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Küçük Resim

Apelin-13 activates the hippocampal BDNF/TrkB signaling pathway and suppresses neuroinflammation in male rats with cisplatin-induced cognitive dysfunction 

Saral, Sinan; Topçu, Atilla; Alkanat, Mehmet; Mercantepe, Tolga; Akyıldız, Kerimali; Yıldız, Lamiye; Tümkaya, Levent; Yazıcı, Zihni Açar; Yılmaz, Adnan (Elsevier, 2021)
It has been established that cisplatin causes neuronal damage and cognitive impairment. However, the mechanism is not sufficiently clear. Apelin-13 is an endogenous peptide with strong neuroprotective effects through the ...
Küçük Resim

The effects of apelin-13 against cisplatin-induced nephrotoxicity in rats 

Topçu, Atilla; Saral, Sinan; Mercantepe, Tolga; Akyıldız, Kerimali; Tümkaya, Levent; Yılmaz, Adnan (Taylo & Francis Ltd., 2021)
Acute kidney injury (AKI) is observed in nearly 60% of patients undergoing cisplatin (CP) therapy. The aim of this study was to reveal the potential effects of apelin-13 (AP-13) in the prevention of CP-induced renal toxicity, ...
Küçük Resim

The protective effect of astaxanthin on cisplatin-induced ototoxicity 

Terzi, Suat; Özgür, Abdulkadir; Çeliker, Metin; Mercantepe, Tolga; Yılmaz, Adnan; Tümkaya, Levent; Kaya, Şeyma; Demir, Emine; Dursun, Engin (Wroclaw Medical Univercity, 2021)
Background. Promising studies have been conducted with many substances to reduce the ototoxic effects of cisplatin, but there is no treatment that completely eliminates the ototoxic effect. Objectives. To determine the ...
Küçük Resim

Protective effects of amifostine, curcumin, and melatonin against cisplatin-induced acute kidney injury 

Mercantepe, Filiz; Mercantepe, Tolga; Topçu, Atilla; Yılmaz, Adnan; Tümkaya, Levent (Springer, 2018)
Despite the enormous advances made in the field of oncology, no solution to the side effect of nephrotoxicity caused by cisplatin used as an antineoplastic agent for approximately 40 years has yet been discovered. This ...
Küçük Resim

Protective effects of amifostine, curcumin and caffeic acid phenethyl ester against cisplatin-induced testis tissue damage in rats 

Mercantepe, Tolga; Ünal, Deniz; Tümkaya, Levent; Yazıcı, Zihni Açar (Spandidos Publ Ltd, 2018)
Cisplatin is an effective antineoplastic drug that is usually used to treat a number of different types of cancer in the clinic. One of the most notable side effects of cisplatin use is infertility. the present study was ...
Küçük Resim

Protective effect of tea grape extract on cisplatin-induced muscle atrophy: A morphological study 

Balık, Mehmet Sabri; Tümkaya, Levent; Mercantepe, Tolga; Yılmaz, Adnan; Balık, Gülşah; Topçu, Atilla; Yazıcı, Zihni Açar (Kowsar Publ, 2018)
Background: Even though Cisplatin (Cis) is known to be organotoxic, it is used in neoplastic chemotherapy. in skeletal muscles, the toxic effect manifests as atrophy. Objectives: the tea grape extract (TGE) is a sort of ...
Küçük Resim

The protective effect of astaxanthin against cisplatin-induced nephrotoxicity in rats 

Akça, Görkem; Eren, Hüseyin; Tümkaya, Levent; Mercantepe, Tolga; Horsanali, Mustafa Ozan; Deveci, Ezgi; Yılmaz, Adnan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)
Purpose: the aim of this experimental study was to investigate the antioxidant effects of astaxanthin against cisplatin-induced nephrotoxicity in rats. Methods: Forty-eight male Sprague-Dawley rats weighing 264.83 +/- 7.39 ...
Küçük Resim

The effect of white tea on serum TNF-alpha/NF-kappa B and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats 

Saral, Sinan; Dokumacıoğlu, Eda; Mercantepe, Tolga; Atak, Mehtap; Çınar, Seda; Saral, Özlem; Yıldız, Lamiye; İskender, Hatice; Tümkaya, Levent (Elsevier France-Editions Scientifiques Medicales Elsevier, 2019)
Objective: Nephrotoxicity is the most important side effect of the antineoplastic drug cisplatin, thereby restricting its use. the aim of this study was to investigate the protective effects of white tea infusions(WT) ...
Küçük Resim

Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus 

Saral, Sinan; Topçu, Atilla; Alkanat, Mehmet; Mercantepe, Tolga; Şahin, Zafer; Akyıldız, Kerimali; Karataş, Kader Semra; Yıldız, Lamiye; Tümkaya, Levent; Yazıcı, Zihni Açar (Elsevier, 2023)
Cisplatin is a drug used effectively in the treatment of malignant tumors. However, cisplatin has many side ef-fects, including cognitive impairment. Agomelatine, a synthetic melatonin analogue, is an important antide-pressant. ...
Küçük Resim

Agomelatine on cisplatin-induced nephrotoxicity via oxidative stress and apoptosis 

Dil, Eyüp; Topçu, Atilla; Mercantepe, Tolga; Tümkaya, Levent; Akyıldız, Kerimali; Saral, Sinan; Yılmaz, Adnan (Springer, 2023)
Drug-induced nephrotoxicity is the greatest deterrent to the use of cisplatin, which is a frequently used chemotherapeutic with proven efectiveness in cancer therapy. Agomelatine, which is used in the treatment of sleep ...
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Mercantepe, Tolga (14)
Tümkaya, Levent (12)Yılmaz, Adnan (10)Topçu, Atilla (7)Akyıldız, Kerimali (6)Saral, Sinan (5)Yazıcı, Zihni Açar (4)Yıldız, Lamiye (3)Alkanat, Mehmet (2)Atak, Mehtap (2)... Daha FazlaAnahtar Kelime
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Rat (4)Nephrotoxicity (3)Oxidative stress (3)Agomelatine (2)Amifostine (2)Apelin-13 (2)Astaxanthin (2)BDNF (2)Caspase-3 (2)... Daha FazlaYayın Tarihi2018 (4)2021 (3)2023 (3)2024 (3)2019 (1)Mevcut Dosya(lar)Tam Metni Olanlar (14)

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