Show simple item record

dc.contributor.authorTaflan, Ebru
dc.contributor.authorBayrak, Hacer
dc.contributor.authorEr, Mehtap
dc.contributor.authorKaraoğlu, Şengül Alpay
dc.contributor.authorBozdeveci, Arif
dc.date.accessioned2020-12-19T19:36:41Z
dc.date.available2020-12-19T19:36:41Z
dc.date.issued2019
dc.identifier.citationTaflan, E., Bayrak, H., Er, M., Alpay Karaoğlu, Ş., & Bozdeveci, A. (2019). Novel imidazo[2,1-b][1,3,4]thiadiazole (ITD) hybrid compounds: Design, synthesis, efficient antibacterial activity and antioxidant effects. Bioorganic chemistry, 89, 102998. https://doi.org/10.1016/j.bioorg.2019.102998en_US
dc.identifier.issn0045-2068
dc.identifier.issn1090-2120
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2019.102998
dc.identifier.urihttps://hdl.handle.net/11436/1468
dc.descriptionAlpay Karaoglu, Sengul/0000-0003-1047-8350; BOZDEVECI, ARIF/0000-0002-0729-9143en_US
dc.descriptionWOS: 000476615700032en_US
dc.descriptionPubMed: 31128819en_US
dc.description.abstractIn this study, novel imidazo[2,1-b] [1,3,4]thiadiazole (ITD) compounds were synthesized and their antimicrobial and antioxidant capacity was examined. the C-2 position of the ITD structure was fixed with the 3,4-hydroxybenzene ring and the properties of the two series of compounds obtained by phenyl or 4-chlorophenyl in the C-6 position were compared. in the formation of these series, new properties were determined by the addition of different pharmacophore to the target product by binding of the groups known in the literature from the C-5 position to the structure. in the study, it was seen that the compounds 4a, 4b, 5a, 5b, 7f, 10, 12 and 13 had very high anti-tuberculosis activities at low concentrations, 3b was found to exhibit moderate activity while other synthesis compounds exhibited moderate activity. in addition, it showed activity against gram positive and negative bacteria. in the determination of the antioxidant capacities of the newly synthesized compounds by FRAP and DPPH methods, the compounds showing activity were found to be 2, 3a, 3b, 6c, 9, 11 and 13. the structures of all synthesized compounds were solved by spectroscopic methods such as FT-IR, H-1 NMR, C-13 NMR and mass.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [117Z422]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) [grant number 117Z422].en_US
dc.language.isoengen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImidazo [2,1-b] [1,3,4] thiadiazoleen_US
dc.subject1,3-thiazolidin-4-oneen_US
dc.subjectAntimicrobial activityen_US
dc.subjectAntioxidant activityen_US
dc.subjectMannich basesen_US
dc.titleNovel imidazo[2,1-b] [1,3,4]thiadiazole (ITD) hybrid compounds: Design, synthesis, efficient antibacterial activity and antioxidant effectsen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Fen - Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.contributor.institutionauthorKaraoğlu, Şengül Alpay
dc.contributor.institutionauthorBozdeveci, Arif
dc.identifier.doi10.1016/j.bioorg.2019.102998
dc.identifier.volume89en_US
dc.relation.journalBioorganic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record