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dc.contributor.authorOzturk, Cengiz
dc.contributor.authorOzdemir, Nuriye Guzin
dc.contributor.authorKanat, Ayhan
dc.contributor.authorAydin, Mehmet Dumlu
dc.contributor.authorFindik, Huseyin
dc.contributor.authorAydin, Nazan
dc.contributor.authorCalik, Muhammet
dc.descriptionAYDIN, Nazan/0000-0003-3232-7713en_US
dc.descriptionWOS: 000434669900006en_US
dc.descriptionPubMed: 29241271en_US
dc.description.abstractBackground and Study Aim Basic neurophysiologic principles of the light reflex are well known. However, the effects of degenerated axon densities of oculomotor nerves (OMNs) secondary to posterior communicating artery (PComA) vasospasm following subarachnoid hemorrhage (SAH) have not been investigated. Our aim was to study this subject. Methods This study was conducted on 19 rabbits. There was a control group of five animals, a sham group of five animals in which saline was injected into the cisterna magna and a study group of nine animals in which homologous blood was injected into the cisterna magna. Pupillary diameters were measured for 1week, then the animals were decapitated. the normal and degenerated axon densities of the OMNs were examined by stereological methods. Vasospasm indexes (VSIs) of posterior communicating arteries (PComAs) supplying OMNs were estimated and analyzed statistically. Results the pupillary diameter was 5.439368 mu m, and the mean axon density of the OMNs was 0.924 +/- 324/mm (3) in the control group. the pupillary diameter and degenerated axon density of the OMNs in animals of the sham group were 6.980 +/- 0.370 mu m and 36 +/- 8/mm (3) , respectively. the pupillary diameter was 9.942 +/- 653 mu m, and degenerated axon density of the OMNs was 265 +/- 57/mm (3) in animals with SAH. the mean VSI values of PComAs were 0.927 +/- 0.224 in the control group, 1.542 +/- 0.257 in the sham group, and 2.321 +/- 0.324 in the SAH group. Conclusion We found a linear relationship between the axon density of the OMNs and pupillary diameters. High degenerated neuron density in the OMNs may be responsible for an unresponsive pupillary that has not been mentioned in the literature.en_US
dc.publisherThieme Medical Publ Incen_US
dc.subjectoculomotor nerveen_US
dc.subjectpupillary diameteren_US
dc.subjectsubarachnoid hemorrhageen_US
dc.titleHow Reliable Is Pupillary Evaluation Following Subarachnoid Hemorrhage? Effect of Oculomotor Nerve Degeneration Secondary to Posterior Communicating Artery Vasospasm: First Experimental Studyen_US
dc.relation.journalJournal of Neurological Surgery Part A-Central European Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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