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dc.contributor.authorSahutoğlu, Tuncay
dc.contributor.authorAtay, Kadri
dc.contributor.authorÇalışkan, Yaşar
dc.contributor.authorKara, Ekrem
dc.contributor.authorYazıcı, Halil
dc.contributor.authorTürkmen, Aydın
dc.date.accessioned2020-12-19T19:50:44Z
dc.date.available2020-12-19T19:50:44Z
dc.date.issued2016
dc.identifier.citationSahutoglu, T., Atay, K., Caliskan, Y., Kara, E., Yazici, H., & Turkmen, A. (2016). Comparative Analysis of Outcomes of Kidney Transplantation in Patients With AA Amyloidosis and Chronic Glomerulonephritis. Transplantation proceedings, 48(6), 2011–2016. https://doi.org/10.1016/j.transproceed.2016.04.015en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2016.04.015
dc.identifier.urihttps://hdl.handle.net/11436/2463
dc.descriptionSahutoglu, Tuncay/0000-0003-2015-4421;en_US
dc.descriptionWOS: 000383528700025en_US
dc.descriptionPubMed: 27569937en_US
dc.description.abstractBackground. Amyloid A (AA) amyloidosis is a multisystemic, progressive, and severe disease. Renal involvement is a prominent feature of the disease, and the outcome of patients on dialysis is poor. We aimed to analyze the outcomes of kidney transplantation in patients with AA amyloidosis in comparison with chronic glomerulonephritis (CGN). Methods. Charts of patients who underwent kidney transplantation between 1988 and 2012 were reviewed; 41 patients with AA amyloidosis were identified, and 41 age-and sex-matched control patients with chronic CGN were included. Baseline characteristics, immunosuppressive regimens, and transplantation-related outcomes were retrieved using a standardized form. Results. the mean follow-up period was 70.9 +/- 44.9 months. the 10-year patient survival was found to be significantly worse in the AA amyloidosis group (62.5%) compared to CGN group (100%) (P =.008). During the follow-up period, three of the 41 patients (9.7%) died of sepsis and one patient died of cardiac complications in the amyloidosis group, whereas there was no patients were lost in the CGN group. the first-year, fifth year, and tenth-year mean graft survival rates, acute and chronic rejections, and mean creatinine levels at last visits were not significantly different between the groups. Proteinuria >1 g/d, cytomegalovirus and tuberculosis infections, and rhabdomyolysis were recorded at a significantly higher rate in patients with amyloidosis. Conclusion. As compared to patients with CGN, patients with AA amyloidosis had a lower patient survival; equal graft survival and rejection rates; and higher risks of developing proteinuria, cytomegalovirus and tuberculosis infections, and rhabdomyolysis.en_US
dc.language.isoengen_US
dc.publisherElsevier Science Incen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFamilial mediterranean feveren_US
dc.subjectSingle-center experienceen_US
dc.subjectStage renal-diseaseen_US
dc.subjectSystemic amyloidosisen_US
dc.titleComparative analysis of outcomes of kidney transplantation in patients with AA amyloidosis and chronic glomerulonephritisen_US
dc.typearticleen_US
dc.contributor.departmentRTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.contributor.institutionauthorKara, Ekrem
dc.identifier.doi10.1016/j.transproceed.2016.04.015
dc.identifier.volume48en_US
dc.identifier.issue6en_US
dc.identifier.startpage2011en_US
dc.identifier.endpage2016en_US
dc.relation.journalTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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