dc.contributor.author | Arabacı, Taner | |
dc.contributor.author | Köse, Oğuz | |
dc.contributor.author | Albayrak, Mevlüt | |
dc.contributor.author | Çiçek, Yasin | |
dc.contributor.author | Kızıldağ, Alper | |
dc.date.accessioned | 2020-12-19T19:48:28Z | |
dc.date.available | 2020-12-19T19:48:28Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Arabacı, T., Kose, O., Albayrak, M., Cicek, Y., & Kizildag, A. (2017). Advantages of Autologous Platelet-Rich Fibrin Membrane on Gingival Crevicular Fluid Growth Factor Levels and Periodontal Healing: A Randomized Split-Mouth Clinical Study. Journal of periodontology, 88(8), 771–777. https://doi.org/10.1902/jop.2017.160485 | en_US |
dc.identifier.issn | 0022-3492 | |
dc.identifier.issn | 1943-3670 | |
dc.identifier.uri | https://doi.org/10.1902/jop.2017.160485 | |
dc.identifier.uri | https://hdl.handle.net/11436/2085 | |
dc.description | WOS: 000406497500010 | en_US |
dc.description | PubMed: 28452623 | en_US |
dc.description.abstract | Background: This study evaluates contributions of platelet-rich fibrin (PRF) combined with conventional flap surgery on growth factor levels in gingival crevicular fluid (GCF) and periodontal healing. Methods: Twenty-six patients (52 sites) with chronic periodontitis were treated either with autologous PRF with open flap debridement (OFD+PRF) or OFD alone. Growth factor levels in GCF at baseline and 2, 4, and 6 weeks after surgery were analyzed, and clinical parameters such as probing depth (PD), relative clinical attachment level (rCAL), and gingival margin level (GML) at baseline and 9 months after surgery were measured. Results: Mean PD reduction and rCAL gain were significantly greater in OFD+ PRF sites than in OFD sites. Mean GML change was -0.38 + 0.10 mm in OFD sites and 0.11 + 0.08 mm in the test group; difference between the two groups was statistically significant (P < 0.05). Both groups demonstrated increased expression levels of fibroblast growth factor-2, transforming growth factor-b1, and platelet-derived growth factor-BB at 2 weeks compared with baseline, followed by reductions at 4 and 6 weeks. the OFD+ PRF group showed significantly higher growth factor levels compared with the OFD group at 2 and 4 weeks. Conclusion: PRF membrane combined with OFD provides significantly higher GCF concentrations of angiogenic biomarkers for approximate to 2 to 4 weeks and better periodontal healing in terms of conventional flap sites. | en_US |
dc.description.sponsorship | Scientific Research Fund of Ataturk UniversityAtaturk University [AtaUni BAP-2011/300] | en_US |
dc.description.sponsorship | This study was supported by the Scientific Research Fund of Ataturk University (AtaUni BAP-2011/300) to Dr. Arabaci. the authors report no conflicts of interest related to this study. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Intercellular signaling peptides and proteins | en_US |
dc.subject | Periodontitis | en_US |
dc.subject | Wound healing | en_US |
dc.title | Advantages of autologous platelet-rich fibrin membrane on gingival crevicular fluid growth factor levels and periodontal healing: A randomized split-mouth clinical study | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü | en_US |
dc.contributor.institutionauthor | Köse, Oğuz | |
dc.identifier.doi | 10.1902/jop.2017.160485 | |
dc.identifier.volume | 88 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.startpage | 771 | en_US |
dc.identifier.endpage | 777 | en_US |
dc.relation.journal | Journal of Periodontology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |