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dc.contributor.authorOnen, Mehmet Reşid
dc.contributor.authorYılmaz, İlhan
dc.contributor.authorRamazanoğlu, Leyla
dc.contributor.authorTanrıverdi, Osman
dc.contributor.authorAydın, Mehmet Dumlu
dc.contributor.authorKanat, Ayhan
dc.contributor.authorYolaş, Coşkun
dc.contributor.authorSipal, Sare
dc.date.accessioned2020-12-19T19:50:31Z
dc.date.available2020-12-19T19:50:31Z
dc.date.issued2016
dc.identifier.citationOnen, M. R., Yilmaz, I., Ramazanoglu, L., Tanrıverdi, O., Aydin, M. D., Kanat, A., Yolas, C., & Sipal, S. (2016). Rational Roots of Sympathetic Overactivity by Neurogenic Pulmonary Edema Modeling Arising from Sympathyco-Vagal Imbalance in Subarachnoid Hemorrhage: An Experimental Study. World neurosurgery, 92, 463–470. https://doi.org/10.1016/j.wneu.2016.04.067en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2016.04.067
dc.identifier.urihttps://hdl.handle.net/11436/2439
dc.descriptionKanat, Ayhan/0000-0002-8189-2877en_US
dc.descriptionWOS: 000384160300063en_US
dc.descriptionPubMed: 27132179en_US
dc.description.abstractBACKGROUND: Autonomous innervations of the lungs are maintained by cervical sympathetic and vagal nerves. Sympathetic overactivity-induced neurogenic pulmonary edema (NPE) is known as a serious complication of subarachnoid hemorrhage, but the rational neuronal mechanism of that overactivity has not yet been clarified fully. the aim of this study was to examine whether there is a relationship between vagal nerve ischemia related sympathetic overactivity and neurogenic pulmonary edema in subarachnoid hemorrhage. METHODS: This study was conducted on 27 rabbits. A control group was formed of 5 animals, a sham group of 7 to which saline was administered, and a study group of 15 animals that were injected with homologous arterial blood into the cisterna magna. Electrocardiography and respiratory rhythm parameters were monitored for 3 weeks and the animals were then decapitated. Statistical analysis was made of the numbers of degenerated axons in the pulmonary branches of the vagal nerves, the neuron density of stellate ganglions and the vasospasm index of the pulmonary arteries. RESULTS: in the control group, the normal respiration rate was 34 +/- 6 bpm, total axon number was 1600 +/- 270/mm(2), degenerated axon number was 10 +/- 3/mm(2), and vasospasm index was 1.34 +/- 0.25. the sham group values were 30 +/- 3 bpm, 163 +/- 47/mm(2), and 1.95 +/- 0.45 and the study group values were 45 +/- 8 bpm, 530 +/- 92/mm(2), and 2.76 +/- 0.83. the mean stellate ganglion neuron density was evaluated as 8.112 +/- 1.230/mm(3) in all animals, as 7.420 +/- 4.10/mm(3) in animals with slight NPE, and as 12.512 +/- 1.236/mm(3) in animals that developed severe NPE. CONCLUSION: High neuron density of stellate ganglion may have important roots in sympathetic overactivity-related NPE development in subarachnoid hemorrhage.en_US
dc.language.isoengen_US
dc.publisherElsevier Science Incen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRespirationen_US
dc.subjectSubarachnoid hemorrhageen_US
dc.subjectVagal ischemiaen_US
dc.titleRational roots of sympathetic overactivity by neurogenic pulmonary edema modeling arising from sympathyco-vagal imbalance in subarachnoid hemorrhage: An experimental studyen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorKanat, Ayhan
dc.identifier.doi10.1016/j.wneu.2016.04.067
dc.identifier.volume92en_US
dc.identifier.startpage463en_US
dc.identifier.endpage470en_US
dc.relation.journalWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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