Elevated serum levels of signal peptide-CUB-EGF domain-containing protein1 (SCUBE1) are associated with poor pulmonary thromboembolism (PTE) prognosis.

Abstract

Introduction: the prognostic role of SCUBE1 serum levels in PTE has best of our knowledge, not been previously investigated. Materials and methods: the study included 49 patients diagnosed as having acute PTE. This single-centre prospective study was conducted between Jan 2015 and 2016. the diagnosis of PTE was reached through spiral angio computed thorax tomography. Serum SCUBE1 was measured on admission. Troponin-T, cardiac enzymes, echocardiography and simplified pulmonary embolism severity index (sPESI) of all the patients were recorded. Findings: the mean age at diagnosis was 69.4 +/- 13.4 y who are 20 male and 29 female patients. the mean serum SCUBE1 level in our study was 1.79 +/- 0.24 ng/ml. the serum SCUBE1 level was significantly higher in the cases with high-risk sPESI than those with low-risk sPESI (18.00 +/- 0.26 ng/ml and 17.75 +/- 0.17 ng/ml (p=0.001), respectively). It was also shown that there was a significant correlation between the SCUBE1 and serum albumin levels (r=-0.501) and Red Cell Distribution Width (RDW) (r=0.301) and urea (r=0.296). None of the patients passed away during hospitalization and one-month follow-up. Conclusion: SCUBE1 can be used for predicting in patients with PTE. However, further studies are essential, and in particular should include high-risk (massive) pulmonary embolism patients.