Oxidative stress and antioxidant status in patients with bell's palsy

Abstract

Background: Bell's palsy (BP) is the most common acute mononeuropathy of unilateral facial paralysis. Immune, infective and ischaemic mechanisms are potential contributors to the development of BP, but the precise cause remains unclear. Recently, oxidative stress has been proposed as a risk factor of various idiopathic diseases. the aim of this study was to investigate the possible role of oxidative stress in patients with BP. Methods: Thirty-two patients with BP and 30 healthy controls were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were measured by the Erel method. Results: Serum TOS activities and OSI values were significantly higher in patients with BP compared with the control group (P < 0.003 for all comparisons), whereas there was no significant difference between the groups in terms of TAS levels (P > 0.05). Conclusions: the data suggest that oxidative stress is increased in BP. These results of high oxidative stress in patients with BP may be helpful to clarify the etiopathogenesis of BP and contribute to improvement in the management or prevention of the disease.