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Effects of long-term Doppler ultrasound exposure on cochlea and cochlear nucleus in prenatal period in an experimental model

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Erişim

info:eu-repo/semantics/closedAccess

Tarih

2021

Yazar

Çeliker, Metin
Beyazal Çeliker, Fatma
Tümkaya, Levent
Oğhan, Fatih
Özgür, Abdulkadir
Mercantepe, Tolga
Terzi, Suat
Beyazal, Mehmet
Turan, Arzu
Çınar, Seda
Zengin, Ertan
Demir, Emine
Dursun, Engin

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Künye

Celiker, M., Beyazal Celiker, F., Tumkaya, L., Oghan, F., Ozgur, A., Mercantepe, T., Terzi, S., Beyazal, M., Turan, A., Cinar, S., Zengin, E., Demir, E., & Dursun, E. (2021). Effects of long-term Doppler ultrasound exposure on cochlea and cochlear nucleus in prenatal period in an experimental model. The journal of maternal-fetal & neonatal medicine, 1-8. https://doi.org/10.1080/14767058.2021.1875431

Özet

Background New generation Doppler ultrasonography (DUSG) application effects on cochlea and cochlear nucleus (CN) are unclear. We aimed to investigate the effects of new generation DUSG application at different frequencies in prenatal period on cochlea and CN in rats. Objective Twenty-four pregnant female rats were divided into three groups (n = 8). Group 1 was the control group and was not subjected to any treatment. Group 2 was determined as the USG every day (USGED) treatment group. Group 2 has received DUSG application every day from the 4th to 18th day (20 min/15 per day). Group 3 has received DUSG application as "2 days/one dose as every other day application" (USG2D1) from the 4th to 18th day (20 min/8 every other day). Twenty-four female rats were sacrificed in 21 days. Also, 24 pups were sacrificed after two days. First day after born, the cochlear activities of the right ears of all pups were examined using DPOAEs. Second day, neural tissues from CN were evaluated histopathologically and immunohistochemically. Results There was no any statistical difference between the groups in respect of histopathologically. USGED group showed mild caspase-3 positive neurons and glial cells. However, there was no significant difference between the USGED and other groups (p>.05). Similarly, the rats applied with USG2D1 had mild caspase-3 expression, but no significant difference between the USG2D1 and other groups (p>.05). Differences in DPOAE amplitudes, and therefore in cochlear activity, between the groups were revealed. The decrease in cochlear activity between the groups involved frequencies at 2, 8, 16, and 32 kHz (p<.05). Conclusions Multiple administration of new generation DUSG to pregnant rats has not shown harmful effects on the cochlear neural tissue. High frequencies are more sensitive in cochlea to apply DUSG.

Kaynak

The Journal of Maternal-Fetal & Neonatal Medicine

Bağlantı

https://doi.org/10.1080/14767058.2021.1875431
https://hdl.handle.net/11436/6592

Koleksiyonlar

  • PubMed İndeksli Yayınlar Koleksiyonu [2443]
  • Scopus İndeksli Yayınlar Koleksiyonu [5990]
  • TF, Cerrahi Tıp Bilimleri Bölümü Koleksiyonu [1220]
  • TF, Temel Tıp Bilimleri Bölümü Koleksiyonu [698]
  • WoS İndeksli Yayınlar Koleksiyonu [5260]



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