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The protective effect of thiamine pryophosphate against sugar-induced retinal neovascularisation in rats

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Erişim

info:eu-repo/semantics/openAccess

Tarih

2018

Yazar

Çinici, Emine
Mammadov, Renad
Fındık, Hüseyin
Süleyman, Bahadır
Çetin, Nihal
Çalık, İlknur
Balta, Hilal
Taş, İsmail Hakkı
Şener, Ebru
Altuner, Durdu

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Künye

Cinici, E., Mammadov, R., Findik, H., Suleyman, B., Cetin, N., Calik, I., Balta, H., Hakki Tas, I., Sener, E., & Altuner, D. (2018). The Protective Effect of Thiamine Pryophosphate Against Sugar-Induced Retinal Neovascularisation in Rats. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 88(3-4), 137–143. https://doi.org/10.1024/0300-9831/a000248

Özet

The aim of this study was to investigate the effect of thiamine pyrophosphate (TPP), administered via sugar water, on retinal neovascularisation in rats. Animals were assigned to three groups, namely the TPP sugar-water group (TPSWG, n = 12), the control group (CG, n = 12) and the healthy group (HG, n = 12). the TPSWG was injected intraperitoneally with TPP once a day for 6 months. CG and HG rats were given distilled water in the same way. TPSWG and CG rats were left free to access an additional 0.292 mmol/ml of sugar water for 6 months. the fasting blood glucose (FBG) levels of the animals were measured monthly. After 6 months, biochemical, gene expression and histopathologic analyses were carried out in the retinal tissues removed from the animals after they were killed. the measured FBG levels were 6.96 +/- 0.09 mmol/ml (p < 0.0001 vs. HG), 6.95 +/- 0.06 mmol/ml (p < 0.0001 vs. HG) and 3.94 +/- 0.10 mmol/ml in the CG, TPSWG and HG groups, respectively. the malondialdehyde (MDA) levels were found to be 2.82 +/- 0.23 (p < 0.0001 vs. HG), 1.40 +/- 0.32 (p < 0.0001 vs. HG) and 1.66 +/- 0.17 in the CG, TPSWG and HG, respectively. Interleukin 1 beta (IL-1 beta) gene expression was increased (3.78 +/- 0.29, p < 0.0001) and total glutathione (tGSH) was decreased (1.32 +/- 0.25, p < 0.0001) in the retinal tissue of CG compared with TPSWG (1.92 +/- 0.29 and 3.18 +/- 0.46, respectively). Increased vascularisation and oedema were observed in the retinal tissue of CG, while the retinal tissues of TPSWG and HG rats had a normal histopathological appearance. A carbohydrate-rich diet may lead to pathological changes in the retina even in nondiabetics, but this may be overcome by TPP administration.

Kaynak

International Journal For Vitamin and Nutrition Research

Cilt

88

Sayı

03.Apr

Bağlantı

https://doi.org/10.1024/0300-9831/a000248
https://hdl.handle.net/11436/1822

Koleksiyonlar

  • PubMed İndeksli Yayınlar Koleksiyonu [2443]
  • Scopus İndeksli Yayınlar Koleksiyonu [6000]
  • TF, Cerrahi Tıp Bilimleri Bölümü Koleksiyonu [1221]
  • WoS İndeksli Yayınlar Koleksiyonu [5260]



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