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Küçük Resim

The protective effects of perindopril against acute kidney damage caused by septic shock 

Kostakoğlu, Uğur; Mercantepe, Tolga; Yılmaz, Hülya Kılıç; Tümkaya, Levent; Batçık, Şule; Pınarbaş, Esra; Uydu, Hüseyin Avni (Springer/Plenum Publishers, 2021)
Acute kidney injury (AKI) resulting from septic shock caused by sepsis is an important health problem encountered at rates of 55-73%. Increasing oxidative stress and inflammation following sepsis is a widely observed ...
Küçük Resim

The effect of imatinib administered in the prenatal period on testis development in rats 

Suzan, Zehra Topal; Tümkaya, Levent; Mercantepe, Tolga; Atak, Muhammed; Uydu, Hüseyin Avni (Sage Publications Ltd, 2021)
Background: the purpose of this study was to examine the effects of exposure to imatinib in the prenatal period on testis development in rats. Methods: Although all the study groups received intraperitoneal imatinib on ...
Küçük Resim

The protective role of fosfomycin in lung injury due to oxidative stress and inflammation caused by sepsis 

Yıldız, İlknur Esen; Topçu, Atilla; Bahçeci, İlkay; Arpa, Medeni; Tümkaya, Levent; Mercantepe, Tolga; Batçık, Şule; Yıldız, Yasin (Pergamon-Elsevier Science Ltd., 2021)
Aim: Early and prompt treatment of sepsis by effective antibiotics against susceptible organisms may be lifesaving. However, increased antibiotic resistance and side effects of chemotherapeutic agents limiting their ...
Küçük Resim

Protective effect of thymoquinone in preventing trauma-related damage: an experimental study 

Erdivanlı, Başar; Özdemir, Abdullah; Şen, Ahmet; Mercantepe, Tolga; Kazdal, Hızır; Uydu, Hüseyin Avni; Tümkaya, Levent (Taylo & Francis Ltd., 2021)
Background Secondary injury is a potentially modifiable factor of outcome in traumatic brain injury. This study aimed to investigate thymoquinone's effects on trauma-induced neuronal damage. Methods Eighteen adult female ...
Küçük Resim

Can dexmedetomidine be effective in the protection of radiotherapy-induced brain damage in the rat? 

Çınar, Seda; Tümkaya, Levent; Mercantepe, Tolga; Saral, Sinan; Rakıcı, Sema; Yılmaz, Adnan; Topçu, Atilla; Şen, Ahmet; Karakaş, Sibel (Springer, 2021)
Approximately 7 million people are reported to be undergoing radiotherapy (RT) at any one time in the world. However, it is still not possible to prevent damage to secondary organs that are off-target. This study, therefore, ...
Küçük Resim

Effects of gadodiamide and gadoteric acid on lung tissue: A comparative study 

Çeliker, Fatma Beyazal; Tümkaya, Levent; Suzan, Zehra T.; Topçu, Atilla; Mercantepe, Tolga; Çınar, Seda; Yazıcı, Zihni Açar; Yılmaz, Adnan (Wiley, 2022)
We set out to investigate the effects of gadodiamide and gadoteric acid, used for magnetic resonance imaging, on the lungs. In this study, 32 male Sprague Dawley rats were used. These were allocated into four groups; The ...
Küçük Resim

Effect of the prenatal electromagnetic field exposure on cochlear nucleus neurons and oligodendrocytes in rats 

Tümkaya, Levent; Baş, Orhan; Mercantepe, Tolga; Çınar, Seda; Özgür, Abdulkadir; Yazıcı, Zihni Açar (Springer Heidelberg, 2022)
Electromagnetic radiation from elecromagnetic field (EMF) sources has been an important health concern for a long time. The vast majority of this exposure is due to the widespread use of mobile phones, an important source ...
Küçük Resim

Histopathological evaluation of the effects of dexmedetomidine against pituitary damage ınduced by X-ray irradiation 

Mercantepe, Filiz; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema (Taylor & Francis Ltd., 2022)
Background: The present study, aimed to investigate the potential negative effects of x-ray radiation and the effects of the α2-adrenergic receptor agonist dexmedetomidine on the pituitary gland. Methods: Twenty-four ...
Küçük Resim

Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity 

Mercantepe, Tolga; Kalkan, Yıldıray; Tümkaya, Levent; Şehitoğlu, İbrahim; Mercantepe, Filiz; Yıldırmış, Sermet (Wroclaw Medical Univ, 2018)
Background. Methotrexate (MTX), a folate antagonist, is commonly used in the treatment of many different types of cancer and inflammatory diseases, including pancreatic cancer, although its side effects on the pancreas ...
Küçük Resim

Effects of gadolinium-based contrast agents on submandibular gland tissue in rats 

Çeliker, Fatma Beyazal; Tümkaya, Levent; Yılmaz, Adnan; Coşkun, Zerrin Özergin; Çeliker, Metin; Oğhan, Fatih; Mercantepe, Tolga; Terzi, Suat; Dursun, Engin (Springer, 2018)
The aim of this prospective animal study is to investigate the influence of multiple administrations of macrocyclic ionic (gadoteric acid) and linear nonionic (gadodiamide) gadolinium-based contrast agents (GBCA) on ...
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Mercantepe, Tolga (31)
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