dc.contributor.author | Parlak, Emine | |
dc.contributor.author | Ertürk, Ayşe | |
dc.contributor.author | Çağ, Yasemin | |
dc.contributor.author | Şebin, Engin | |
dc.contributor.author | Gümüşdere, Musa | |
dc.date.accessioned | 2020-12-19T19:58:11Z | |
dc.date.available | 2020-12-19T19:58:11Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Parlak, E., Ertürk, A., Çağ, Y., Sebin, E., & Gümüşdere, M. (2015). The effect of inflammatory cytokines and the level of vitamin D on prognosis in Crimean-Congo hemorrhagic fever. International journal of clinical and experimental medicine, 8(10), 18302–18310. | en_US |
dc.identifier.issn | 1940-5901 | |
dc.identifier.uri | https://hdl.handle.net/11436/2932 | |
dc.description | ERTURK, AYSE/0000-0001-6413-9165 | en_US |
dc.description | WOS: 000367669800140 | en_US |
dc.description | PubMed: 26770432 | en_US |
dc.description.abstract | Crimean-Congo haemorrhagic fever (CCHF) is a tick-borne viral disease. Its pathogenesis basically involves endothelial damage. the aim of this study was to determine serum IL2, IL6, IL 10 and 25 OH Vitamin D levels in patients with CCHF and also to reveal their role in the clinical course and prognosis of the disease. Diagnosis of CCHF was confirmed using the positive polymerase chain reaction (PCR) test and/or positive IgM antibody by enzyme-linked immunosorbent assay (ELISA). Serum IL-2, IL-6, IL-10 and total 25 OH Vitamin D levels were also measured using ELISA. Eighty CCHF patients and 110 healthy controls were enrolled. IL2, IL6 and IL10 levels were significantly higher in the patient group. IL 6 and IL 10 levels were significantly higher in the fatal group. There was a positive correlation between Vitamin D and AST (r = 0.402; P < 0.001), and another positive correlation between IL-6 and CK (r = 0.714; P < 0.001). High IL6 and L10 levels are a significant indicator of fatality. Cytokines are only one of the factors responsible for mortality. We conclude that the pathogenesis of the disease can be better understood by elucidating the complicated cytokine network. | en_US |
dc.description.sponsorship | Ataturk University Scientific Research Projects CommissionAtaturk University [2012-24] | en_US |
dc.description.sponsorship | We thank Dr. Yasemin Cayir for advice on statistical analysis; Dr. Hulya Aksoy for assistance with development of biochemical outcome measures. This study was supported by the Ataturk University Scientific Research Projects Commission (Project No. 2012-24). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | E-Century Publishing Corp | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Crimean-Congo hemorrhagic fever | en_US |
dc.subject | Cytokine | en_US |
dc.subject | Fatality | en_US |
dc.subject | Vitamin D Introduction | en_US |
dc.title | The effect of inflammatory cytokines and the level of vitamin D on prognosis in Crimean-Congo hemorrhagic fever | en_US |
dc.type | article | en_US |
dc.contributor.department | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü | en_US |
dc.contributor.institutionauthor | Ertürk, Ayşe | |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.startpage | 18302 | en_US |
dc.identifier.endpage | 18310 | en_US |
dc.relation.journal | International Journal of Clinical and Experimental Medicine | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |