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Toplam kayıt 136, listelenen: 31-40

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Küçük Resim

Melatonin improves periodontitis-induced kidney damages by decreasing inflammatory stress and apoptosis in rats 

Köse, Oğuz; Bayrakdar, Sevda Kurt; Ünver, Büşra; Altın, Ahmet; Akyıldız, Kerimali; Mercantepe, Tolga; Bostan, Semih Alperen; Arabacı, Taner; Türker Şener, Leyla; Köse, Taha Emre; Tümkaya, Levent; Yılmaz, Adnan; Kuluşlu, Göker (Wiley-Blackwell, 2020)
Background: Two main aims of this animal study were to inspect the possible effects of periodontitis on the structure and functions of the kidneys and the therapeutic effectiveness of melatonin. Methods: Twenty-four male ...
Küçük Resim

Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture 

Karakişi, Sedat Ozan; Hemşinli, Doğuş; Tümkaya, Levent; Ergene, Şaban; Mercantepe, Tolga; Yılmaz, Adnan (Baycinar Medical Publishing-Bayçınar Tıbbi Yayıncılık, 2021)
Background: The aim of this study was to examine the effects on the lungs of ischemia/reperfusion injury in a ruptured abdominal aortic aneurysm model in rats and to investigate the potential protective effects of ...
Küçük Resim

Comparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage 

Şafak, Gökhan; Çeliker, Metin; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema; Çınar, Seda; Yılmaz, Adnan; Terzi, Suat; Demir, Emine; Erdivanlı, Özlem Çelebi; Coşkun, Zerrin Özergin; Karakaş, Sibel; Birinci, Mehmet; Dursun, Engin (Springer, 2022)
Radiotherapy can be employed as a therapeutic modality alone in the early stages of cancer and is used together with other treatments such as surgery and chemotherapy in more advanced stages. However, exposure to ionizing ...
Küçük Resim

Inhibition of methotrexate induced toxicity in the adult rat spleen by adalimumab 

Bahçeci, İlkay; Tümkaya, Levent; Mercantepe, Tolga; Aslan, Nuray; Duran, Ömer Faruk; Söztanacı, Umut Serkan; Yazıcı, Zihni Açar (Taylor & Francis Ltd., 2022)
Methotrexate (MTX) has been in use for the treatment of rheumatoid arthritis (RA), psoriasis, and cancer since 1948. Its toxic side effects on tissues and organs have been well documented but splenotoxicity has not been ...
Küçük Resim

The nephroprotective effect of amifostine in a cecal ligation-induced sepsis model in terms of oxidative stress and inflammation 

Batçık, Şule; Tümkaya, Levent; Mercantepe, Tolga; Atak, Mehtap; Topçu, Atilla; Uydu, Hüseyin Avni; Mercantepe, F. (Verduci Editore, 2022)
OBJECTIVE: Sepsis is responsible for more than 5 million deaths worldwide every year. The purpose of this study was to use amifostine to reduce acute kidney injury developing as a result of sepsis. MATERIALS AND METHODS: ...
Küçük Resim

Histopathological evaluation of the effects of dexmedetomidine against pituitary damage ınduced by X-ray irradiation 

Mercantepe, Filiz; Tümkaya, Levent; Mercantepe, Tolga; Rakıcı, Sema (Taylor & Francis Ltd., 2022)
Background: The present study, aimed to investigate the potential negative effects of x-ray radiation and the effects of the α2-adrenergic receptor agonist dexmedetomidine on the pituitary gland. Methods: Twenty-four ...
Küçük Resim

The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal aorta clamping 

Karakişi, Sedat Ozan; Hemşinli, Doğuş; Tümkaya, Levent; Ergene, Şaban; Mercantepe, Tolga; Yılmaz, Adnan (Effect Publishing Agency ( EPA ), 2021)
Objectives: This study aims to examine the potential protective effect of the selective alpha-2 adrenergic receptor agonist dexmedetomidine (DEX) against aortic occlusion-induced myocardial injury. Patients and methods: ...
Küçük Resim

The effects of TNF-alpha inhibitors on carbon tetrachloride-induced nephrotoxicity 

Özdemir, Ali; Tümkaya, Levent; Kalcan, Süleyman; Uyan, Mikail; Karakaya, Ahmet; Demiral, Gökhan; Samancı, Tuğba Çelik; Mercantepe, Tolga; Cüre, Medine Cumhur; Cüre, Erkan (Taylo & Francis Ltd., 2021)
Objectives: Carbon tetrachloride (CCl4), employed in various industrial fields, can cause acute damage in renal tissues. This study investigated the therapeutic effect of the TNF-alpha inhibitor Infliximab on TGF-beta and ...
Küçük Resim

Comparison of linear versus macrocyclic gadolinium chelates in rat skeletal muscle 

Balık, Mehmet Sabri; Çeliker, Fatma Beyazal; Tümkaya, Levent; Mercantepe, Tolga; Topçu, Atilla; Şahin, Rıfat; Balık, Gülşah (2022)
OBJECTIVE: We investigated the effects on skeletal muscle of gadolinium based linear and macrocyclic radiocontrast agents applied at experimental intervals using histopathological methods. METHODS: Thirty-two male ...

Clinical and histologic evaluation of partial achilles tendon ınjury repair with amniotic membrane in rats 

Mantı, Nurettin; Güvercin, Yılmaz; Mercantepe, Tolga; Tümkaya, Levent; Balık, Mehmet Sabri (2022)
Background: Adhesions after tendinopathy in individuals who perform physical work and those physically active in middle age are a challenging problem for orthopedic surgeons. We evaluated the effects of human-derivated ...
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