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dc.contributor.authorAydın, Mehmet Dumlu
dc.contributor.authorKanat, Ayhan
dc.contributor.authorHacımüftüoğlu, Ahmet
dc.contributor.authorÖzmen, Sevilay
dc.contributor.authorAhıskalıoğlu, Ali
dc.contributor.authorKoçak, Mehmet Nuri
dc.date.accessioned2020-12-19T19:34:52Z
dc.date.available2020-12-19T19:34:52Z
dc.date.issued2020
dc.identifier.citationAydin, M. D., Kanat, A., Hacimuftuoglu, A., Ozmen, S., Ahiskalioglu, A., & Kocak, M. N. (2020). A new experimental evidence that olfactory bulb lesion may be a causative factor for substantia nigra degeneration; preliminary study. The International journal of neuroscience, 131(3), 220–227. https://doi.org/10.1080/00207454.2020.1737049en_US
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.urihttps://doi.org/10.1080/00207454.2020.1737049
dc.identifier.urihttps://hdl.handle.net/11436/1190
dc.descriptionozmen, sevilay/0000-0002-1973-6101; Ahiskalioglu, Ali/0000-0002-8467-8171; Kanat, Ayhan/0000-0002-8189-2877en_US
dc.descriptionWOS: 000519326400001en_US
dc.descriptionPubMed: 32114876en_US
dc.description.abstractBackground: Anosmia has been considered as the first diagnostic criteria of Parkinson disease (PD), we investigated the effect of the olfactory bulbectomy (OBX) on histopathological features of the substantia nigra in an animal model. Methods: Twenty-seven male rats were used in this study. Animals were divided into three groups as five (control), six SHAM and sixteen study (OBL) groups. Nothing was done in the control group, the only burr hole was done in the SHAM group, OBL was not applied, and bilateral OBL was performed in the study group, and followed ten weeks, then animals were decapitated. Olfactory bulb volumes were measured by macro anatomically. the olfactory bulbs and substantia nigra sections were analyzed by a stereological method to evaluate olfactory glomerulus and neuron density of substantia nigra per cubic centimeter and compared with statistically. Results: the mean olfactory bulb volume, degenerated olfactory glomerulus density and degenerated neuron density of substantia nigra were measured as:(4.14 +/- 0.20) mm(3), (1 +/- 1)/mm(3) and (7 +/- 2)/mm(3) in control (Group I); (3.6 +/- 0.16)/mm(3), (4 +/- 1)/mm(3) and(32 +/- 7)/mm(3) in SHAM (Group II) and (2.2 +/- 0.9)/mm(3), (112 +/- 18)/mm(3) and (1543 +/- 115)/mm(3)in study group (Group III). Diminished olfactory bulb volume was observed in Group III animals. Conclusions: We concluded that OBL may lead to the degeneration of substantia nigra.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOlfactory bulb lesionen_US
dc.subjectSubstantia nigraen_US
dc.subjectDegenerationen_US
dc.subjectParkinson's diseaseen_US
dc.titleA new experimental evidence that olfactory bulb lesion may be a causative factor for substantia nigra degeneration; preliminary studyen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorKanat, Ayhan
dc.identifier.doi10.1080/00207454.2020.1737049
dc.identifier.volume131en_US
dc.identifier.issue3en_US
dc.identifier.startpage220en_US
dc.identifier.endpage227en_US
dc.relation.journalInternational Journal of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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