• Türkçe
    • English
  • Türkçe 
    • Türkçe
    • English
  • Giriş
Öğe Göster 
  •   RTEÜ
  • Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed
  • WoS İndeksli Yayınlar Koleksiyonu
  • Öğe Göster
  •   RTEÜ
  • Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed
  • WoS İndeksli Yayınlar Koleksiyonu
  • Öğe Göster
JavaScript is disabled for your browser. Some features of this site may not work without it.

Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity

Thumbnail

Göster/Aç

Full Text / Tam Metin (1.483Mb)

Erişim

info:eu-repo/semantics/openAccess

Tarih

2018

Yazar

Mercantepe, Tolga
Kalkan, Yıldıray
Tümkaya, Levent
Şehitoğlu, İbrahim
Mercantepe, Filiz
Yıldırmış, Sermet

Üst veri

Tüm öğe kaydını göster

Künye

Mercantepe, T., Kalkan, Y., Tumkaya, L., Sehitoglu, İ., Mercantepe, F., & Yıldırmıs, S. (2018). Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity. Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 27(6), 715–720. https://doi.org/10.17219/acem/68967

Özet

Background. Methotrexate (MTX), a folate antagonist, is commonly used in the treatment of many different types of cancer and inflammatory diseases, including pancreatic cancer, although its side effects on the pancreas have not yet been researched. the mechanism of MTX-induced toxicity is not well known, and it has been reported in high-dose toxicity studies that the pancreas is sensitive to toxic effects. Objectives. the aim of our study was to determine whether adalimumab (ADA) has a preventive effect on MTX-induced pancreas toxicity in rats. Material and methods. the rats were equally and randomly divided into 3 groups (Group 1 comprised the healthy controls, Group 2 was the MTX group, and Group 3 was the MTX +ADA group). the rats in Groups 2 and 3 received an intraperitoneal (ip.) single-dose injection of MTX (20 mg/kg). A single dose of 5 mg/kg ADA (REMICADE (R)) was administered ip. to Group 3. All the rats were sacrificed under anesthesia 5 days after receiving the MTX injection. Results. Significantly higher mean edema, necrotic cell, and inflammatory scores were recorded in Groups 2 and 3 compared to those recorded in Group 1. Significantly decreased edema, number of necrotic cells, and inflammatory scores were noted in Group 3 than in Group 2. A decrease in islets of Langerhans cell insulin and somatostatin-positive interneurons was demonstrated after the administration of MTX. An increase in insulin and somatostatin-positive cells in islets of Langerhans, as well as a remodeling of the structure of the pancreas, was shown following treatment with ADA. Conclusions. Adalimumab was demonstrated to have a protective effect against MTX-induced pancreatic injury in this study.

Kaynak

Advances in Clinical and Experimental Medicine

Cilt

27

Sayı

6

Bağlantı

https://doi.org/10.17219/acem/68967
https://hdl.handle.net/11436/1819

Koleksiyonlar

  • PubMed İndeksli Yayınlar Koleksiyonu [2440]
  • Scopus İndeksli Yayınlar Koleksiyonu [5917]
  • TF, Dahili Tıp Bilimleri Bölümü Koleksiyonu [1555]
  • TF, Temel Tıp Bilimleri Bölümü Koleksiyonu [690]
  • WoS İndeksli Yayınlar Koleksiyonu [5260]



DSpace software copyright © 2002-2015  DuraSpace
İletişim | Geri Bildirim
Theme by 
@mire NV
 

 




| Yönerge | Rehber | İletişim |

DSpace@RTEÜ

by OpenAIRE
Gelişmiş Arama

sherpa/romeo

Göz at

Tüm DSpaceBölümler & KoleksiyonlarTarihe GöreYazara GöreBaşlığa GöreKonuya GöreTüre GöreDile GöreBölüme GöreKategoriye GöreYayıncıya GöreErişim ŞekliKurum Yazarına GöreBu KoleksiyonTarihe GöreYazara GöreBaşlığa GöreKonuya GöreTüre GöreDile GöreBölüme GöreKategoriye GöreYayıncıya GöreErişim ŞekliKurum Yazarına Göre

Hesabım

GirişKayıt

İstatistikler

Google Analitik İstatistiklerini Görüntüle

DSpace software copyright © 2002-2015  DuraSpace
İletişim | Geri Bildirim
Theme by 
@mire NV
 

 


|| Rehber|| Yönerge || Kütüphane || Recep Tayyip Erdoğan Üniversitesi || OAI-PMH ||

Recep Tayyip Erdoğan Üniversitesi, Rize, Türkiye
İçerikte herhangi bir hata görürseniz, lütfen bildiriniz:

Creative Commons License
Recep Tayyip Erdoğan Üniversitesi Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

DSpace@RTEÜ:


DSpace 6.2

tarafından İdeal DSpace hizmetleri çerçevesinde özelleştirilerek kurulmuştur.