Difficulties in the treatment of an Infant with Hemophilia B

Abstract

Hemophilia B is a X-linked recessive bleeding disorder which occurs as a result of Factor IX (FIX) deficiency (1, 2). In some patients with hemophilia, antibody (inhibitor) and allergic reaction may develop against FIX protein which is administered for treatment (3). While antibody develops against the factor administered in approximately 15-25% of the patients with severe hemophilia A, this rate is much lower in patients with hemophilia B (3%). Life-threatening allergic reactions may develop in 50% of the patients who have inhibitor (4).