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Küçük Resim

Influences of periodontitis on hippocampal inflammation, oxidative stress, and apoptosis in rats 

Köse, Oğuz; Altın, Ahmet; Bayrakdar, Sevda Kurt; Bostan, Semih Alperen; Mercantepe, Tolga; Akyıldız, Kerimali; Tümkaya, Levent; Yılmaz, Adnan; Köse, Sefanur; Yemenoğlu, Hatice; Şener, Leyla Türker; Göker, Kuluslu (Wiley, 2021)
Background and aim The hippocampus, which has a central role in cognitive and behavioral activities, is one of the most sensitive parts of the brain to systemic inflammatory diseases. This animal study aims to comprehensively ...
Küçük Resim

Effects of long-term Doppler ultrasound exposure on cochlea and cochlear nucleus in prenatal period in an experimental model 

Çeliker, Metin; Beyazal Çeliker, Fatma; Tümkaya, Levent; Oğhan, Fatih; Özgür, Abdulkadir; Mercantepe, Tolga; Terzi, Suat; Beyazal, Mehmet; Turan, Arzu; Çınar, Seda; Zengin, Ertan; Demir, Emine; Dursun, Engin (Taylor & Francis Ltd., 2021)
Background New generation Doppler ultrasonography (DUSG) application effects on cochlea and cochlear nucleus (CN) are unclear. We aimed to investigate the effects of new generation DUSG application at different frequencies ...
Küçük Resim

The effect of dexmedetomidine on liver injury secondary to lower extremity ischemia-reperfusion in a diabetic rat model 

Kartal, Seyfi; Şen, Ahmet; Tümkaya, Levent; Erdivanlı, Başar; Mercantepe, Tolga; Yılmaz, Adnan (Taylor & Francis Ltd., 2021)
Introduction: In this study, we aimed to evaluate the hepatic protective effects of dexmedetomidine in the lower extremity ischemia-reperfusion model in diabetic rats biochemically and histopathologically. Methods: Rats ...
Küçük Resim

Can dexmedetomidine be effective in the protection of radiotherapy-induced brain damage in the rat? 

Çınar, Seda; Tümkaya, Levent; Mercantepe, Tolga; Saral, Sinan; Rakıcı, Sema; Yılmaz, Adnan; Topçu, Atilla; Şen, Ahmet; Karakaş, Sibel (Springer, 2021)
Approximately 7 million people are reported to be undergoing radiotherapy (RT) at any one time in the world. However, it is still not possible to prevent damage to secondary organs that are off-target. This study, therefore, ...
Küçük Resim

Effects of gadodiamide and gadoteric acid on lung tissue: A comparative study 

Çeliker, Fatma Beyazal; Tümkaya, Levent; Suzan, Zehra T.; Topçu, Atilla; Mercantepe, Tolga; Çınar, Seda; Yazıcı, Zihni Açar; Yılmaz, Adnan (Wiley, 2022)
We set out to investigate the effects of gadodiamide and gadoteric acid, used for magnetic resonance imaging, on the lungs. In this study, 32 male Sprague Dawley rats were used. These were allocated into four groups; The ...
Küçük Resim

The effects of long-term doppler ultrasound exposure in the prenatal period on renal tissue physiology in rats 

Çeliker, Fatma Beyazal; Tümkaya, Levent; Mercantepe, Tolga; Zengin, Ertan; Beyazal, Mehmet; Turan, Arzu; Polat, Hatice Beyazal; Suzan, Zehra Topal; Yılmaz, Adnan (Taylor & Francis Inc., 2022)
Doppler ultrasonography (DUSG) is widely used for fetal evaluations. This study investigated the effects of new generation Doppler ultrasound application at different frequencies during pregnancy on postnatal renal ...
Küçük Resim

Dexmedetomidine attenuates pneumocyte apoptosis and inflammation induced by aortic ischemia-reperfusion injury 

Hemşinli, Doğuş; Tümkaya, Levent; Ergene, Şaban; Karakişi, Sedat Ozan; Mercantepe, Tolga; Yılmaz, Adnan (Taylor & Francis Ltd., 2022)
Objective Despite significant improvements in interventional vascular aneurysm repair procedures and intensive care patient management, there has been no significant decrease in mortality due to ruptured abdominal aortic ...
Küçük Resim

The cardioprotective effects of perindopril in a model of polymicrobial sepsis: The role of radical oxygen species and the inflammation pathway 

Topçu, Atilla; Kostakoğlu, Uğur; Mercantepe, Tolga; Yılmaz, Hülya K.; Tümkaya, Levent; Uydu, Hüseyin Avni (Wiley, 2022)
Mortality rates associated with myocardial dysfunction due to sepsis and septic shock are generally high across the world. The present study focused on the antioxidant and anti-inflammatory effects of perindopril (PER) for ...
Küçük Resim

Effect of the prenatal electromagnetic field exposure on cochlear nucleus neurons and oligodendrocytes in rats 

Tümkaya, Levent; Baş, Orhan; Mercantepe, Tolga; Çınar, Seda; Özgür, Abdulkadir; Yazıcı, Zihni Açar (Springer Heidelberg, 2022)
Electromagnetic radiation from elecromagnetic field (EMF) sources has been an important health concern for a long time. The vast majority of this exposure is due to the widespread use of mobile phones, an important source ...
Küçük Resim

The protective effect of astaxanthin on cisplatin-induced ototoxicity 

Terzi, Suat; Özgür, Abdulkadir; Çeliker, Metin; Mercantepe, Tolga; Yılmaz, Adnan; Tümkaya, Levent; Kaya, Şeyma; Demir, Emine; Dursun, Engin (Wroclaw Medical Univercity, 2021)
Background. Promising studies have been conducted with many substances to reduce the ototoxic effects of cisplatin, but there is no treatment that completely eliminates the ototoxic effect. Objectives. To determine the ...
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