS: Although there was no change in SOD levels in the small bowel tissue of the IR group, we observed increased malondialdehyde (MDA) levels and increased numerical density of caspase-3 and TNF-alpha positive enterocytes p=0.00 and p=0.00, respectively). We also observed that IR caused the degeneration of villus crypt structures. CONCLUSION: We found that ADA treatment reduced MDA levels and decreased the numerical density of caspase-3 and TNF-a positive enterocytes compared to the IR group (p=0.00; p=0.011; p=0.00, respectively). We conclude that ADA can be beneficial in preventing intestinal injury that arises from IR.

Source

Ulusal Travma ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery

Volume

26

Issue

3

URI

https://doi.org/10.14744/tjtes.2019.59607
https://hdl.handle.net/11436/1152

Collections

  • PubMed İndeksli Yayınlar Koleksiyonu [1045]
  • Scopus İndeksli Yayınlar Koleksiyonu [3485]
  • WoS İndeksli Yayınlar Koleksiyonu [2846]



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