dc.contributor.author | Aktaş-Yokuş, Özlem | |
dc.contributor.author | Yüksek, Haydar | |
dc.contributor.author | Gürsoy-Kol, Özlem | |
dc.contributor.author | Karaoğlu, Şengül Alpay | |
dc.date.accessioned | 2020-12-19T19:41:36Z | |
dc.date.available | 2020-12-19T19:41:36Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Aktaş Yokuş, Ö., Yüksek, H., Gürsoy Kol, Ö. & Karaoğlu, Ş.A. (2018). In Vitro Antioxidant and Antimicrobial Properties of Some New 4,5-Dihydro-1H-1,2,4-triazole-5-ones. Indian Journal of Heterocyclic Chemistry, 28(3), 389-396. | en_US |
dc.identifier.issn | 0971-1627 | |
dc.identifier.uri | https://hdl.handle.net/11436/1800 | |
dc.description | Gursoy-Kol, Ozlem/0000-0003-2637-9023; Alpay Karaoglu, Sengul/0000-0003-1047-8350 | en_US |
dc.description | WOS: 000452028200012 | en_US |
dc.description.abstract | In this study, 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (3a-3h) reacted with 3-benzenesulfonyloxy-4-methoxybenzaldehyde (1a-1h) to afford eight new 3-alkyl(aryl)-4-(3-benzenesulfonyloxy-4-methoxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (4a-4h). Then, the acetylation reactions of compounds 4a-e and 4g were investigated and compounds 5 were obtained, respectively. the structures of fourteen new compounds were characterized by elemental analysis, IR H-1 nuclear magnetic resonance (NMR), C-13 NMR, mass spectrometry, and ultraviolet spectral data. the synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. Compounds 4d, 4e, and 5g showed the best activity for iron binding. in addition, the compounds 4a-4h were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents. Furthermore, these 14 new compounds and 14 recently reported 3-alkyl(ary1)-4-(4-benzenesulfonyloxybenzylidenarnino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (6a, 6b, 6d, 6e, and 6g-6i) and 1-acetyl-3-alkyl(aryl)-4-(4-benzenesulfonyloxybenzylide 4,5-dihydro-1H-1,2,4-triazol-5-ones (7a, 7b, 7d, 7e and 7g-7i) were screened for their antimicrobial activities. [GRAPHICS] . | en_US |
dc.description.sponsorship | Scientific Research Projects Coordination Unit of Kafkas UniversityKafkas University [2011-FEF-32] | en_US |
dc.description.sponsorship | Financial support provided by the Scientific Research Projects Coordination Unit of Kafkas University (Project Number: 2011-FEF-32) is gratefully acknowledged. the authors also thank Dr. Zafer Ocak for the determination of pK<INF>a</INF> values and Dr. Mustafa Calapoglu for antioxidant activities. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Connect Journals | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Synthesis | en_US |
dc.subject | Heterocycles | en_US |
dc.subject | Schiff bases, | en_US |
dc.subject | 1,2,4-Triazoles | en_US |
dc.subject | Biological activity | en_US |
dc.subject | Acidity | en_US |
dc.title | In vitro antioxidant and antimicrobial properties of some new 4,5-dihydro-1H-1,2,4-triazole-5-ones | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Fen - Edebiyat Fakültesi, Biyoloji Bölümü | en_US |
dc.contributor.institutionauthor | Karaoğlu, Şengül Alpay | |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 389 | en_US |
dc.identifier.endpage | 396 | en_US |
dc.relation.journal | Indian Journal of Heterocyclic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |