dc.contributor.author | Kanat, Ayhan | |
dc.contributor.author | Aydın, M. Dumlu | |
dc.contributor.author | Bayram, Ednan | |
dc.contributor.author | Kazdal, Hızır | |
dc.contributor.author | Aydın, Nazan | |
dc.contributor.author | Ömeroğlu, Muhammet | |
dc.contributor.author | Altınkaynak, Konca | |
dc.contributor.author | Kabalar, M. Eşref | |
dc.contributor.author | Yolaş, Coşkun | |
dc.contributor.author | Öztürk, Cengiz | |
dc.contributor.author | Kepoğlu, Ümit | |
dc.contributor.author | Çalık, Muhammet | |
dc.date.accessioned | 2020-12-19T19:48:27Z | |
dc.date.available | 2020-12-19T19:48:27Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Kanat, A., Aydin, M. D., Bayram, E., Kazdal, H., Aydin, N., Omeroglu, M., Altinkaynak, K., Kabalar, M. E., Yolas, C., Ozturk, C., Kepoglu, U., & Calik, M. (2017). A New Determinant of Poor Outcome After Spontaneous Subarachnoid Hemorrhage: Blood pH and the Disruption of Glossopharyngeal Nerve-Carotid Body Network: First Experimental Study. World neurosurgery, 104, 330–338. https://doi.org/10.1016/j.wneu.2017.04.105 | en_US |
dc.identifier.issn | 1878-8750 | |
dc.identifier.issn | 1878-8769 | |
dc.identifier.uri | https://doi.org/10.1016/j.wneu.2017.04.105 | |
dc.identifier.uri | https://hdl.handle.net/11436/2082 | |
dc.description | AYDIN, Nazan/0000-0003-3232-7713; Kanat, Ayhan/0000-0002-8189-2877 | en_US |
dc.description | WOS: 000407713100045 | en_US |
dc.description | PubMed: 28456740 | en_US |
dc.description.abstract | OBJECTIVE: the chemoreceptor network, consisting of the glossopharyngeal nerve and carotid body (GPN-CB), is essential for the regulation of blood pH. Its ischemic insults after subarachnoid hemorrhage (SAH), which may contribute to acidosis, have not been investigated. METHODS: Twenty-three hybrid rabbits were used. They were divided into 3 groups: 5 as a control group, 5 as a sham group, and the remaining 13 as the study group. Injections included 1 cm3 serum saline and 1 cm3 autolog arterial blood into the cisterna magna in the sham and study group, respectively. Blood pH values of all animals were recorded. After 2 weeks, animals were euthanized. the number of normal and degenerated neurons of the carotid bodies (CBs) was counted by stereologic methods and analyzed statistically. RESULTS: Two of 13 rabbits died within the second week. the mean blood pH values were measured as 7.35 +/- 0.07 in the control group (n = 5), 7.33 +/- 0.06 in the sham group (n = 5), 7.29 +/- 0.05 in rabbits with slight acidosis (n = 6), and 7.23 +/- 0.02 in rabbits with prominent acidosis (n = 7). in the control group, the average normal neuronal density of the CBs was 6432 +/- 790/mm(3) and the degenerated neuron density was 11 +/- 3/mm(3), whereas the degenerated neuronal density in CBs was 35 +/- 8/mm(3) in the sham group and 1034 +/- 112/mm(3) in the slight acidosisedeveloped group (n = 6; P < 0.05). Conversely, degenerated neuron density of CBs was 2134 +/- 251/mm(3) in the prominent acidosise developed animals (n = 7; P < 0.005). Interestingly, in the rabbits who died, the degenerated neuron density of the CB was 3160 +/- 840/mm(3). CONCLUSION: An inverse relationship between neurodegeneration in the CB and pH values secondary to the disruption of the GPN-CB network after SAH was found, which may contribute to developing acidosis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science Inc | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Acidosis | en_US |
dc.subject | Carotid body | en_US |
dc.subject | Glossopharyngeal nerve | en_US |
dc.subject | pH | en_US |
dc.subject | Subarachnoid hemorrhage | en_US |
dc.title | A new determinant of poor outcome after spontaneous subarachnoid hemorrhage: Blood pH and the disruption of glossopharyngeal nerve-carotid body network: First experimental study | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Kanat, Ayhan | |
dc.contributor.institutionauthor | Kazdal, Hızır | |
dc.identifier.doi | 10.1016/j.wneu.2017.04.105 | |
dc.identifier.volume | 104 | en_US |
dc.identifier.startpage | 330 | en_US |
dc.identifier.endpage | 338 | en_US |
dc.relation.journal | World Neurosurgery | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |