dc.contributor.author | Kalaycıoğlu, Ezgi | |
dc.contributor.author | Çetin, Mustafa | |
dc.contributor.author | Çinier, Göksel | |
dc.contributor.author | Kırış, Tuncay | |
dc.contributor.author | Gökdeniz, Tayyar | |
dc.contributor.author | Özyıldız, Ali Gökhan | |
dc.contributor.author | Durmus, Ismet | |
dc.date.accessioned | 2020-12-19T19:34:35Z | |
dc.date.available | 2020-12-19T19:34:35Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Kalaycıoğlu, E., Çetin, M., Çinier, G., Kırış, T., Gökdeniz, T., Özyıldız, A.G., Durmuş, İ. (2020). Serum osteoprotegerin level is independently related to subclinical left atrial mechanical function in patients with hypertension and diabetes. Herz. | |
dc.identifier.issn | 0340-9937 | |
dc.identifier.issn | 1615-6692 | |
dc.identifier.uri | https://doi.org/10.1007/s00059-020-04939-7 | |
dc.identifier.uri | https://hdl.handle.net/11436/1126 | |
dc.description | Cetin, Mustafa/0000-0001-6342-436X; KALAYCIOGLU, EZGI/0000-0003-2122-1817 | en_US |
dc.description | WOS: 000556232600001 | en_US |
dc.description | PubMed: 32462219 | en_US |
dc.description.abstract | Objectives Previous studies showed that subclinical abnormal left atrial (LA) function could be diagnosed with LA speckle tracking evaluation long before chamber enlargement. Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor superfamily and was recently found to be an indicator for adverse cardiovascular outcomes and a risk factor for new onset atrial fibrillation. the authors hypothesized that OPG values could predict LA mechanical dysfunction and LA remodeling assessed by two-dimensional speckle tracking echocardiography (2D-STE) in patients with hypertension (HT) and diabetes mellitus (DM). Methods A single center study was conducted including consecutive patients presenting to the authors' outpatient clinic. Enrolled patients needed to have been treated for HT and DM for at least 1 year. Results the study included 80 patients (mean age, 57.5 +/- 8.3 years). Patients in the impaired LA strain group were older (p = 0.035), had lower low density lipoprotein (LDL) cholesterol (mg/dl) (p = 0.021), and higher OPG (pmol/l) (p = 0.004) values than patients in the normal LA strain group. Univariate logistic regression analysis demonstrated that age (p = 0.039), LDL cholesterol (mg/dl) (p = 0.025), and OPG (pmol/l) (p = 0.008) values were associated with impaired LA strain. Backward multivariate logistic regression analysis showed that LDL cholesterol (mg/dl) (OR: 0.982, CI 95% 0.964-0.999,p = 0.049) and OPG (pmol/l) (OR: 1.438, CI 95% 1.043-1.983,p = 0.027) were independently associated with impaired LA strain. Conclusion in hypertensive and diabetic patients, higher OPG values were associated with impaired LA function assessed by 2D-STE. in this high-risk patient group, serum OPG can be used as a risk predictor for LA mechanical dysfunction. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Urban & Vogel | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Atrial fibrillation | en_US |
dc.subject | Cholesterol | en_US |
dc.subject | LDL | en_US |
dc.subject | Vascular system | en_US |
dc.subject | Left atrium | en_US |
dc.subject | Two-dimensional speckle tracking echocardiography | en_US |
dc.title | Serum osteoprotegerin level is independently related to subclinical left atrial mechanical function in patients with hypertension and diabetes | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Çetin, Mustafa | |
dc.contributor.institutionauthor | Özyıldız, Ali Gökhan | |
dc.identifier.doi | 10.1007/s00059-020-04939-7 | |
dc.relation.journal | Herz | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |