Ara
Toplam kayıt 30, listelenen: 21-30
A simple and efficient synthesis of benzimidazoles containing piperazine or morpholine skeleton at C-6 position as glucosidase inhibitors with antioxidant activity
(Academic Press Inc Elsevier Science, 2018)
A novel 2-(aryl)-6-morpholin-4-yl(or 4-methylpiperazin-1-yl)-1H-benzimidazole derivatives were designed and expeditiously synthesized starting from 5-morpholin-4-yl(or 4-methylpiperazin-1-yl)-2-nitroaniline with various ...
Synthesis, molecular docking and biological evaluation of some benzimidazole derivatives as potent pancreatic lipase inhibitors
(Academic Press Inc Elsevier Science, 2018)
In this study, a new series of benzimidazole and bisbenzimidazole derivatives were prepared via the reaction of iminoester hydrochlorides and o-phenylenediamines and then screened for their lipase inhibition properties. ...
Synthesis and antioxidant, antiurease and anti-xanthine oxidase activities of some new benzimidazoles bearing triazole, oxadiazole, thiadiazole and imin function
(Natl Inst Science Communication & Information Resources-Niscair, 2018)
In this study, a series of new 2-(4-nitrobenzyl)-1H-benzimidazole derivatives bearing thiosemicarbazide, triazole, oxadiazole and thiadiazole moieties at the 1st position of benzimidazole ring have been synthesized and ...
Synthesis, inhibitory properties on the metabolic enzymes and antioxidant activity of a new series benzimidazole derivatives
(Editura Acad Romane, 2019)
In this study, a series of new 1, 2-disubstituted benzimidazole was synthesized starting from 5, 6-dichloro-2-(4-methoxybenzyl)-1H-benzimidazole compound which was converted to the ester and hydrazide derivative, respectively. ...
Design, molecular docking and synthesis of novel 5,6-dichloro-2-methyl-1H-benzimidazole derivatives as potential urease enzyme inhibitors
(Academic Press Inc Elsevier Science, 2019)
A novel series of 5,6-dichloro-2-methyl-1H-benzimidazole derivatives was synthesized and then screened for their urease inhibitory activity. All compounds showed more potent inhibitory activity in the range of IC50= 0.0294 ...
Synthesis and characterization of ring-type and branched polymers including polyethylene glycols by "click" chemistry
(Springer International Publishing Ag, 2019)
Synthesis of ring-type (or branched) polymers including polyethylene glycols was archived via "click" chemistry of 5,6-diazido-2-benzyl-1H-benzimidazole (Di-N-3) [or triazidoacetohydrazide derivative (Tri-N-3)] and terminally ...
Synthesis, alpha-glucosidase inhibition and in silico studies of some 4-(5-fluoro-2-substituted-1H-benzimidazol-6-yl)morpholine derivatives
(Academic Press Inc Elsevier Science, 2020)
In this study, a new series of 4-(5-fluoro-2-substituted-1H-benzimidazol-6-yl)morpholine derivatives has been synthesized and screened for their alpha-glucosidase inhibitory potential. All molecules showed a considerable ...
Synthesis of some benzimidazole-thiophene hybrids as potential urease and lipase inhibitors
(Springer Link, 2023)
In this study, some benzimidazole-thiophene hybrid compounds containing isatin and salicyl moieties were synthesized and investigated for their urease and lipase inhibition properties. Most of the synthesized compounds ...
Developing effective antimicrobial agents: synthesis and molecular docking study of ciprofloxacin-benzimidazole hybrids
(Wiley, 2024)
In this study, we designed and synthesized some new ciprofloxacin-benzimidazole hybrid compounds and evaluated them for their antimicrobial activity against four Gram-positive (B. subtilis, B. megaterium, E. faecalis and ...
Synthesis of benzimidazoles containing piperazine ring as potential therapeutic agents against diabetes mellitus and antioxidant activities
(Elsevier, 2024)
We synthesized a novel 6-(4-substitue-piperazin-1-yl)-2-aryl-1H-benzimidazole derivatives starting from 5-(4-substitue-piperazin-1-yl)-2-nitroaniline with different aldehydes. A quick "onepot" nitro reductive cyclization ...