dc.contributor.author | Gürkan, Çağla Gül | |
dc.contributor.author | Keleş, Gonca Çayır | |
dc.contributor.author | Kurt, Sevda | |
dc.contributor.author | Çiftçi, Alper | |
dc.contributor.author | Ayas, Bülent | |
dc.contributor.author | Güler, Şevki | |
dc.contributor.author | Çetinkaya, Burcu Özkan | |
dc.date.accessioned | 2020-12-19T19:35:55Z | |
dc.date.available | 2020-12-19T19:35:55Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Gürkan, Ç. G., Keleș, G. Ç., Kurt, S., Çiftçi, A., Ayas, B., Güler, Ş., & Çetinkaya, B. Ö. (2019). Histopathological and biochemical evaluation of paeoniflorin administration in an experimental periodontitis model. Journal of oral science, 61(4), 554–557. https://doi.org/10.2334/josnusd.18-0427 | en_US |
dc.identifier.issn | 1343-4934 | |
dc.identifier.issn | 1880-4926 | |
dc.identifier.uri | https://doi.org/10.2334/josnusd.18-0427 | |
dc.identifier.uri | https://hdl.handle.net/11436/1370 | |
dc.description | KURT, Sevda/0000-0002-3711-6520 | en_US |
dc.description | WOS: 000509391800015 | en_US |
dc.description | PubMed: 31588098 | en_US |
dc.description.abstract | The purpose of this study was to evaluate the effects of administered Paeoniflorin (Pae) on periodontal tissues within an experimental periodontitis model. Forty male Wistar rats were used in this study and experimental periodontitis was created in all rats except in the control group (n = 10, first group). in the periodontitis group, experimental periodontitis was created but no other application was performed (n = 10, second group). in the other groups created experimental periodontitis, systemic Pae (n = 10, third group) or saline (n = 10, fourth group) was applied. A biochemical analysis of the gingival vascular endothelial growth factor (VEGF) levels and a histomorphometric analysis (measurements of the area of alveolar bone, alveolar bone resorption, and attachment loss) were performed. in the Pae group, the area of the alveolar bone was increased, while alveolar bone resorption and attachment loss decreased. Gingival VEGF levels increased in all groups that created experimental periodontitis and the greatest increase seen in the Pae group. Histomorphometric and biochemical analyses in this study suggest that Pae has a curative effect on periodontal tissues. However, additional studies are needed to confirm these results. | en_US |
dc.description.sponsorship | Scientific Research Fund of Ondokuz Mayis University in Samsun/TurkeyOndokuz Mayis University [PYO.DIS.1904.15.001] | en_US |
dc.description.sponsorship | This study was supported by the Scientific Research Fund of Ondokuz Mayis University in Samsun/Turkey (Project number: PYO.DIS.1904.15.001). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nihon Univ, School Dentistry | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Experimental periodontitis | en_US |
dc.subject | Histology | en_US |
dc.subject | Herbal medicine | en_US |
dc.title | Histopathological and biochemical evaluation of paeoniflorin administration in an experimental periodontitis model | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü | en_US |
dc.contributor.institutionauthor | Kurt, Sevda | |
dc.identifier.doi | 10.2334/josnusd.18-0427 | |
dc.identifier.volume | 61 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 554 | en_US |
dc.identifier.endpage | 557 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | Journal of Oral Science | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |