dc.contributor.author | Hacıislamoğlu, Emel | |
dc.contributor.author | Çınar, Yunus | |
dc.contributor.author | Gürcan, Fatih | |
dc.contributor.author | Canyılmaz, Emine | |
dc.contributor.author | Güngör, Görkem | |
dc.contributor.author | Yöney, Adnan | |
dc.date.accessioned | 2020-12-19T19:40:46Z | |
dc.date.available | 2020-12-19T19:40:46Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Haciislamoglu, E., Cinar, Y., Gurcan, F., Canyilmaz, E., Gungor, G., & Yoney, A. (2019). Secondary cancer risk after whole-breast radiation therapy: field-in-field versus intensity modulated radiation therapy versus volumetric modulated arc therapy. The British journal of radiology, 92(1102), 20190317. https://doi.org/10.1259/bjr.20190317 | |
dc.identifier.citation | | en_US |
dc.identifier.issn | 0007-1285 | |
dc.identifier.issn | 1748-880X | |
dc.identifier.uri | https://doi.org/10.1259/bjr.20190317 | |
dc.identifier.uri | https://hdl.handle.net/11436/1642 | |
dc.description | Haciislamoglu, Emel/0000-0003-3411-2142; GUNGOR, GORKEM/0000-0001-8164-8877 | en_US |
dc.description | WOS: 000487250000020 | en_US |
dc.description | PubMed: 31295011 | en_US |
dc.description.abstract | Objective: in this study, we used the concept of organ-equivalent dose (OED) to evaluate the excess absolute risk (EAR) for secondary cancer in various organs after radiation treatment for breast cancer. Methods: Using CT data set of 12 patients, we generated three different whole-breast radiation treatment plans using 50 Gy in 2Gy fractions: three-dimensional conformal radiotherapy with a field-in-field (FinF) technique, intensity modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT). the OEDs were calculated from differential dose-volume histograms on the basis of the "linear-exponential," "plateau," and ''full mechanistic" dose-response models. Secondary cancer risks of the contralateral breast (CB), contralateral lung (CL), and ipsilateral lung (IL) were estimated and compared. Results: the lowest EARs for the CB, CL, and IL were achieved with FinF, which reduced the EARs by 77%, 88%. and 56% relative to those with IMRT, and by 77%, 84%, and 58% relative to those with VMAT, respectively. the secondary cancer risk for FinF was significantly lower than those of IMRT and VMAT. OED-based secondary cancer risks for CB and IL were similar when IMRT and VMAT were used, but the risk for CL was statistically lower when VMAT was used. Conclusion: the overall estimation of EAR indicated that the radiation-induced cancer risk of breast radiation therapy was lower with FinF than with IMRT and VMAT. Therefore, when secondary cancer risk is a major concern, FinF is considered to be the preferred treatment option in irradiation of whole-breast. Advances in knowledge: Secondary malignancy estimation after breast radiotherapy is becoming an important subject for comparative treatment planning.When secondary cancer risk a major concern, FinF technique is considered the preferred treatment option in whole breast patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | British Inst Radiology | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | [0-Belirlenecek] | en_US |
dc.title | Secondary cancer risk after whole-breast radiation therapy: field-in-field versus intensity modulated radiation therapy versus volumetric modulated arc therapy | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Teknik Bilimler Meslek Yüksekokulu, Elektronik ve Otomasyon Bölümü | en_US |
dc.contributor.institutionauthor | Çınar, Yunus | |
dc.identifier.doi | 10.1259/bjr.20190317 | |
dc.identifier.volume | 92 | en_US |
dc.identifier.issue | 1102 | en_US |
dc.ri.edit | oa | en_US |
dc.relation.journal | British Journal of Radiology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |