Synthesis and antioxidant, antiurease and anti-xanthine oxidase activities of some new benzimidazoles bearing triazole, oxadiazole, thiadiazole and imin function

Abstract

In this study, a series of new 2-(4-nitrobenzyl)-1H-benzimidazole derivatives bearing thiosemicarbazide, triazole, oxadiazole and thiadiazole moieties at the 1st position of benzimidazole ring have been synthesized and screened for their antioxidant, antiurease and anti-xanthine oxidase activities. Antioxidant activities of the synthesized compounds have been determined with CUPric Reducing Antioxidant Capacity (CUPRAC), ABTS (2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)/persulfate and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays. Most of the compounds show significant antioxidant activity. Also, among the tested compounds, 9c displays the best inhibitory effect against XO with an IC50 value of 12.30 +/- 0.33 mu g/mL and compound 7ashows the best inhibitory effect against urease with an IC50 value of 13.04 +/- 0.89 mu g/mL.