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A comparative investigation of the analgesic effects of metamizole and paracetamol in rats

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Erişim

info:eu-repo/semantics/closedAccess

Tarih

2015

Yazar

İnce, İlker
Aksoy, Mehmet
Ahıskalıoğlu, Ali
Çömez, Mehmet
Dostbil, Ayşenur
Çelik, Mine
Yılmaz, İsmail
Mammadov, Renad
Doğan, Hasan
Özgermen, Boztok
Altuner, Durdu

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Künye

Ince, I., Aksoy, M., Ahiskalioglu, A., Comez, M., Dostbil, A., Celik, M., Yilmaz, I., Mammadov, R., Dogan, H., Boztok Ozgermen, B., & Altuner, D. (2015). A Comparative Investigation of the Analgesic Effects of Metamizole and Paracetamol in Rats. Journal of investigative surgery : the official journal of the Academy of Surgical Research, 28(3), 173–180. https://doi.org/10.3109/08941939.2014.998798

Özet

Background: This study investigated the effects of metamizole and paracetamol on pain and oxidative stress induced by scalpel incision and carrageenan in rats. Materials and methods: Total of 144 rats were divided into groups of 12 animals. Six groups each were used for scalpel incision and carrageenan tests. Pain was inflicted by applying a scalpel incision or carrageenan. Pain-created groups by scalpel incision received metamizole (SIM) or paracetamol (SIP) at doses of 250 or 500 mg/kg. Pain-created groups by carrageenan received metamizole (CAM) or paracetamol (CAP) at doses of 250 or 500 mg/kg. Analgesic activity was determined by Basile Algesimeter. the COX-2 and MPO gene expressions were determined, and malondialdehyde and tGSH were measured in rat paws. Results: in the scalpel incision test, pain was reduced in groups of SIM-250 and SIM-500 in the first hour by 65.2% and 91.3%, respectively, and in the third hour by 51.9% and 77.8%, respectively, compared with the SIC group. in SIP-250 and SIP-500 groups, pain was reduced in the first hour by 43% and 74%, respectively, and by 33.4% and 59.3%, respectively, in the third hour compared with the SIC group. in the carrageenan test, in groups CAM-250 and CAM-500, pain was reduced in the first hour by 72.3% and 86.1%, respectively, and by 65.8% and 71.4%, respectively, in the third hour compared with the CCG group. in groups CAP-250 and CAP-500, pain was reduced in the first hour by 52.8% and 69.4%, respectively, and by 28.6% and 25.8%, respectively, in the third hour compared with the CCG group. Metamizole inhibited COX-2 gene expression at a dose of 500 mg/kg in the carrageenan test. At doses of 250 and 500 mg/kg, metamizole reduced COX-2 and MPO gene expressions and oxidative stress induced by scalpel incision or carrageenan. But both doses of paracetamol were unable to suppress that parameters. Conclusions: Our results show that metamizole is more effective than paracetamol for treating surgical trauma-related pain, inflammation, and oxidative stress and hence may be a preferential drug to paracetamol.

Kaynak

Journal of Investigative Surgery

Cilt

28

Sayı

3

Bağlantı

https://doi.org/10.3109/08941939.2014.998798
https://hdl.handle.net/11436/2812

Koleksiyonlar

  • PubMed İndeksli Yayınlar Koleksiyonu [2443]
  • Scopus İndeksli Yayınlar Koleksiyonu [5998]
  • TF, Dahili Tıp Bilimleri Bölümü Koleksiyonu [1571]
  • WoS İndeksli Yayınlar Koleksiyonu [5260]



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